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151.
Michael R. Narkewicz Simon Horslen Regina M. Hardison Benjamin L. Shneider Norberto Rodriguez-Baez Estella M. Alonso Vicky L. Ng Mike A. Leonis Kathleen M. Loomes David A. Rudnick Philip Rosenthal Rene Romero Girish C. Subbarao Ruosha Li Steven H. Belle Robert H. Squires 《Clinical gastroenterology and hepatology》2018,16(11):1801-1810.e3
152.
Ray U Khan GA Chakraborty K Basuroy S Patra SC Girish G Bhattacharya G Sinha AK 《Journal of thrombosis and thrombolysis》2012,33(3):218-229
Insulin inhibits platelet aggregation through nitric oxide synthesis by stimulating platelet insulin activated nitric oxide
synthase. Impaired platelet insulin activated nitric oxide synthase in acute myocardial infarction (AMI) patients had been
reported and thus our aim was to identify and isolate the factors impairing insulin activated nitric oxide in acute myocardial
infarction patients’ plasma and study its effect on platelets aggregation in vitro. The insulin activated nitric oxide synthase
inhibitor was identified as a protein and was purified from the plasma of AMI subjects using DEAE cellulose and Sephadex G-50
column, molecular weight determined by SDS-PAGE, nitric oxide quantified by methaemoglobin method, inhibitor protein quantified
in plasma by immunoblot and ELISA, platelet aggregation studies done using an aggregometer, thromboxane-A2 in the platelets
determined by radioimmunoassay, 125I-insulin radioligand binding studies done using normal subject platelets. The purified nitric oxide synthase inhibitor protein
was ~66 kDa, concentration in AMI subjects’ plasma varied from 114 to 9,090 μM and was undetected in normal subjects’ plasma.
The inhibitor protein competes with insulin for insulin receptor binding sites. The Incubation of the normal subject PRP with
5.0 μM inhibitor for 30 min followed by 0.4 μM ADP addition caused platelet aggregation in vitro, 130 μM aspirin or 400 μU
insulin/ml addition was able to abrogate 0.4 μM ADP induced platelet aggregation even in the presence of 5.0 μM inhibitor.
A potent inhibitory protein against insulin activated nitric oxide synthase in platelets appears in circulation of AMI subjects
impairing nitric oxide production, potentiating ADP induced platelet aggregation and increasing the thromboxane-A2 level in
platelets. 相似文献
153.
Brahme Radhika Mamulwar Megha Rahane Girish Jadhav Sachin Panchal Narayan Yadav Rajesh Gangakhedkar Raman 《Indian journal of pediatrics》2020,87(4):275-280
Indian Journal of Pediatrics - Youth and adolescents are the priority population to target the interventions as risky behaviors persist and they contribute to almost half of the new Human... 相似文献
154.
Gupta Tejpal Maitre Madan Gupta Priyamvada Krishnatry Rahul Chatterjee Abhishek Moiyadi Aliasgar Shetty Prakash Singh Vikas Chinnaswamy Girish Epari Sridhar Sahay Ayushi Patil Vijay GodaSastri Jayant 《Journal of neuro-oncology》2020,147(2):405-415
Journal of Neuro-Oncology - To report clinical outcomes of salvage re-irradiation (re-RT) in recurrent/progressive ependymoma. Medical records of patients treated with curative-intent re-RT as... 相似文献
155.
Lung cancer is a leading cause of cancer deaths and the incidence is rising. Most patients with lung cancer present to the clinician in a fairly advanced stage and at best only 25-30% of patients can be offered curative resection. Screening tests using sputum cytology and chest radiograph have been used with limited success. Value of low dose spiral CT scan as screening tool for lung cancer is being evaluated and its limitations include high costs, need for repeated scanning and necessity to obtain histological confirmation with additional procedures. There have been significant advances in the early diagnosis of lung cancer in high risk patient groups using bronchoscopic methods such as white light bronchoscopy, autofluorescence bronchoscopy, high magnification bronchoscopy, narrow band imaging and endobronchial ultrasound. These techniques appear to be promising tools as they might allow to visualise changes of early lung cancer and also permit sampling for histological confirmation. 相似文献
156.
The p53 tumor-suppressor protein plays an integral role in apoptosis. Perturbations in peripheral lymphocyte (PL) apoptosis
may be associated with rheumatoid arthritis (RA). Polymorphisms at codon 72 of p53 (arginine (Arg72) to proline transition)
confers differences in mitochondrial translocation and apoptosis inducing capabilities of p53 in vitro. We examined associations
of this polymorphism with PL apoptosis, mitochondrial depolarization, and clinical markers of disease activity in a cohort
of black South African RA patients. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism.
PL apoptosis was measured using the annexin-V assay and mitochondrial membrane potential with the JC-1 assay. Clinical and
laboratory parameters were recorded for all patients. Statistical differences in these parameters were investigated according
to genotype. Genotype distribution did not differ significantly between RA patients and controls (Arg/Arg, Arg/Pro, Pro/Pro:
12%, 46%, and 42% versus 3%, 34%, and 63%), despite significantly higher frequency of the Arg72 allele in patients (p = 0.0406). There was no significant difference in PL apoptosis and mitochondrial depolarization based on p53 codon 72 genotype.
In addition, clinical markers of disease activity were not significantly different between genotypes. We conclude that p53
codon 72 genotype does not influence PL apoptosis or mitochondrial depolarization and is not associated with clinical markers
of disease in RA. 相似文献
157.
158.
Habte HH Kotwal GJ Lotz ZE Tyler MG Abrahams M Rodriques J Kahn D Mall AS 《Neonatology》2007,92(2):96-104
Human breast milk is known to contain numerous biologically active components which protect breast fed infants against microbes, viruses, and toxins. The purpose of this study was to purify and characterize the breast milk mucin and determine its anti-poxvirus activity. In this study human milk mucin, free of contaminant protein and of sufficient quantity for further analysis, was isolated and purified by Sepharose CL-4B gel filtration and cesiumchloride density-gradient centrifugation. Based on the criteria of size and appearance of the bands and their electrophoretic mobility on sodium dodecyl sulfate polyacrylamide-gel electrophoresis, Western blotting together with the amino acid analysis, it is very likely that the human breast milk mucin is MUC1. It was shown that this breast milk mucin inhibits poxvirus activity by 100% using an inhibition assay with a viral concentration of 2.4 million plaque-forming units/ml. As the milk mucin seems to aggregate poxviruses prior to their entry into host cells, it is possible that this mucin may also inhibit other enveloped viruses such as HIV from entry into host cells. 相似文献
159.
Diana Magee Douglas Cheung Amanda Hird Srikala S. Sridhar Charles Catton Peter Chung Alejandro Berlin Padraig Warde Alexandre Zlotta Neil Fleshner Girish S. Kulkarni 《Canadian Urological Association journal》2022,16(4):E197
IntroductionRadical cystectomy (RC) is the historic gold standard treatment for muscle-invasive bladder cancer (MIBC), but trimodal therapy (TMT) has emerged as a valid therapeutic option for select patients. Given that prospective clinical trials have been difficult to perform in this area, our aim was to compare these two primary treatment strategies using decision analytic methods.MethodA two-dimensional Markov microsimulation model was constructed using TreeAge Pro to compare RC and TMT for patients with newly diagnosed MIBC. A comprehensive literature search was used to populate model probabilities and utilities. Our primary outcome was quality-adjusted life expectancy (QALE). Secondary outcomes included crude life expectancy (LE) and bladder cancer recurrences. The simulated patient for our model was an adult with MIBC (pT2-4 N0 M0) who was a candidate for either RC or TMT.ResultsA total of 500 000 patients were simulated. TMT resulted in an estimated mean QALE of 7.48 vs. 7.41 for RC. However, the average LE for patients treated with TMT was lower compared with RC (10.20 vs. 10.74 years). A sensitivity analysis evaluating the impact of age showed that younger patients treated with RC had greater QALE and longer LE than those treated with TMT; inverse findings were observed for elderly patients. Overall, 39.4% of patients treated with TMT experienced a bladder recurrence.ConclusionsRC results in a longer LE compared to TMT (0.54 years), but with a lower QALE (−0.07 years). The preferred treatment strategy varied with patient age. 相似文献
160.
Mohit D. Gupta M.D. D.M. Girish Mp M.D. D.M. Amit Mittal M.D. D.M. Sanjay Tyagi M.D. D.M. 《Echocardiography (Mount Kisco, N.Y.)》2010,27(9):E117-E118
A young male presented with progressively increasing breathlessness for one year. Echocardiography showed a cystic echolucent cavity in interventricular septum communicating with sinus of Valsalva. A diagnosis of unruptured aneurysm of Valsalva dissecting into the interventricular septum was made. This complication is extremely rare and early recognition may prevent a potential catastrophe. (Echocardiography 2010;27:E117‐E118) 相似文献