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951.
Jorge Meneses Nunes Fernando César Bizerra Renata Carmona e Ferreira Arnaldo Lopes Colombo 《Antimicrobial agents and chemotherapy》2013,57(1):382-389
Rhodotorula species are emergent fungal pathogens capable of causing invasive infections, primarily fungemia. They are particularly problematic in immunosuppressed patients when using a central venous catheter. In this study, we evaluated the species distribution of 51 clinical and 8 environmental Rhodotorula species isolates using the ID32C system and internal transcribed spacer (ITS) sequencing. Antifungal susceptibility testing and biofilm formation capability using a crystal violet staining assay were performed. Using ITS sequencing as the gold standard, the clinical isolates were identified as follows: 44 R. mucilaginosa isolates, 2 R. glutinis isolates, 2 R. minuta isolates, 2 R. dairenensis isolates, and 1 Rhodosporidium fluviale isolate. The environmental isolates included 7 R. mucilaginosa isolates and 1 R. slooffiae isolate. Using the ID32C system, along with a nitrate assimilation test, only 90.3% of the isolates tested were correctly identified. In the biofilm formation assay, R. mucilaginosa and R. minuta exhibited greater biofilm formation ability compared to the other Rhodotorula species; the clinical isolates of R. mucilaginosa showed greater biofilm formation compared to the environmental isolates (P = 0.04). Amphotericin B showed good in vitro activity (MIC ≤ 1 μg/ml) against planktonic cells, whereas voriconazole and posaconazole showed poor activity (MIC50/MIC90, 2/4 μg/ml). Caspofungin and fluconazole MICs were consistently high for all isolates tested (≥64 μg/ml and ≥ 4 μg/ml, respectively). In this study, we emphasized the importance of molecular methods to correctly identify Rhodotorula species isolates and non-R. mucilaginosa species in particular. The antifungal susceptibility profile reinforces amphotericin B as the antifungal drug of choice for the treatment of Rhodotorula infections. To our knowledge, this is the first study evaluating putative differences in the ability of biofilm formation among different Rhodotorula species. 相似文献
952.
Norberto Arístides Mezzadri Alexandra Catalina Mandry Diego Luis Sinagra Jorge Eduardo Falco Juan Manuel Fernández Vila 《Cirugía espa?ola》2010,87(5):306-311
BackgroundMalignant primary or secondary adrenal tumours are uncommon. For most of them early surgery with adrenalectomy is the only means of cure. Although controversy exists on this issue, the increasing experience in laparoscopic surgery extends the indication for laparoscopic adrenalectomy to potentially malignant and to metastatic adrenal tumours. Our aim was to evaluate the technical feasibility of laparoscopic adrenalectomy for malignant neoplasias, describing the results of our consecutive series of patients.Material and methodsWe retrospectively analysed 13 patients who underwent laparoscopic adrenalectomy for malignant neoplasia between March 1999 and June 2009, at the Hospital de Clínicas of the Universidad of Buenos Aires and at the Hospital Alemán of Buenos Aires. A transperitoneal laparoscopic approach was used in all patients. The mean follow up was 37.9 months (2–84).ResultsThirteen laparoscopic adrenalectomies were performed due to malignant neoplasia. Mean age was 55.2+12 years. The relationship between male and female was 10/3. Five patients had an adrenal carcinoma, 1 patient a malignant phaeochromocytoma, and 7 patients had metastatic tumours. Three patients required conversion to laparotomy. Average operation time was 146.4 min. There were two perioperative complications and no mortality. Average length of hospital stay was 4.6 days (1–35). The survival at 3 years was 46%. The cause of death was the underlying disease in all cases.ConclusionLaparoscopic adrenalectomy is a reasonable technique for malignant adrenal tumours, when the open oncological resection can be reproduced by the laparoscopic approach. 相似文献
953.
The cure for type 1 diabetes (T1D) will require either the replacement or regeneration of insulin-producing cells, together with measures that prevent their immune-mediated destruction. Experiments in rodent models have found that pancreatic stem cells, committed progenitors and replicating beta-cells can all contribute to insulin-producing cell regeneration. The cellular and molecular mechanisms of these cells, both in vitro and in vivo, have been investigated by us and by others. Furthermore, our surgical research laboratory has developed a unique in vivo chamber model of T1D, allowing the assessment of the behaviour of different sources of insulin-producing cells with a view to their potential use in cell-based therapies. 相似文献
954.
Effects of attention deficit hyperactivity disorder signs and socio‐economic status on sleep bruxism and tooth wear among schoolchildren: structural equation modelling approach 下载免费PDF全文
Isabella Mota‐Veloso Roger Keller Celeste Cynthia Pimenta Fonseca Maria Eliza Consolação Soares Leandro Silva Marques Maria Letícia Ramos‐Jorge Joana Ramos‐Jorge 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2017,27(6):523-531
955.
Marilia Henrique Destefani Jorge Elias Annelise Manzano Serra Negra Trazzi Plinio Prizon Kajiwara Aila Ferreira de Menezes Rodolfo Borges dos Reis Valdair Francisco Muglia 《Ultrasound in medicine & biology》2017,43(10):2167-2173
We correlated contrast-enhanced cross-sectional imaging and outcomes to assess the reproducibility of ultrasonographic criteria for renal minimally complex (MC) cysts. From 2003 to 2015, 143 cysts were described as complex or MC by ultrasound (US). After exclusions, 98 US studies were retrospectively evaluated and compared with computed tomography (CT)/magnetic resonance imaging (MRI). At sonography, 51 were MC cysts and 47 were complexes according to two independent observers. Inter-observer agreement for US was 0.704 and 0.745 for CT/MRI. Of 51 cysts classified as MC by US, 38 were Bosniak I/II and 6 were Bosniak IIF by CT/MRI. In 7, there were no cross-sectional images; however, they were stable for at least 2 y. Of 47 complex cysts, 9 were Bosniak II, 22 Bosniak IIF, 8 Bosniak III and 8 Bosniak IV. No Bosniak III/IV cysts by CT/MRI were classified as MC by US. Our results indicate that US offers reproducible criteria for MC cysts and may be used alone for these lesions. 相似文献
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959.
Elena Sobrino‐Fernández M.D. Minia Campos‐Domínguez M.D. Ph.D. Rebeca Gregorio‐Hernández M.D. Jorge Huerta‐Aragonés M.D. Cristina Beléndez‐Bieler M.D. Ángel Lancharro‐Zapata M.D. María Luisa Franco‐Fernández M.D. Belén Bernardo‐Atienza M.D. Manuel Sánchez‐Luna M.D. Ph.D. 《Pediatric dermatology》2017,34(3):e128-e129
We describe the case of a 33‐week preterm infant who developed nonimmune hydrops fetalis secondary to a kaposiform hemangioendothelioma (KHE). The tumor was successfully treated with vincristine, prednisone, ticlopidine, and aspirin. KHE can be an unusual cause of hydrops fetalis; in such cases, diagnosis can be challenging since generalized edema can obscure KHE. 相似文献
960.
Lilian Martins Oliveira Diniz Tiago Guimar?es Maria das Gra?as Rodrigues de Oliveira Jorge Andrade Pinto Silvana Spindola de Miranda 《Jornal brasileiro de pneumologia》2014,40(2):188-192
We report a rare case in a female infant (age, 3.5 months) with primary
immunodeficiency (IFN-γ/IL-12 pathway defect) who presented with suppurative
lymphadenitis after Mycobacterium bovis BCG vaccination. The strain
of M. bovis BCG identified was found to be resistant to isoniazid
and rifampin. The patient was treated with a special pharmacological regimen
involving isoniazid (in a limited, strategic manner), ethambutol, streptomycin, and
IFN-γ, after which there was complete resolution of the lesions. 相似文献