全文获取类型
收费全文 | 2820篇 |
免费 | 204篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 29篇 |
儿科学 | 72篇 |
妇产科学 | 58篇 |
基础医学 | 296篇 |
口腔科学 | 116篇 |
临床医学 | 309篇 |
内科学 | 694篇 |
皮肤病学 | 88篇 |
神经病学 | 242篇 |
特种医学 | 107篇 |
外科学 | 256篇 |
综合类 | 11篇 |
一般理论 | 1篇 |
预防医学 | 225篇 |
眼科学 | 69篇 |
药学 | 176篇 |
中国医学 | 4篇 |
肿瘤学 | 284篇 |
出版年
2024年 | 4篇 |
2023年 | 27篇 |
2022年 | 49篇 |
2021年 | 133篇 |
2020年 | 93篇 |
2019年 | 106篇 |
2018年 | 130篇 |
2017年 | 78篇 |
2016年 | 91篇 |
2015年 | 105篇 |
2014年 | 117篇 |
2013年 | 159篇 |
2012年 | 240篇 |
2011年 | 266篇 |
2010年 | 132篇 |
2009年 | 113篇 |
2008年 | 203篇 |
2007年 | 209篇 |
2006年 | 170篇 |
2005年 | 154篇 |
2004年 | 127篇 |
2003年 | 120篇 |
2002年 | 115篇 |
2001年 | 12篇 |
2000年 | 9篇 |
1999年 | 11篇 |
1998年 | 14篇 |
1997年 | 12篇 |
1996年 | 14篇 |
1995年 | 6篇 |
1994年 | 8篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1984年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有3037条查询结果,搜索用时 31 毫秒
31.
32.
Hospital care following emergency admission: a critical incident case study of the experiences of patients with advanced lung cancer and Chronic Obstructive Pulmonary Disease
下载免费PDF全文
![点击此处可从《Journal of clinical nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
33.
34.
Teresa Fu M.D. Elizabeth Keiser M.D. Eleni Linos M.D. Dr.P.H. Robert M. Rotatori B.A. Kristin Sainani Ph.D. Bharathi Lingala M.D. Alfred T. Lane M.D. Lynda Schneider M.D. Jean Y. Tang M.D. Ph.D. 《Pediatric dermatology》2014,31(1):21-26
The relationship between food and environmental allergens in contributing to eczema risk is unclear on a multiethnic population level. Our purpose was to determine whether sensitization to specific dietary and environmental allergens as measured according to higher specific immunoglobulin E (IgE) levels is associated with eczema risk in children. National Health and Nutrition Examination Survey participants ages 1 to 17 years were asked whether they had ever received a diagnosis of eczema from a physician (n = 538). Total and specific serum IgE levels for four dietary allergens (egg, cow's milk, peanut, and shrimp) and five environmental allergens (dust mite, cat, dog, Aspergillus, and Alternaria) were measured. Logistic regression was used to examine the association between eczema and IgE levels. In the United States, 10.4 million children (15.6%) have a history of eczema. Eczema was more common in black children (p < 0.001) and in children from families with higher income and education (p = 0.01). The median total IgE levels were higher in children with a history of eczema than in those without (66.4 vs 50.6 kU/L, p = 0.004). In multivariate analysis adjusted for age, race, sex, family income, household education, and physician‐diagnosed asthma, eczema was significantly associated with sensitization to cat dander (odds ratio [OR] = 1.2, 95% confidence interval [CI] 1.05, 1.4, p = 0.009) and dog dander (OR = 1.5, 95% CI, 1.2, 1.7, p < 0.001). After correction for multiple comparisons, only sensitization to dog dander remained significant. U.S. children with eczema are most likely to be sensitized to dog dander. Future prospective studies should further explore this relationship. 相似文献
35.
Ioannis Tsitouridis PhD MD Charalampos Maskalidis MD Despoina Panagiotidou MD Eleni P Kariki MScHI MScHCM MD 《Journal of ultrasound in medicine》2014,33(10):1855-1864
We present the sonographic and magnetic resonance imaging findings of Leydig cell tumors in a series of patients, along with a brief review of the literature. We evaluated the sonographic features of 11 cases of Leydig cell tumors, including echogenicity, size, margins, and patterns of vascularity. The magnetic resonance imaging characteristics of 9 patients were also assessed, with special attention to the appearance of the tumors on T2-weighted imaging and postcontrast T1-weighted imaging. Seven tumors were hypoechoic, and 4 were almost isoechoic. Ten patients showed various patterns of hypervascularity in the tumors, combined in some cases with feeding vessels. One case presented with a single feeding vessel. The tumors showed homogeneous or heterogeneous low signal intensity on T2-weighted imaging and marked enhancement on postcontrast T1-weighted imaging. The small size of these tumors, the various patterns of vascularity on color and power Doppler sonography, and the marked enhancement on postcontrast T1-weighted imaging are considered valuable but generally nonspecific for identification of these tumors. 相似文献
36.
Theodoros N. Sergentanis Antonios G. Antoniadis Helen J. Gogas Constantine N. Antonopoulos Hans-Olov Adami Anders Ekbom Eleni Th. Petridou 《European journal of cancer (Oxford, England : 1990)》2013,49(3):642-657
Although obesity is an established risk factor for several cancer types, its possible role in the aetiology of malignant melanoma remains unclear. This meta-analysis aims to examine the association between obesity and melanoma risk, exploring any tentative gender-specific associations. After the identification of eligible studies, we estimated pooled effect estimates (odds ratios and relative risks), undertook a meta-regression analysis and analysed separately risk of malignant melanoma among males and females in relation to body mass index (BMI) and body surface area (BSA). Out of the 21 eligible articles, 11 used a case–control design encompassing 4460 cases/6342 controls; 10 used a cohort design whose total size comprised 7895 incident cases/6,368,671 subjects. Among males, the pooled effect estimate was 1.31 (95% confidence interval (CI): 1.18–1.45) for overweight and 1.31 (95% CI: 1.19–1.44) for obese. Meta-regression revealed no significant slope, most probably due to the underlying plateau in effect estimates. Among females, no significant association was documented; the pooled effect estimate for overweight and obese subjects was 0.98 (95% CI: 0.92–1.05) and 0.99 (95% CI: 0.83–1.18), respectively. Noticeably, there was evidence for confounding between sunlight exposure and obesity in females. All results were reproducible upon analyses on BSA. In conclusion, overweight and obesity are associated with increased risk of malignant melanoma among males. Meticulous assessment of sunlight exposure is needed especially in women, since self limited public sun exposure may be prevalent among overweight or obese females. Higher-order associations between BMI and melanoma risk should be addressed and examined by the future studies. 相似文献
37.
38.
Robert Miller Eleni Ieremia Jeremy Birch James Chan 《Journal of cutaneous pathology》2018,45(9):696-700
Poroid hidradenoma (PH) is a rare benign neoplasm of the skin appendages. There are currently no guidelines for its management, and little information available regarding the natural history, treatment options, or outcomes. Systematic literature review identified 19 cases of isolated PH. Mean age at presentation was 54 years. Male to female ratio was 3:1, and the majority of cases were in the head and neck region. One‐third of lesions were painful or tender. Sizes varied from 0.11 × 0.9 × 0.2 cm (digit) to 6 cm (presternal region). Twelve cases were treated by surgical excision, while the remainder were biopsy specimens. Follow‐up was reported in five cases, with a median follow‐up of 1 year. No cases of local invasion or spread have been reported, although there was one case of possible recurrence identified 8 years after surgical excision. The presented case is the first to identify a PH on the hand, represents the smallest lesion to date, and was successfully treated by excision. We suggest that PHs be treated by excision and followed up for 6 to 12 months. Given one case of potential (but unconfirmed) recurrence, and no report of malignant transformation, we suggest that narrow margins may be appropriate. 相似文献
39.
Maria Kostaki Argyro D. Manona Irene Stavraka Penelope Korkolopoulou Georgia Levidou Eleni‐Andriana Trigka Eleftheria Christofidou Grigorios Champsas Alexandros J. Stratigos Andreas Katsambas Othon Papadopoulos Christina Piperi Athanasios G. Papavassiliou 《Experimental dermatology》2014,23(5):332-338
Epigenetic mechanisms participate in melanoma development and progression. The effect of histone modifications and their catalysing enzymes over euchromatic promoter DNA methylation in melanoma remains unclear. This study investigated the potential association of p16INK4A promoter methylation with histone methyltransferase SETDB1 expression in Greek patients with sporadic melanoma and their correlation with clinicopathological characteristics. Promoter methylation was detected by methylation‐specific PCR in 100 peripheral blood samples and 58 melanoma tissues from the same patients. Cell proliferation (Ki‐67 index), p16INK4A and SETDB1 expression were evaluated by immunohistochemistry. High‐frequency promoter methylation (25.86%) was observed in tissue samples and correlated with increased cell proliferation (P = 0.0514). p16INK4A promoter methylation was higher in vertical growth‐phase (60%) melanomas than in radial (40%, P = 0.063) and those displaying epidermal involvement (P = 0.046). Importantly, p16INK4A methylation correlated with increased melanoma thickness according to Breslow index (P = 0.0495) and marginally with increased Clark level (I/II vs III/IV/V, P = 0.070). Low (1–30%) p16INK4A expression was detected at the majority (19 of 54) of melanoma cases (35.19%), being marginally correlated with tumor lymphocytic infiltration (P = 0.078). SETDB1 nuclear immunoreactivity was observed in 47 of 57 (82.46%) cases, whereas 27 of 57 (47.37%) showed cytoplasmic immunoexpression. Cytoplasmic SETDB1 expression correlated with higher frequency of p16INK4A methylation and p16INK4A expression (P = 0.033, P = 0.011, respectively). Increased nuclear SETDB1 levels were associated with higher mitotic count (0–5/mm2 vs >5/mm2, P = 0.0869), advanced Clark level (III‐V, P = 0.0380), epidermal involvement (P = 0.0331) and the non‐chronic sun exposure‐associated melanoma type (P = 0.0664). Our data demonstrate for the first time the association of histone methyltransferase SETDB1 with frequent methylation of the euchromatic p16INK4A promoter and several prognostic parameters in melanomas. 相似文献
40.
Kostas Fasoulas Athanasios Beltsis Taxiarchis Katsinelos Eleni Dimou Mary Arvaniti Anna Charsoula Victor Gourvas Stefanos Atmatzidis Grigoris Chatzimavroudis Panagiotis Katsinelos 《Saudi Journal Of Gastroenterology》2012,18(2):146-148
Mesenteric panniculitis (MP) is a rare inflammatory and fibrotic disease of the mesentery of unknown etiology. It has various clinical and radiological manifestations, posing a diagnostic challenge for clinicians. Its diagnosis is indicated via radiologic imaging and is usually confirmed via peritoneal biopsies. We describe a case of a patient with histopathologically proven MP, in which steroid dependence was successfully managed with colchicine. 相似文献