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81.
[目的]了解中国拉萨SOS儿童村儿童的膳食结构及营养状况,并根据膳食调查结果和存在的问题,提出合理膳食建议。[方法]2005年12月采用食物称重法,对中国拉萨SOS儿童村负责供养168名4~16岁儿童的17户家庭进行了为期5 d的膳食调查。[结果]17户家庭中绝大部分家庭膳食模式不尽合理,油脂摄入过多,大部分家庭脂肪供热百分比﹥30%;动物性食品摄入量及品种偏少,致使所有家庭的钙摄入量普遍不足,70%左右家庭的核黄素、40%左右家庭的蛋白质摄入量不足;多数家庭维生素A和铁虽然超出供给量标准,但是来源于动物性食品的比例很低。[结论]膳食模式的不合理性,势必影响儿童的正常发育和身心健康。因此,进一步加强营养知识的传授显得极为迫切和必要。 相似文献
82.
目的:观察lrigl基因在食管鳞癌中的表达及意义.方法:采用RT.PCR检测36例食管鳞状细胞癌癌组织、相应的癌旁组织和远癌组织中lriglmRNA的表达情况.PCR产物经凝胶电泳,比较3种组织中ragl与GAPDH条带的灰度值之比,半定量分析IriglmRNA的表达水平.结果:36例食管癌组织中有15例(42%)lriglmRNA检测到阳性表达,21例(58%)lriglmRNA表达缺失,其阳性表达率低于相应的癌旁组织(92%)和远癌组织(100.0%,P〈0.05);癌组织中lriglmRNA表达水平(0.76±0.22)低于相应的癌旁组织(0.89±0.33)和远癌组织(1.13±0.40);随着肿瘤分化程度的升高,lriglmRNA在癌组织中的阳性表达率也增加(P〈0.05),但lriglmRNA表达缺失与食管癌临床分期(TNM),淋巴结有无转移和病理类型均无统计学差异(P〉0.05).结论:lriglmRNA在食管癌组织中存在表达缺失和低表达,提示Irigl基因在食管癌的发生发展中可能具有抑癌基因的作用. 相似文献
83.
84.
Adrenal and ovarian steroid hormone responses to gonadotropin-releasing hormone agonist treatment in polycystic ovary syndrome. 总被引:4,自引:0,他引:4
It has been postulated that in polycystic ovary syndrome ovarian steroids can influence adrenal steroidogenesis. To test this hypothesis, basal and dexamethasone-suppressed-corticotropin-stimulated steroid hormone responses were compared among three groups of women before, during, and after gonadotropin-releasing hormone agonist treatment for 3 months. The groups were characterized as follows: (1) women with polycystic ovary syndrome with high dehydroepiandrosterone sulfate levels (greater than 400 micrograms/dl), (2) women with polycystic ovary syndrome with normal dehydroepiandrosterone sulfate levels (less than 300 micrograms/dl), and (3) normal ovulatory women. In response to gonadotropin-releasing hormone agonist, basal serum luteinizing hormone, follicle-stimulating hormone, estradiol, estrone, 17-hydroxyprogesterone, androstenedione, and testosterone in all three groups were suppressed to similar levels. Basal serum dehydroepiandrosterone sulfate levels in the group with high levels declined, but they did not reach the normal, unaltered concentrations in the other two groups. Two subjects with polycystic ovary syndrome in this group with high levels, who showed the greatest declines in basal serum dehydroepiandrosterone sulfate levels (34%, 40%), also had evidence of 3 beta-hydroxysteroid dehydrogenase deficiency before treatment, which was resolved by the end of treatment. In both groups with polycystic ovary syndrome, the increase in maximum incremental rise of dehydroepiandrosterone and dehydroepiandrosterone sulfate levels in response to a pharmacologic dose of corticotropin from a dexamethasone-suppressed baseline (adrenal androgen capacity) remained unaltered during gonadotropin-releasing hormone agonist administration. We conclude that ovarian steroids may promote excessive adrenal androgen secretion in women with polycystic ovary syndrome, may induce 3 beta-hydroxysteroid dehydrogenase deficiency as a mechanism for adrenal involvement in some women with polycystic ovary syndrome, and do not influence adrenal androgen capacity. 相似文献
85.
Bradyarrhythmias and Laparoscopy: A Prospective Study of Heart Rate Changes with Laparoscopy 总被引:1,自引:0,他引:1
Paul S. Myles DipRACOG DA 《The Australian & New Zealand journal of obstetrics & gynaecology》1991,31(2):171-173
Cardiac arrhythmias are a common complication of laparoscopy. Brady-arrhythmias (including asystole) may be life-threatening. The recent introduction of new shorter-acting muscle relaxants (atracurium and vecuronium), with their lack of vagolytic activity, may exacerbate this situation. At the Royal Women's Hospital there have been several episodes of severe bradyarrhythmias and/or asystole associated with these relaxants. This study evaluated heart rate changes in 49 women during laparoscopy: 47% of patients had arrhythmias, 30% of these being bradyarrhythmias. Nearly all the episodes occurred during carbon dioxide insufflation or with traction on pelvic structures. The life-threatening nature of this phenomenon should be understood by all anaesthetists and gynaecologists engaged in laparoscopic procedures. 相似文献
86.
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88.
The incidence of atrial fibrillation (AF) is increasing in many countries along with aging demographics. Atrial fibrillation is clearly associated with an increased rate of stroke. Numerous large clinical trials have shown that dose-adjusted warfarin can reduce the stroke rate in these patients, particularly in the elderly, and clear guidelines for the use of anticoagulants in such patients have been published. However, many studies show that treatment rates remain disappointingly low (< or = 50%). Numerous barriers to the use of dose-adjusted warfarin exist, including practical, patient-, physician-, and healthcare system-related barriers. These include the complex pharmacokinetics of warfarin, the need for continuous prothrombin time monitoring and dose adjustments, bleeding events, noncompliance, drug interactions, and increased costs of monitoring and therapy. Possible solutions to this problem are discussed and include improved patient and physician education, the use of anticoagulation clinics, new approaches to AF, and potential treatment improvements through use of newer anticoagulants. 相似文献
89.
目的构建可用于高通量筛选JAK/STAT6信号传导通路抑制剂的工程细胞株,建立稳定可靠的筛选方法。方法利用基因重组和转染技术,将STAT6特异性识别启动子IgE基因序列和虫荧光素酶报告基因联合插入pCMV质粒,脂质体法转染至HeLa细胞,经潮红霉素B抗性筛选及报告基因检测,得到稳定表达虫荧光素酶的工程细胞株。通过优化溶剂DMSO浓度,IL4作用浓度及孵育时间等筛选条件,建立了可靠的筛选方法,并在此基础上对1600种化合物进行了筛选。结果建立的筛选方法稳定可靠,系统Z′因子达到0.64。通过对1600种化合物的筛选,得到3个抑制效果较理想的化合物并测得其IC50值。结论所建立的高通量筛选方法可用于JAK/STAT6信号传导通路抑制剂的筛选。 相似文献
90.
Michaloudis D Fraidakis O Petrou A Farmakalidou H Neonaki M Christodoulakis M Flossos A Bakos P Melissas J 《Obesity surgery》2000,10(3):220-229
Background: The authors determined prospectively the safety of continuous spinal anesthesia combined with general anesthesia
and the efficacy of postoperative pain relief with continuous spinal analgesia for morbidly obese patients undergoing vertical
banded gastroplasty. Methods: 27 patients (13 men, 14 women) with a mean body mass index (BMI) of 50.4 ± 7.8 and several co-morbidities
were studied. All patients were anesthetized with the same anesthetic regimen, which included midazolam, fentanyl, propofol,
muscle relaxants, N2O, isoflurane and intrathecal bupivacaine. Postoperative pain relief was provided for 5 days and all patients received the
same regimen, which included intrathecal bupivacaine, fentanyl and intravenous tenoxicam. The intrathecal analgesic regimen
was administered continuously through a pump which had the facility of providing bolus doses when requested in predetermined
lockout intervals. Intra-operative monitoring included hemodynamic and respiratory parameters. Additional postoperative monitoring
included respiratory rate, degree of sedation, sensory level of anesthesia, motor response and intensity of pain. Results:
Intraoperative anesthetic technique was safe and provided satisfactory results in the immediate postoperative period. Furthermore,
the postoperative analgesia regimen provided effective analgesia in all patients.The mean doses of fentanyl and bupivacaine
infused intrathecally for the first 24 postoperative hours were 14.1 ± 2.0 μg.h-1 and 0.7 ± 0.1 mg.h-1 respectively, while the requirements of anal gesia decreased progressively with time. The technique provided effective analgesia
with low pain scores, which was reflected by ease in mobilizing and performing physical exercises with the physiotherapist.
Only minor complications related to anesthesia and analgesia were encountered. Conclusion: To our knowledge, this technique
of anesthesia and postoperative analgesia has not been described before in morbidly obese patients. This regimen merits further
controlled trials to establish its place in the perioperative management of morbidly obese patients. 相似文献