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61.
Willaert Robin Shaheen Eman Deferm Julie Vermeersch Hubert Jacobs Reinhilde Mombaerts Ilse 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(7):1527-1532
Graefe's Archive for Clinical and Experimental Ophthalmology - Current methods to analyse the globe position, including Hertel exophthalmometry and computed tomography (CT), are limited to the... 相似文献
62.
Omnia Shafei Alyaa A. Kotby Mona M. El Ganzoury Nevin M. Habeeb Eman Elsayed 《Congenital heart disease》2022,17(2):173-185
Objectives: We aimed to evaluate the effect of percutaneous atrial septal defect (ASD) closure in children using
right heart indices and serum galectin-3 (Gal-3), as potential biomarkers of right heart remodeling. Methods: This
case–control prospective study included 40 children with ASD and 25 control subjects. An echocardiographic evaluation was performed before the procedure, as well as 24 h, 1 month, and 6 months after intervention. Serum
Gal-3 was measured before, and 1 month after the procedure. Results: Serum Gal-3 concentration, right atrial
(RA) dimensions, right ventricular (RV) dimensions, indexed RA area, and right index of myocardial
performance (RIMP) were significantly increased in children with ASD compared with control subjects while tricuspid annular plane systolic excursion (TAPSE) was significantly decreased. Six months after closure, RA, and
RV dimensions significantly decreased and RV function improved (RIMP decreased and TAPSE increased). Gal-3
oncentration significantly decreased 1 month after ASD closure, but it did not reach normal range compared with
control subjects. A positive correlation between Gal-3 and age at closure, RA area, RV dimensions, and RIMP was
observed. A positive correlation was observed between the decrease in Gal-3 concentration and the decrease in
RA area and RV dimensions 1 month after ASD closure. A significant negative correlation was observed between
TAPSE and Gal-3 concentration before and after intervention. Conclusions: Percutaneous ASD closure can
improve right-sided indices and decrease serum Gal-3 concentration. Gal-3 can be used as a sensitive biomarker
of right heart remodeling, with a decrease in Gal-3 concentration suggesting reversal of maladaptive remodeling. 相似文献
63.
Role of endoscopic ultrasound and cyst fluid tumor markers in diagnosis of pancreatic cystic lesions
Hussein Hassan Okasha Abeer Abdellatef Shaimaa Elkholy Mohamad-Sherif Mogawer Ayman Yosry Magdy Elserafy Eman Medhat Hanaa Khalaf Magdy Fouad Tamer Elbaz Ahmed Ramadan Mervat E Behiry Kerolis Y William Ghada Habib Mona Kaddah Haitham Abdel-Hamid Amr Abou-Elmagd Ahmed Galal Wael A Abbas Ahmed Youssef Altonbary Mahmoud El-Ansary Aml E Abdou Hani Haggag Tarek Ali Abdellah Mohamed A Elfeki Heba Ahmed Faheem Hani M Khattab Mervat El-Ansary Safia Beshir Mohamed El-Nady 《World journal of gastrointestinal endoscopy》2022,14(6):402-415
64.
Discovery of Novel Peptidomimetics as Irreversible CHIKV NsP2 Protease Inhibitors Using Quantum Mechanical‐Based Ligand Descriptors 下载免费PDF全文
Eman M. El‐labbad Mohammed A. H. Ismail Dalal A. Abou Ei Ella Marawan Ahmed Feng Wang Khaled H. Barakat Khaled A. M. Abouzid 《Chemical biology & drug design》2015,86(6):1518-1527
Chikungunya virus (CHIKV) is a mosquito‐borne alphavirus. Recent outbreaks of CHIKV infections have been reported in Asia, Africa, and Europe. The symptoms of CHIKV infection include fever, headache, nausea, vomiting, myalgia, rash, and chronic persistent arthralgia. To date, no vaccines or selective antiviral drugs against this important emerging virus have been reported. In this study, the design, synthesis, and antiviral activity screening of new topographical peptidomimetics revealed three potential prototype agents 3a , 4b, and 5d showing 93–100% maximum inhibition of CHIKV replication in cell‐based assay having EC90 of 8.76–9.57 μg/mL. Intensive molecular modeling studies including covalent docking, lowest unoccupied molecular orbital energies, and the atomic condensed Fukui functions calculations strongly suggested the covalent binding of peptidomimetics 3a , 4b, and 5d to CHIKV nsP2 protease leading to permanent enzyme inactivation via Michael adduct formation between α/β‐unsaturated ketone functionality in our designed peptidomimetics and active site catalytic cysteine1013. Furthermore, small molecular weight peptidomimetics 3a and 4b satisfied the Lipinski rule of five for drug‐likeness and showed promising intestinal absorption and aqueous solubility via computational admet studies making them promising hits for further optimization. 相似文献
65.
Fatma Abdellah Mohamed Sawsan Mahmoud El-Bana Eman Abd-Elaziz Mohamed Nagat Farouk Abolwafa 《Journal of neonatal nursing : JNN》2019,25(6):285-292
BackgroundNewborn infants have an increased sensitivity to pain and are more reactive to pain than older children and adults. Nurses play a crucial role in assessing pain, implementing and evaluating interventions to minimize neonatal pain using available resources especially nonpharmacologic techniques.Aim of the studyto develop and apply an educational program on pediatric nurses regarding selected nonpharmacologic techniques to relieve pain in neonates.Research designA pre/post quasi-experimental research design was utilized in the present study. The study was carried out at Minia University for Obstetric and Pediatric and General Hospitals at neonatal care units. A convenient sample of 41 nurses was included in this study. Educational program for nurses was done through using the following data collection tools 1) Pre-designed questionnaire sheet, 2) Observation checklists sheet and 3) Educational and training program.ResultsIt was revealed that there was an obvious increase in the total mean scores of knowledge and practice in post and follow up program phase compared with pretest phase, with a very highly significant difference (p < 0.001).ConclusionThe education program had a significant impact on pediatric nurses' knowledge and practices regarding selected nonpharmacologic techniques to relieve pain in neonates.RecommendationsA continuous training and educational program should be planned and offered on regular basis for nurses regarding nonpharmacologic techniques to relieve pain in neonates. 相似文献
66.
The correlation of CD4+ T-lymphocyte count and the distribution of pathogenic or opportunistic microbial infection most commonly found in HIV positive individuals differ from one area to the other. The present study reports such findings in 67 HIV positive Bahraini patients in the period May 1997 to Nov. 1998. CD4+ T-lymphocyte count was measured using flow cytometry. Bacterial and fungal cultures were performed. Serological diagnosis was performed when indicated. Viral study was done serologically. The distribution of CD4+ T-lymphocyte count in the studied group was: 21 patients (31.3%) less than 100 cells/microl, 5 patients (7.5%) 100-200 cells/microl, 25 patients (37.3%) 201-500 cells/microl and 16 patients (23.9%) with count more than 500 cells/microl. Among patients with low CD4 count (less than 100 cells/microl) (n=21), microbial infections varied from fungal infections 66%, bacterial infections 57% and viral infections 4.8%. Bacterial infections included Salmonellosis (14.3%), Staphylococcus epidermidis (14.3%), Pseudomonas aeruginosa (9.5%), H. influenzae (9.5%), Legionellosis (4.8%) and E. coli (4.8%). Fungal infection included Candida albicans (52.4%), Pneumocystis carinii (9.5%), Cryptococcus neoformans (4.8%). Viral infection included H. simplex to (4.8%). Fungal infections were the highest common infection in thus study. The most common microbial infection was Candida albicans. P. carinii and Cryptococcus neoformans were less common than found in other studies world wide. 相似文献
67.
Eman M. Hassan Dalia A. Omran Mohamad L. El Beshlawey Mahmoud Abdo Ahmad El Askary 《Gastroenterologia y hepatologia》2014
Background
Gastroesophageal varices are present in approximately 50% of patients with liver cirrhosis. The aim of this study was to evaluate liver stiffness measurement (LSM), Fib-4, Forns Index and Lok Score as noninvasive predictors of esophageal varices (EV).Methods
This prospective study included 65 patients with HCV-related liver cirrhosis. All patients underwent routine laboratory tests, transient elastograhy (TE) and esophagogastroduodenoscopy. FIB-4, Forns Index and Lok Score were calculated. The diagnostic performances of these methods were assessed using sensitivity, specificity, positive predictive value, negative predictive value, accuracy and receiver operating characteristic curves.Results
All predictors (LSM, FIB-4, Forns Index and Lok Score) demonstrated statistically significant correlation with the presence and the grade of EV. TE could diagnose EV at a cutoff value of 18.2 kPa. Fib-4, Forns Index, and Lok Score could diagnose EV at cutoff values of 2.8, 6.61 and 0.63, respectively. For prediction of large varices (grade 2, 3), LSM showed the highest accuracy (80%) with a cutoff of 22.4 kPa and AUROC of 0.801. Its sensitivity was 84%, specificity 72%, PPV 84% and NPV 72%. The diagnostic accuracies of FIB-4, Forns Index and Lok Score were 70%, 70% and76%, respectively, at cutoffs of 3.3, 6.9 and 0.7, respectively. For diagnosis of large esophageal varices, adding TE to each of the other diagnostic indices (serum fibrosis scores) increased their sensitivities with little decrease in their specificities. Moreover, this combination decreased the LR− in all tests.Conclusion
Noninvasive predictors can restrict endoscopic screening. This is very important as non invasiveness is now a major goal in hepatology. 相似文献68.
69.
Khedr Eman M. El Fetoh Noha Abo Gamal Rania M. Elzohri Mona H. Azoz Nashwa Mostafa A. Furst Daniel E. 《Clinical rheumatology》2020,39(5):1551-1559
Clinical Rheumatology - To investigate cognitive dysfunction in adult patients with systemic sclerosis (SSc) who had no known clinical neurological manifestations and to relate it with other... 相似文献
70.
Abdelbasset Walid Kamal Alrawaili Saud M. Nambi Gopal Yassen Eman Moawd Samah A. Ahmed Ahmed S. 《Clinical rheumatology》2020,39(10):3091-3097
Clinical Rheumatology - Diabetic neuropathy (DN) is a common and serious complication of diabetes. DN patients are suffering from anxiety, depression, and impairment of functional capacity. Rare... 相似文献