全文获取类型
收费全文 | 519篇 |
免费 | 103篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 11篇 |
妇产科学 | 5篇 |
基础医学 | 36篇 |
口腔科学 | 9篇 |
临床医学 | 78篇 |
内科学 | 138篇 |
神经病学 | 45篇 |
特种医学 | 193篇 |
外科学 | 52篇 |
综合类 | 11篇 |
预防医学 | 14篇 |
眼科学 | 4篇 |
药学 | 12篇 |
肿瘤学 | 17篇 |
出版年
2023年 | 11篇 |
2021年 | 6篇 |
2020年 | 4篇 |
2018年 | 25篇 |
2017年 | 10篇 |
2016年 | 18篇 |
2015年 | 19篇 |
2014年 | 38篇 |
2013年 | 44篇 |
2012年 | 3篇 |
2011年 | 13篇 |
2010年 | 31篇 |
2009年 | 42篇 |
2008年 | 19篇 |
2007年 | 11篇 |
2006年 | 10篇 |
2005年 | 7篇 |
2004年 | 11篇 |
2003年 | 5篇 |
2002年 | 9篇 |
2001年 | 8篇 |
2000年 | 8篇 |
1999年 | 8篇 |
1998年 | 22篇 |
1997年 | 23篇 |
1996年 | 16篇 |
1995年 | 13篇 |
1994年 | 11篇 |
1993年 | 17篇 |
1992年 | 4篇 |
1991年 | 5篇 |
1990年 | 8篇 |
1989年 | 24篇 |
1988年 | 17篇 |
1987年 | 16篇 |
1986年 | 8篇 |
1985年 | 13篇 |
1984年 | 7篇 |
1983年 | 4篇 |
1982年 | 10篇 |
1981年 | 7篇 |
1980年 | 9篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1977年 | 6篇 |
1976年 | 8篇 |
1975年 | 4篇 |
1971年 | 2篇 |
1961年 | 1篇 |
1929年 | 1篇 |
排序方式: 共有627条查询结果,搜索用时 15 毫秒
41.
Noncardiogenic pulmonary edema is a recognized but uncommon manifestation of type 2 decompression sickness. It typically occurs within 6 hours of a dive. Because the adult respiratory distress syndrome in this setting is believed to be due to microbubbles in the pulmonary vasculature, recompression in a hyperbaric chamber has been recommended as a form of therapy. A patient developed noncardiogenic pulmonary edema following a seawater dive to 75 feet. There was complete radiologic and clinical resolution within 5 hours of hyperbaric therapy. 相似文献
42.
Halbach VV; Higashida RT; Hieshima GB; Reicher M; Norman D; Newton TH 《Radiology》1987,163(2):437-442
Thirty symptomatic indirect carotid cavernous fistulas were treated between 1978 and 1986 with a variety of treatment modalities. Combined carotid artery and jugular vein compression resulted in a complete cure in seven of 23 patients (30%) and improvement in one additional patient. There were no complications from this treatment, which is performed by the patient on an outpatient basis. Patients in whom carotid jugular compression therapy failed or who demonstrated cortical venous drainage or visual decline were treated with intravascular embolization. Embolization resulted in complete cure in 17 of 22 (77%) and improvement in four of 22 (18%). One patient required surgical excision of the involved dura after embolization to achieve complete cure. There was one permanent complication (stroke), which resulted in mild weakness caused by clot formation on a catheter. 相似文献
43.
Early and late forms of cyclosporine nephrotoxicity: studies in cardiac transplant recipients 总被引:3,自引:0,他引:3
A Greenberg J W Egel M E Thompson R L Hardesty B P Griffith H T Bahnson R L Bernstein A Hastillo M L Hess J B Puschett 《American journal of kidney diseases》1987,9(1):12-22
To characterize the two forms of cyclosporine nephrotoxicity, we examined renal function in the immediate and late postoperative periods after cardiac transplantation. Moderate azotemia occurred during the first postoperative week in 58% of 43 cyclosporine-treated recipients, but in only 34% of 41 azathioprine-treated recipients, and 4% of 25 patients undergoing cardiopulmonary bypass for nontransplant surgery (both P less than .01 v cyclosporine). Acute renal failure developed in an additional 12% of the cyclosporine-treated group. Late postoperative renal dysfunction also occurred with a high prevalence. Life-table analysis indicated that at 6 months 55%, at 12 months 17%, at 24 months 4%, and at 36 months no cyclosporine-treated recipients retained normal renal function. Three renal biopsies performed in subjects with late nephrotoxicity demonstrated prominent interstitial fibrosis. Although one patient subsequently required chronic dialysis, reduction of cyclosporine dosage from a mean of 5.3 +/- 0.7 mg/kg/d to a mean of 2.3 +/- 0.3 mg/kg/d 9 to 21 months after transplantation with concurrent initiation of azathioprine therapy to prevent rejection led to an improvement of renal function in the five patients so treated. These data indicate that there are two distinct forms of cyclosporine nephrotoxicity. Although both occur with high prevalence, the early form does not appear to be a specific risk factor for the late form. 相似文献
44.
Isolation and characterization of murine cell surface components. I. Purification of milligram quantities of Thy-1.1 总被引:1,自引:0,他引:1
下载免费PDF全文
![点击此处可从《The Journal of experimental medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
The Thy-l.1 molecule was isolated from the BW5147 murine lymphoblastoid cell line. The initial step in purification was the preparation of a crude plasma membrane fraction followed by acetone precipitation. The acetone pellet was solubilized using deoxycholate (DOC) and Thy-1.1 was purified by use of a Lens culinaris lectin affinity column and an AcA-34 gel filtration column. The purified glycoprotein with Thy-1.1 activity had a mol wt of approximately 25,000 daltons. The isolation of this molecule was effected by detecting Thy-I activity utilizing rabbit anti- mouse brain serum tested on rat thymocytes. Congenic anti-Thy-l.1 serum was ineffective in detecting Thy-l.1 after DOC solubilization. An antiserum prepared in rabbits to the purified Thy-1.1 was found to be cytotoxic to mouse and rat thymocytes. The cytotoxic activity of this antisera could be completely absorbed with AKR/Jax brain and thymus but was not absorbed by liver. In addition, AKR/Jax thymocytes totally absorbed all cytotoxic activity of the rabbit anti-purified Thy-1 serum for BW5147 cells suggesting that the cell line shares identical specificities with normal thymocytes. The purified Thy-1.1 molecule was able to totally absorb the cytotoxic activity of mouse congenic anti-Thy-1. These studies serve as a model for the isolation of other murine lymphoid cell surface components in quantities for detailed structural and functional analysis. 相似文献
45.
Thomas Falvo DO Lance Grove RT EMT-P Ruth Stachura RN David Vega MD Rose Stike MEd Melissa Schlenker BS William Zirkin MD 《Academic emergency medicine》2007,14(4):332-337
Objectives: Boarding admitted patients in emergency department (ED) treatment beds has been recognized as a major cause of ED crowding and ambulance diversions. When process delays impede the transfer of admitted patients from the ED to inpatient units, the department's capacity to accept new arrivals and to generate revenue from additional patient services is restricted. The objective of this study was to determine the amount of functional ED treatment capacity that was used to board inpatients during 12 months of operations at a community hospital and to estimate the value of that lost treatment capacity.
Methods: Historical data from 62,588 patient visits to the ED of a 450-bed nonprofit community teaching hospital in south central Pennsylvania between July 2004 and June 2005 were used to determine the amount of treatment bed occupancy lost to inpatient holding and the revenue potential of utilizing that blocked production capacity for additional patient visits.
Results: Transferring admitted patients from the ED to an inpatient unit within 120 minutes would have increased the functional treatment capacity of the ED by 10,397 hours during the 12 months of this study. By reducing admission process delays, the hospital could potentially have accommodated another 3,175 patient encounters in its existing treatment spaces. Providing emergency services to new patients in ED beds formerly used to board inpatients could have generated $3,960,264 in additional net revenue for the hospital.
Conclusions: Significantly higher operational revenues could be generated by reducing output delays that restrict optimal utilization of existing ED treatment capacity. 相似文献
Methods: Historical data from 62,588 patient visits to the ED of a 450-bed nonprofit community teaching hospital in south central Pennsylvania between July 2004 and June 2005 were used to determine the amount of treatment bed occupancy lost to inpatient holding and the revenue potential of utilizing that blocked production capacity for additional patient visits.
Results: Transferring admitted patients from the ED to an inpatient unit within 120 minutes would have increased the functional treatment capacity of the ED by 10,397 hours during the 12 months of this study. By reducing admission process delays, the hospital could potentially have accommodated another 3,175 patient encounters in its existing treatment spaces. Providing emergency services to new patients in ED beds formerly used to board inpatients could have generated $3,960,264 in additional net revenue for the hospital.
Conclusions: Significantly higher operational revenues could be generated by reducing output delays that restrict optimal utilization of existing ED treatment capacity. 相似文献
46.
M. TROSSAËRT V. REGNAULT† M. SIGAUD P. BOISSEAU‡ E. FRESSINAUD T. LECOMPTE† 《Journal of thrombosis and haemostasis》2008,6(3):486-493
Summary. Introduction: In some patients with mild hemophilia A, there are discrepancies between 1-stage (1-st) and 2-stage (2-st) factor VIII (FVIII) clotting assays, and also chromogenic assays for FVIII activity (FVIII:C). We examined whether thrombography could provide a better evaluation of the hemostatic status of these patients. Methods: Two families with such discrepancies and markedly contrasting clinical histories were studied. Family X had no serious bleedings, in contrast to family Y. Sixty-one moderate/mild hemophiliacs without discrepancy and 15 healthy subjects served as controls. Calibrated automated thrombography was performed with platelet-rich plasma after one freeze-thawing cycle and low tissue factor concentration. Results: The chromogenic FVIII:C levels were higher (0.90 ± 0.15 and 0.47 ± 0.13 IU mL−1 ) than the 1-st clotting ones (0.14 ± 0.05 and 0.10 ± 0.05 IU mL−1 ) in family X and Y, respectively ( P < 0.001). Mean endogenous thrombin potential (ETP) was 1579 ± 359 n m min−1 and 1060 ± 450 for healthy controls and hemophilic controls, respectively. For members of family X, the ETP values were 1188, 1317 and 2277 n m min−1 , whereas for those of family Y they ranged from 447 to 1122 n m min−1 . Two novel missense point mutations were evidenced: p.Ile369Thr in family X and p.Phe2127Ser in family Y. In family X, we postulate that the mutation is responsible for a delayed but non-deleterious FVIII activation. Conclusions: Our results suggest that the hemostatic phenotype assessed by thrombography may be clinically relevant in moderate/mild hemophilic patients with discrepant FVIII:C results. 相似文献
47.
48.
Radiography on wheels arrives to nursing homes – an economic assessment of a new health care technology in southern Sweden
下载免费PDF全文
![点击此处可从《Journal of evaluation in clinical practice》网站下载免费的PDF全文](/ch/ext_images/free.gif)
49.
Gloria Maccabelli MD Anna Pichiecchio MD Andrea Guala MD Michela Ponzio PhD Fulvia Palesi PhD Diego Maranzana RT Guy Umberto Poloni PhD Stefano Bastianello MD PhD Cesare Danesino MD PhD 《Movement disorders》2010,25(15):2670-2674
No brain abnormalities are usually detected on conventional magnetic resonance imaging (MRI) in benign hereditary chorea (BHC); there are currently no studies with advanced techniques in literature. We investigated whether conventional and advanced MRI techniques could depict regional brain abnormalities in two familial BHC patients and 24 healthy controls. No brain abnormalities on conventional scans were detectable; also, no significant differences in fractional anisotropy of the basal nuclei were observed. Volumetric analysis showed a decreased volume of the striatum bilaterally compared with controls, whereas spectroscopy demonstrated a significant increased myoinositol/creatine ratio bilaterally, a reduction of choline/creatine ratio bilaterally, and of N‐acetyl‐aspartate/creatine in the right putamen. With the limits of the small sample size in the patient group, these data show that, despite the absence of macroscopic changes on conventional MRI, volumetric and metabolic abnormalities are present in the basal nuclei of BHC patients. © 2010 Movement Disorder Society. 相似文献
50.
Giacomo Pavesi MD Oriela Rustemi MD Silvia Berlucchi MD Anna Chiara Frigo MD Valerio Gerunda RT Renato Scienza MD 《Surgical neurology》2009,72(6):662-667