全文获取类型
收费全文 | 390篇 |
免费 | 26篇 |
专业分类
耳鼻咽喉 | 1篇 |
妇产科学 | 3篇 |
基础医学 | 47篇 |
临床医学 | 27篇 |
内科学 | 38篇 |
皮肤病学 | 9篇 |
神经病学 | 195篇 |
特种医学 | 21篇 |
外科学 | 28篇 |
预防医学 | 2篇 |
眼科学 | 32篇 |
药学 | 5篇 |
肿瘤学 | 8篇 |
出版年
2023年 | 2篇 |
2022年 | 8篇 |
2021年 | 7篇 |
2020年 | 3篇 |
2018年 | 7篇 |
2017年 | 6篇 |
2016年 | 13篇 |
2015年 | 12篇 |
2014年 | 11篇 |
2013年 | 14篇 |
2012年 | 28篇 |
2011年 | 26篇 |
2010年 | 21篇 |
2009年 | 16篇 |
2008年 | 21篇 |
2007年 | 44篇 |
2006年 | 27篇 |
2005年 | 28篇 |
2004年 | 28篇 |
2003年 | 17篇 |
2002年 | 14篇 |
2001年 | 1篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 7篇 |
1997年 | 5篇 |
1996年 | 5篇 |
1995年 | 5篇 |
1994年 | 5篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1991年 | 5篇 |
1989年 | 1篇 |
1988年 | 3篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1981年 | 1篇 |
1977年 | 1篇 |
1975年 | 3篇 |
1974年 | 1篇 |
1973年 | 2篇 |
1971年 | 2篇 |
1957年 | 3篇 |
排序方式: 共有416条查询结果,搜索用时 15 毫秒
91.
Ken Watanabe Hidenao Ideta Junji Nakatake Kouichi Shinagawa Seiji Demizu Chiaki Takenaka 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1995,233(2):71-73
Background: Inflammation caused by transconjunctival cryotherapy for prophylactic retinal detachment surgery was measured in various conditions. Methods: Thirty-four eyes of 28 patients with peripheral retinal lesions predisposing to retinal detachment were studied by laser flare cell meter before and after treatment. Results: The mean flare value for 34 eyes was 4.06 ± 1.45 photon counts/ms before surgery and 5.72 ± 2.52 pc/ms after surgery (p < 0.05). Flare value was elevated at 1, 2, and 3 weeks after treatment, peaking at 2 weeks (p < 0.05), and normal again at 4 weeks. There were no significant differences in flare increase between eyes with and without retinal breaks, eyes with and without limited retinal detachment, eyes with myopia more and less than – 8.0 D, and eyes with a treatment area limited to one quadrant and extending over more than one quadrant. Conclusion: Transconjunctival cryosurgery caused mild inflammation in the anterior chamber of the eye for 3 weeks. The inflammation was not affected by the presence of retinal break or limited retinal detachment, the degree of myopia, or the extent of the treatment area. 相似文献
92.
Epidemiologic characteristics of rhegmatogenous retinal detachment in Kumamoto,Japan 总被引:2,自引:0,他引:2
H. Ideta J. Yonemoto S. Tanaka A. Hirose C. Oka K. Sasaki 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1995,233(12):772-776
Background: The epidemiology of rhegmatogenous retinal detachment in Asians is not well known. We studied the epidemiologic characteristics of rhegmatogenous retinal detachment in Kumamoto, Japan. Methods: The study was based on a retrospective chart review of hospital patients who were treated for primary rhegmatogenous retinal detachment in 1990. The data were collected from seven hospitals in the Kumamoto area. Results: From a population of 1 840000, 192 residents developed retinal detachment. The annual incidence was therefore 10.4 per 100000 population (9.6 for males, 11.2 for females). The incidences of three types of detachment — nontraumatic phakic, aphakic, and blunt trauma — were 9.8, 0.5, and 0.2 per 100000 population, respectively. In 109 of 180 patients (60.6%) with nontraumatic phakic detachment, retinal breaks were associated with lattice degeneration. In females, 14 of 106 nontraumatic phakic cases (13.2%) were secondary to macular holes. Conclusion: Compared with previously published studies from other countries, the incidence of detachments associated with lattice degeneration and macular hole was higher, while the incidences of aphakic detachment and detachment due to blunt trauma were lower in Japan. Racial factors and living habits may affect the development of retinal detachment. 相似文献
93.
Akihiro Ohsumi Hidenao Kayawake Yoshito Yamada Satona Tanaka Yojiro Yutaka Daisuke Nakajima Masatsugu Hamaji Toshi Menju Hiroshi Date 《Interactive Cardiovascular and Thoracic Surgery》2022,35(2)
Open in a separate window Lung parenchyma-sparing bronchial resection is uncommon, and the operative procedure depends on the cause and location of the stenosis. We present 6 cases and discuss the different surgical strategies for sleeve resection of the central airway without lung resection. Bronchoplasty for the main bronchus and truncus intermedius was performed with a posterolateral approach. We resected the right main bronchus including the right lateral wall of the lower trachea and half of the carina obliquely and performed an anastomosis. The tumour in the left lobar bronchus was exposed and removed by transient division of the accompanying pulmonary artery. Although post-transplant stenosis and malacia can pose a challenge, bronchoplasty can be used as a definitive treatment in experienced centres. 相似文献
94.
G protein‐coupled receptor 26 immunoreactivity in intranuclear inclusions associated with polyglutamine and intranuclear inclusion body diseases 下载免费PDF全文
Fumiaki Mori Kunikazu Tanji Yasuo Miki Yasuko Toyoshima Mari Yoshida Akiyoshi Kakita Hitoshi Takahashi Jun Utsumi Hidenao Sasaki Koichi Wakabayashi 《Neuropathology》2016,36(1):50-55
G protein‐coupled receptor 26 (GPR26) is one of the G‐protein‐coupled receptors (GPCRs), which comprise the largest family of membrane proteins and mediate most of the physiological responses to hormones, neurotransmitters and environmental stimulants. Although GPCRs are considered to play an important role in the pathophysiology of neurodegenerative disorders, it is uncertain whether GPR26 is involved in the pathogenesis of polyglutamine and intranuclear inclusion body diseases. We immunohistochemically examined the brain tissues of patients with four polyglutamine diseases (Huntington's disease, dentatorubral‐pallidoluysian atrophy, and spinocerebellar ataxia types 1 and 3) and intranuclear inclusion body disease, and normal control subjects. In controls, anti‐GPR26 antibody immunolabeled the neuronal cytoplasm in a diffuse granular pattern. Neuronal nuclear inclusions in polyglutamine diseases were immunopositive for GPR26. In intranuclear inclusion body disease, GPR26‐positive nuclear inclusions were found in both neurons and glial cells. Marinesco bodies in aged control subjects were also positive for GPR26. Double immunofluorescence analysis revealed co‐localization of GPR26 with polyglutamine or ubiquitin in these nuclear inclusions. These findings suggest that GPR26 may have a common role in the formation or degradation of intranuclear inclusions in several neurodegenerative diseases. 相似文献
95.
Hidenao Sasaki Hideaki Kojima Ichiro Yabe Kunio Tashiro Takeshi Hamada Hirofumi Sawa Hiroaki Hiraga K. Nagashima 《Acta neuropathologica》1998,95(2):199-204
SCA6 is an autosomal dominant spinocerebellar ataxia (SCA) caused by a small CAG repeat expansion of the gene encoding an
α-1a-voltage-dependent Ca channel gene subunit on chromosome 19p13. A Japanese woman with SCA6, with a 7-year history of progressive
pure cerebellar ataxia, died of malignant lymphoma. Systematic neuropathological examination showed that neuronal degeneration
was confined to the cerebellar Purkinje cells and, to a lesser degree, the granular cells, without any involvement of other
central nervous system structures. Such pathological selectivity correlates with the localized expression of the responsible
gene, and coincides with the neurological manifestation. These findings might contribute to establishing the phenotype of
the SCA6 via comparison with other dominant ataxias.
Received: 7 July 1997 / Revised, accepted: 14 August 1997 相似文献
96.
97.
Sleep modulates cortical connectivity and excitability in humans: Direct evidence from neural activity induced by single‐pulse electrical stimulation 下载免费PDF全文
Kiyohide Usami Riki Matsumoto Katsuya Kobayashi Takefumi Hitomi Akihiro Shimotake Takayuki Kikuchi Masao Matsuhashi Takeharu Kunieda Nobuhiro Mikuni Susumu Miyamoto Hidenao Fukuyama Ryosuke Takahashi Akio Ikeda 《Human brain mapping》2015,36(11):4714-4729
Sleep‐induced changes in human brain connectivity/excitability and their physiologic basis remain unclear, especially in the frontal lobe. We investigated sleep‐induced connectivity and excitability changes in 11 patients who underwent chronic implantation of subdural electrodes for epilepsy surgery. Single‐pulse electrical stimuli were directly injected to a part of the cortices, and cortico‐cortical evoked potentials (CCEPs) and CCEP‐related high‐gamma activities (HGA: 100–200 Hz) were recorded from adjacent and remote cortices as proxies of effective connectivity and induced neuronal activity, respectively. HGA power during the initial CCEP component (N1) correlated with the N1 size itself across all states investigated. The degree of cortical connectivity and excitability changed during sleep depending on sleep stage, approximately showing dichotomy of awake vs. non‐rapid eye movement (REM) [NREM] sleep. On the other hand, REM sleep partly had properties of both awake and NREM sleep, placing itself in the intermediate state between them. Compared with the awake state, single‐pulse stimulation especially during NREM sleep induced increased connectivity (N1 size) and neuronal excitability (HGA increase at N1), which was immediately followed by intense inhibition (HGA decrease). The HGA decrease was temporally followed by the N2 peak (the second CCEP component), and then by HGA re‐increase during sleep across all lobes. This HGA rebound or re‐increase of neuronal synchrony was largest in the frontal lobe compared with the other lobes. These properties of sleep‐induced changes of the cortex may be related to unconsciousness during sleep and frequent nocturnal seizures in frontal lobe epilepsy. Hum Brain Mapp, 2015. © 2015 Wiley Periodicals, Inc . 相似文献
98.
The Uncinate Fasciculus as a Predictor of Conversion from Amnestic Mild Cognitive Impairment to Alzheimer Disease 下载免费PDF全文
99.
Masaaki Matsushima Ichiro Yabe Koji Oba Ken Sakushima Yasunori Mito Asako Takei Hideki Houzen Kazufumi Tsuzaka Kazuto Yoshida Yasunori Maruo Hidenao Sasaki 《Cerebellum (London, England)》2016,15(2):190-200
To identify the most sensitive scale for use in clinical trials on multiple system atrophy (MSA), a short and sensitive scale is needed for MSA clinical trials. Potential candidates are the Unified MSA Rating Scale (UMSARS), Scale for the Assessment and Rating of Ataxia (SARA), Berg Balance Scale (BBS), MSA Health-Related Quality of Life scale (MSA-QoL), and Scales for Outcomes in Parkinson’s Disease–Autonomic questionnaire (SCOPA-AUT). We enrolled patients with MSA from eight hospitals in Hokkaido, Japan. Board-certified neurologists assessed each patient at 6-month intervals and scored them on the UMSARS, SARA, BBS, MSA-QoL, and SCOPA-AUT. Score changes were evaluated using the standardized response mean (SRM). The correlation between disease duration and each score was examined. The first evaluation was conducted on 85 patients (60 patients with MSA cerebellar ataxia dominant subtype [MSA-C] and 25 patients with MSA Parkinsonism-dominant subtype [MSA-P]). Sixty-nine patients were examined after 6 months and 63 patients after 12 months. The UMSARS Part 4 had the largest SRM after 6 months and the SARA after 12 months. SRMs for MSA-P, the shorter duration group, and the early-onset group were larger than were those for MSA-C, the longer duration group, and the late-onset group. SRMs for items regarding skilled hand activities, walking, and standing were relatively large. Our study indicates that the UMSARS (parts 2 and 4), SARA, and BBS are sensitive scales for evaluating MSA progression over 12 months. Items with large SRMs effectively evaluated short-term changes. 相似文献
100.
Kakehashi Hidenao Doi Takahiro Wada Misato Kamata Tooru Shima Noriaki Miyake Akari Nitta Atsushi Asai Ryutaro Fujii Shihoko Matsuta Shuntaro Sasaki Keiko Kamata Hiroe Nishioka Hiroshi Miki Akihiro Hasegawa Hiroshi Katagi Munehiro 《Forensic Toxicology》2022,40(1):75-87
Forensic Toxicology - N-tert-Butoxycarbonylmethamphetamine (BocMA), a masked derivative of methamphetamine (MA), converts into MA under acidic condition and potentially acts as a precursor to MA... 相似文献