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81.
82.
Alon Unger Ridalva D. M. Felzemburgh Robert E. Snyder Guilherme S. Ribeiro Sharif Mohr Vinícius B. A. Costa Astrid X. T. O. Melendez Renato B. Reis Francisco S. Santana Lee W. Riley Mitermayer G. Reis Albert I. Ko Pau da Lima Urban Health Team 《Journal of urban health》2015,92(3):446-459
Low- and middle-income countries account for the majority of hypertension disease burden. However, little is known about the distribution of this illness within subpopulations of these countries, particularly among those who live in urban informal settlements. A cross-sectional hypertension survey was conducted in 2003 among 5649 adult residents of a slum settlement in the city of Salvador, Brazil. Hypertension was defined as either an elevated arterial systolic (≥140 mmHg) or diastolic (≥90 mmHg) blood pressure. Sex-specific multivariable models of systolic blood pressure were constructed to identify factors associated with elevated blood pressure. The prevalence of hypertension in the population 18 years and older was 21 % (1162/5649). Men had 1.2 times the risk of hypertension compared with women (95 % confidence intervals (CI), 1.05, 1.36). Increasing age and lack of any schooling, particularly for women, were also significantly associated with elevated blood pressure (p < 0.05). There was also a direct association between men who were black and an elevated blood pressure. Among those who were hypertensive, 65.5 % were aware of their condition, and only 36.3 % of those aware were actively using anti-hypertensive medications. Men were less likely to be aware of their diagnosis or to use medications (p < 0.01 for both) than women. The prevalence of hypertension in this slum community was lower than reported frequencies in the non-slum population of Brazil and Salvador, yet both disease awareness and treatment frequency were low. Further research on hypertension and other chronic non-communicable diseases in slum populations is urgently needed to guide prevention and treatment efforts in this growing population. 相似文献
83.
Diana Azevedo Jennifer Mancio Guilherme Pessoa-Amorim David Monteiro Nuno Almeida Ricardo Ladeiras-Lopes Rita Faria Nuno Ferreira Luís Vouga Vasco Gama Ribeiro Adelino Leite-Moreira Nuno Bettencourt 《Revista portuguesa de cardiologia》2021,40(3):153-164
Introduction and objectivesIn severe aortic stenosis (AS), the impact of aortic valve replacement (AVR) on left ventricular (LV) systolic function assessed by strain and measured by echocardiography or cardiac magnetic resonance (CMR) has been controversial. We aimed to investigate LV systolic myocardial function changes six months after AVR using global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain derived from CMR imaging.MethodsWe included 39 severe AS patients (69.3±7.8 years; 61.5% male) with preserved LV ejection fraction (LVEF) who were recruited as part of the EPICHEART study and underwent successful AVR (aortic valvular area: 0.8 cm2 (IQR: 0.2) pre- to 1.8 cm2 (IQR:0.5) post-AVR). Structural and functional parameters were assessed at baseline and six months after AVR, including LV GRS, GCS and GLS analysis by CMR, using cine short-axial and two-, three-, and four-chamber long-axial view. Comparison between baseline and postoperative LV remodeling was performed using Student t-test and Wilcoxon test.ResultsAt six-month follow-up, LV mass, end-diastolic and end-systolic volumes, stroke volume, cardiac output, lateral E/e’, tricuspid annular plane systolic excursion, right ventricular (RV) S wave velocity, GLS [-15.6% (IQR: 4.39) to -13.7% (IQR: 4.62)] and GCS [-17.8±3.58% to -16.1±2.94%] reduced significantly, while LVEF and GRS remained unchanged and lateral e’ velocity increased.ConclusionsDespite favorable reverse LV structural and diastolic functional remodeling six months following AVR, GLS and GCS assessed by CMR reduced compared to baseline, LVEF remained unchanged. The clinical utility and timing of assessment of postoperative strain changes as a marker of systolic function progression needs further research. 相似文献
84.
Padrão Eduardo Messias Hirano Bustos Brian Mahesh Ashwin Fonseca Guilherme Henrique Hencklain Taniguchi Leandro Utino 《Annals of hematology》2022,101(9):1951-1957
Annals of Hematology - Sickle cell disease (SCD) is associated with multiple known complications and increased mortality. This study aims to further understand the profile of intensive care unit... 相似文献
85.
Oliveira Bruno R. R. Lattari Eduardo Pires Flávio O. Viana Bruno F. Machado Sérgio Rodrigues Guilherme M. Oliveira Izaildo A. Santos Tony M. 《Sport Sciences for Health》2022,18(1):211-217
Sport Sciences for Health - To compare the intensity and duration self-selected by participants with higher and lower cardiorespiratory fitness to that recommended by the American College of Sports... 相似文献
86.
Guilherme V. Silva Emerson C. Perin James T. Willerson 《Current cardiovascular risk reports》2008,2(5):342-349
Cardiac repair with cell-based therapy is a promising treatment for patients with coronary heart disease. Preclinical and
early clinical studies have shown that stem cell therapy is safe and effective in improving left ventricular function and
myocardial perfusion. Specifically, cardiac stem cell therapy may be beneficial in reducing left ventricular remodeling in
patients with myocardial infarction and in improving symptoms and preventing cardiac enlargement in patients with chronic
ischemic heart disease. Although not well defined, multiple mechanisms, including paracrine effects, probably contribute to
stem cell-mediated cardiac repair. The issues of timing, mode of delivery, and cell dose need to be systematically studied
to maximize benefits. Nevertheless, rapid advancements may soon make cardiac stem cell therapy a central part of the treatment
regimen for patients with coronary heart disease. 相似文献
87.
Claudia R. L. Cardoso Juliana V. Melo Guilherme C. Salles Nathalie C. Leite Gil F. Salles 《Diabetologia》2018,61(11):2266-2276
Aims/hypothesis
The prognostic importance of the ankle–brachial index (ABI) in individuals with diabetes is controversial. We aimed to evaluate the relationship between the ABI and the occurrence of micro- and macrovascular complications in individuals with type 2 diabetes.Methods
The ABI was measured at baseline in 668 individuals with type 2 diabetes, and the individuals were followed-up for a median of 10 years. Multivariate Cox analysis was used to examine associations between the ABI and the occurrence of microvascular (retinopathy, microalbuminuria, renal function deterioration and peripheral neuropathy) and macrovascular (total cardiovascular events, major adverse cardiovascular events [MACE] and cardiovascular mortality) complications, and all-cause mortality. The improvement in risk stratification was assessed using the C statistic and the integrated discrimination improvement (IDI) index.Results
During follow-up, 168 individuals had a cardiovascular event (140 MACE) and 191 individuals died (92 cardiovascular deaths); 156 individuals newly developed or experienced worsening diabetic retinopathy, 194 achieved the renal composite outcome (122 with newly developed microalbuminuria and 93 with deteriorating renal function) and 95 newly developed or experienced worsening peripheral neuropathy. The ABI, either analysed as a continuous or as a categorical variable, was significantly associated with all macrovascular and mortality outcomes, except for non-cardiovascular mortality. Individuals with a baseline ABI of ≤0.90 had a 2.1-fold increased risk of all-cause mortality (95% CI 1.3, 3.5; p?=?0.004), a 2.7-fold excess risk of cardiovascular mortality (95% CI 1.4, 5.4; p?=?0.004) and a 2.5-fold increased risk of MACE (95% CI 1.5, 4.4; p?=?0.001). The ABI improved risk discrimination over classical risk factors, with relative IDIs ranging from 6.3% (for all-cause mortality) to 31% (for cardiovascular mortality). In addition, an ABI of ≤0.90 was associated with the development or worsening of peripheral neuropathy (2.1-fold increased risk [95% CI 1.1, 4.3]; p?=?0.033), but not with retinopathy or renal outcomes.Conclusions/interpretation
A low ABI is associated with excess risk of adverse cardiovascular outcomes, mortality and peripheral neuropathy development or worsening, and improves cardiovascular risk stratification. The ABI should therefore be routinely evaluated in individuals with type 2 diabetes.88.
Guilherme Silva Torrezan Carlos Roberto Polaquini Marcelo Freitas Lima Luis Octavio Regasini 《Sustainable Chemistry and Pharmacy》2020
Glycerol is the main co-product from biodiesel production and has been recognized as a sustainable solvent. Herein, we used glycerol and waste glycerol in synthesis of two bioactive α,β-unsaturated ketones (E,E)-1,5-diphenylpenta-2,4-dien-1-one (1) and (E,E)-2,6-dibenzylidenecyclohexanone (2), using aldol mono- and di-condensation reactions, respectively. Crude yield values were calculated from product mass after precipitation and drying. Purity was measured by High Performance Liquid Chromatography with Photodiode Array (HPLC-PAD) using analytical curves and reference compounds. Glycerol and waste glycerol were able to furnish 1 and 2 in higher crude yields and HPLC-PAD purities values than other protic solvents (ethanol, methanol, PEG-400 and water). In order to investigate reasons of glycerol efficiency when compared to water efficiency, we performed computational calculations using Density Functional Theory (DFT). Theoretical predictions confirmed the E1cB mechanism, as well as favourable energy barrier using glycerol in comparison to water, corroborating their sustainable properties. In addition, waste glycerol from corn and sunflower oil transesterifications were used in the synthesis of 1 and 2 for four recycles, displaying good crude yields and HPLC-purities. 相似文献
89.
Flor M. Perez‐Campo Guilherme Costa Michael Lie‐a‐Ling Valerie Kouskoff Georges Lacaud 《Immunology》2013,139(2):161-165
The MOnocytic leukaemia Zing finger (MOZ; MYST3 or KAT6A1) gene is frequently found translocated in acute myeloid leukaemia. MOZ encodes a large multidomain protein that contains, besides others, a histone acetyl transferase catalytic domain. Several studies have now established the critical function of MOZ in haematopoiesis. In this review we summarize the recent findings that underscore the relevance of the different biological activities of MOZ in the regulation of haematopoiesis. 相似文献
90.
J.A. Machado M.F. Ghizoni J. Bertelli Gabriel C. Teske Guilherme C. Teske D.F. Martins L. Mazzardo-Martins E. Cargnin-Ferreira A.R.S. Santos A.P. Piovezan 《Brazilian journal of medical and biological research》2013,46(11):929-935
The rat models currently employed for studies of nerve regeneration present distinct
disadvantages. We propose a new technique of stretch-induced nerve injury, used here
to evaluate the influence of gabapentin (GBP) on nerve regeneration. Male Wistar rats
(300 g; n=36) underwent surgery and exposure of the median nerve in the right
forelimbs, either with or without nerve injury. The technique was performed using
distal and proximal clamps separated by a distance of 2 cm and a sliding distance of
3 mm. The nerve was compressed and stretched for 5 s until the bands of Fontana
disappeared. The animals were evaluated in relation to functional, biochemical and
histological parameters. Stretching of the median nerve led to complete loss of motor
function up to 12 days after the lesion (P<0.001), compared to non-injured nerves,
as assessed in the grasping test. Grasping force in the nerve-injured animals did not
return to control values up to 30 days after surgery (P<0.05). Nerve injury also
caused an increase in the time of sensory recovery, as well as in the electrical and
mechanical stimulation tests. Treatment of the animals with GBP promoted an
improvement in the morphometric analysis of median nerve cross-sections compared with
the operated vehicle group, as observed in the area of myelinated fibers or
connective tissue (P<0.001), in the density of myelinated fibers/mm2
(P<0.05) and in the degeneration fragments (P<0.01). Stretch-induced nerve
injury seems to be a simple and relevant model for evaluating nerve regeneration. 相似文献