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排序方式: 共有1759条查询结果,搜索用时 15 毫秒
31.
JEFF S. HEALEY M.D. M.Sc. LORNE J. GULA M.D. DAVID H. BIRNIE M.D. LAWRENCE STERNS M.D. STUART J. CONNOLLY M.D. JOHN SAPP M.D. EUGENE CRYSTAL M.D. CHRIS SIMPSON M.D. DEREK V. EXNER M.D. M.P.H. TERESA KUS M.D. FRANCOIS PHILIPPON M.D. GEORGE WELLS Ph.D. ANTHONY SL. TANG M.D. 《Journal of cardiovascular electrophysiology》2012,23(12):1313-1316
Comparing ICD Implantation with and Without Intraoperative Defibrillation Testing. Introduction: The need to perform defibrillation testing (DT) at the time of implantable cardioverter defibrillator (ICD) insertion is controversial. In the absence of randomized trials, some regions now perform more than half of ICD implants without DT. Methods: During the last year of enrolment in the Resynchronization for Ambulatory Heart Failure Trial, a substudy randomized patients to ICD implantation with versus without DT. Results: Among 252 patients screened, 145 were enrolled; 75 randomized to DT and 70 to no DT. Patients were similar in terms of age (65.9 ± 9.3 years vs 67.9 ± 8.9 years); LVEF (24.7 ± 4.6% vs 23.6 ± 4.6%), QRS width (154.8 ± 23.5 vs 155.8 ± 23.6 ms), and history of atrial fibrillation (5% vs 6%). All 68 patients in the DT arm tested according to the protocol achieved a successful DT (≤25 J); 96% without requiring any system modification. No patient experienced perioperative stroke, myocardial infarction, heart failure (HF), intubation or unplanned ICU stay. The length of hospital stay was not prolonged in the DT group: 20.2 ± 26.3 hours versus 21.3 ± 23.0 hours, P = 0.79. One patient in the DT arm had a failed appropriate shock and no patient suffered an arrhythmic death. The composite of HF hospitalization or all‐cause mortality occurred in 10% of patients in the no‐DT arm and 19% of patients in the DT arm (HR = 0.53, 95% CI: 0.21–1.31, P = 0.14). Conclusions: In this randomized trial, perioperative complications, failed appropriate shocks, and arrhythmic death were all uncommon regardless of DT. There was a nonsignificant increase in the risk of death or HF hospitalization with DT. (J Cardiovasc Electrophysiol, Vol. 23, pp. 1313‐1316, December 2012) 相似文献
32.
MA Suckow SL Voytik-Harbin LA Terril SF Badylak 《Journal of investigative surgery》2013,26(5):277-287
Small instestinal submucosa (SIS) is an easily produced material that has been used experimentally for tissue engineering. To evaluate the ability of SIS to facilitate bone growth within a long-bone defect, a segment of the radius was surgically removed in adult, female Sprague-Dawley rats. The defect was either left unfilled or implanted with SIS, demineralized cortical bone (DMCB), or ovalbumin. The defect was evaluated radiographically and histologically after 3, 6, 12, and 24 weeks. Tissue remodeling within the defect was evident by week 3 in SIS- and DMCB-treated rats. Filling was characterized initially by infiltration of mononuclear cells and extracellular material in SIS-implanted rats and multifocal remodeling bone particles and cartilage formation in DMCB implanted rats. Cartilage was observed as early as 3 weeks and bone as early as 6 weeks in SIS-implanted rats. Filling of the defect arose from multiple foci in DMCB-implanted rats, but was contiguous with and parallel to the ulnar shaft in SIS-implanted rats, suggesting that defect repair by SIS may be conductive rather than inductive. Rats in which the defect was left unfilled demonstrated slow but progressive filling of the defect, characterized by mononuclear cell infiltrates and fibrous extracellular material. In summary, SIS facilitated rapid filling of a longbone defect. These results suggest that SIS may be useful as a bone repair material. 相似文献
33.
Marianna LaNoue David A. Graeber Deborah L. Helitzer Jan Fawcett 《Community mental health journal》2013,49(5):560-566
Adverse childhood events (ACE’s) have been empirically related to a wide range of negative health and mental health outcomes. However, not all individuals who experience ACE’s follow a trajectory of poor outcomes, and not all individuals perceive the impact of ACE’s as necessarily negative. The purpose of this study was to investigate positive and negative affect as predictors of adults’ ratings of both the childhood and adult impact of their childhood adversity. Self-report data on ACE experiences, including number, severity, and ‘impact’ were collected from 158 community members recruited on the basis of having adverse childhood experiences. Results indicated that, regardless of event severity and number of different types of adverse events experienced, high levels of negative affect were the strongest predictor of whether the adult impact of the adverse childhood events was rated as negative. All individuals rated the childhood impact of events the same. Implications are discussed. 相似文献
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The Comprehensive Inventory of Functioning-Cancer (CIF-CA) was developed to measure actual and desired functional status in women with cancer. CIF-CA items were taken from the Inventory of Functional Status-Cancer, which measures only actual performance of usual activities. Six CIF-CA subscales measure the extent to which women perform usual personal care, family care, household, social, community, and occupational activities following diagnosis of cancer (actual functional status) and the level at which they wish to perform those activities (desired functional status). Reliability and construct validity estimates were obtained using a sample of 190 women with breast, lung, or colon cancer. Internal consistency reliability using average correlations for subscale item to subscale total scores ranged from 0.68 to 0.93 for actual functional status and from 0.61 to 0.85 for desired functional status. Internal consistency reliability coefficients for subscale to total CIF-CA scores ranged from 0.46 to 0.86 for actual functional status and from 0.62 to 0.83 for desired functional status. Initial construct validity coefficients, using subscale to subscale scores, ranged from 0.10 to 0.61 for actual functional status and from 0.33 to 0.62 for desired functional status. The data support continued development of the CIF-CA. 相似文献
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S. M. Yentis D. N. Lucas L. Brigante R. Collis P. Cowley S. Denning W. J. Fawcett A. Gibson 《Anaesthesia》2020,75(7):913-919
Serious neurological lesions such as vertebral canal haematoma are rare after obstetric regional analgesia/anaesthesia, but early detection may be crucial to avoid permanent damage. This may be hampered by the variable and sometimes prolonged recovery following ‘normal’ neuraxial block, such that an underlying lesion may easily be missed. These guidelines make recommendations for the monitoring of recovery from obstetric neuraxial block, and escalation should recovery be delayed or new symptoms develop, with the aim of preventing serious neurological morbidity. 相似文献
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Further characterization of factor VIII-deficient mice created by gene targeting: RNA and protein studies 总被引:6,自引:7,他引:6
Bi L; Sarkar R; Naas T; Lawler AM; Pain J; Shumaker SL; Bedian V; Kazazian HH Jr 《Blood》1996,88(9):3446-3450