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21.
Evaluation of micro-CT for emphysema assessment in mice: comparison with non-radiological techniques
Artaechevarria X Blanco D de Biurrun G Ceresa M Pérez-Martín D Bastarrika G de Torres JP Zulueta JJ Montuenga LM Ortiz-de-Solorzano C Munoz-Barrutia A 《European radiology》2011,21(5):954-962
Objectives
To define the potential, limitations and synergies of micro-CT and other non-radiological techniques for the quantification of emphysema and related processes in mice, by performing a complete characterization of the elastase-induced emphysema model.Materials and methods
Ninety A/J mice (45 treated and 45 controls) were studied at different time points using breath-hold gated micro-CT, functional test parameters, RT-PCR for RNA cytokine expression, Luminex technology for cytokine plasma concentration and histomorphometry.Results
Both histomorphometry and micro-CT imaging reflect rapid initial emphysema progression followed by steady-state development at decreasing rates. Cytokine measurements reveal an acute inflammatory response within the first 24?h that disappears after the first week. Limited systemic effect was observed based on plasma cytokine concentration. Lung compliance decreases during the acute inflammation phase and increases afterwards.Conclusion
Histomorphometry is the most sensitive technique since it detects airspace enlargement before the other methods (1?h after treatment). Micro-CT correlates well with histology (r2?=?0.63) proving appropriate for longitudinal studies. Functional test parameters do not necessarily correlate with the extent of emphysema, as they can be influenced by acute inflammation. Finally, cytokine measurements correlate with the presence of inflammation in histology but not with emphysema. 相似文献22.
Xabier Artaechevarria David Blanco Daniel Pérez-Martín Gabriel de Biurrun Luis M. Montuenga Juan P. de Torres Javier J. Zulueta Gorka Bastarrika Arrate Muñoz-Barrutia Carlos Ortiz-de-Solorzano 《European radiology》2010,20(11):2600-2608
Objectives
To evaluate the feasibility of using automatic quantitative analysis of breath hold gated micro-CT images to detect and monitor disease in a mouse model of chronic pulmonary inflammation, and to compare image-based measurements with pulmonary function tests and histomorphometry. 相似文献23.
24.
Eduardo Anitua PhD MD Roberto Prado PhD Gorka Orive PhD 《Clinical implant dentistry and related research》2012,14(1):51-60
Purpose: The purpose of this study was to evaluate the potential effects of plasma rich in growth factors (PRGF) technology and its autologous formulations in five consecutive patients in which bilateral sinus lift augmentation was carried out. Material and Methods: Five consecutive patients received bilateral sinus floor augmentation. All patients presented a residual bone height of class D (1–3 mm). The effects of PRGF combined with bovine anorganic bone (one side) were compared with the biomaterial alone (contralateral side). The effects of using liquid PRGF to maintain the bone window and autologous fibrin membrane to seal the defect were evaluated. A complete histological and histomorphometrical analysis was performed 5 months after surgery. Results: One patient was excluded from the study as the Schneiderian membrane of the control side was perforated during the surgery. In two patients, the biopsies obtained from the control sides 5 months postsurgery were not acceptable for processing. PRGF technology facilitated the surgical approach of sinus floor elevation. The control area was more inflamed than the area treated with PRGF technology. Patients referred also to an increased sensation of pain in the control area. PRGF‐treated samples had more new vital bone than controls. In patient number 1, image processing revealed 21.4% new vital bone in the PRGF area versus 8.4% in the control area, whereas in patient number 2, 28.4% new vital bone was quantified in the PRGF area compared with the 8.2% of the control side. The immunohistochemical processing of the biopsies revealed that the number of blood vessels per square millimeter of connective tissue was 116 vessels in the PRGF sample versus 7 in the control biopsy. Conclusions: These preliminary results suggest that from a practical point of view, PRGF may present a role in reducing tissue inflammation after surgery, increasing new bone formation and promoting the vascularization of bone tissue. 相似文献
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Torrecilla García M Domínguez Grandal F Torres Lana A Cabezas Peña C Jiménez Ruiz CA Barrueco Ferrero M Solano Reina S de Granda Orive JI Díaz-Maroto Muñoz JL Alonso J Martínez ML García S de la Cruz Amorós E Abengozar Muela R Ramos Postigo F Ayesta J 《Atencion primaria / Sociedad Espa?ola de Medicina de Familia y Comunitaria》2002,30(5):310-317
27.
Lung cancer is the leading cause of cancer death. A number of screening trials have been carried out over the past two decades and have failed to demonstrate a reduction of lung cancer-related mortality. Recent advances in new forms of technology--spiral low-dose CT--have resuscitated interest in screening programs. Preliminary results are promising but the outstanding question is whether the magnitude of improvement is sufficient to affect a measurable reduction in lung cancer mortality? 相似文献
28.
Cuadrado A Orive A García-Suárez C Domínguez A Fernández-Escalante JC Crespo J Pons-Romero F 《Obesity surgery》2005,15(3):442-446
Non-alcoholic fatty liver disease (NAFLD) is characterized by an excessive accumulation of fatty acids and triglycerides within
the cytoplasm of the hepatocytes of non-alcohol users. The natural history varies according to the initial histological diagnosis.
A current consideration is that cryptogenic cirrhosis may be representative of a late stage of non-alcoholic steatohepatitis
(NASH), which has lost its features of necroinflammatory activity and steatosis in up to 80% of patients. Since NASH is able
to progress to cirrhosis, hepatocellular carcinoma (HCC) development may be an end-stage of this disease. We report below
two clinical cases of patients diagnosed with NASH who developed HCC. The relationship between NAFLD and HCC is reviewed. 相似文献
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