全文获取类型
收费全文 | 200篇 |
免费 | 18篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 3篇 |
妇产科学 | 4篇 |
基础医学 | 16篇 |
口腔科学 | 6篇 |
临床医学 | 13篇 |
内科学 | 63篇 |
皮肤病学 | 2篇 |
神经病学 | 44篇 |
特种医学 | 6篇 |
外科学 | 32篇 |
预防医学 | 13篇 |
眼科学 | 2篇 |
药学 | 10篇 |
肿瘤学 | 7篇 |
出版年
2023年 | 3篇 |
2022年 | 9篇 |
2021年 | 15篇 |
2020年 | 15篇 |
2019年 | 17篇 |
2018年 | 14篇 |
2017年 | 18篇 |
2016年 | 5篇 |
2015年 | 6篇 |
2014年 | 15篇 |
2013年 | 13篇 |
2012年 | 9篇 |
2011年 | 15篇 |
2010年 | 6篇 |
2009年 | 6篇 |
2008年 | 7篇 |
2007年 | 6篇 |
2006年 | 7篇 |
2005年 | 9篇 |
2004年 | 15篇 |
2003年 | 6篇 |
2002年 | 3篇 |
2001年 | 1篇 |
1996年 | 1篇 |
排序方式: 共有221条查询结果,搜索用时 31 毫秒
41.
Physical exercise offers numerous health-related benefits to individuals with cancer. Epidemiologic research has primarily been concerned with conventional exercise training that aligns with the recommendations of 150 min of moderate to vigorous physical activity per week. These recommendations are safe and effective at improving physical and psychosocial outcomes. Given the extensive evidence for generalized physical activity, researchers have begun to explore novel training regimens that may provide additional health benefits and/or improved adherence. Specifically, exercise at higher intensities may offer more or different benefits than conventional training approaches with potentially profound effects on the tumor microenvironment. This commentary focuses on the physiological effects of high-intensity interval training, also known as “HIIT,” and its potential antineoplastic properties. 相似文献
42.
43.
Andrew E. Leake Michael A. Segal Rabih A. Chaer Mohammad H. Eslami Georges Al-Khoury Michel S. Makaroun Efthymios D. Avgerinos 《Journal of vascular surgery》2017,65(1):246-256.e2
Objective
Endovascular popliteal artery aneurysm repair (EPAR) is increasingly used over open surgical repair (OPAR). The purpose of this study was to analyze the available literature on their comparative outcomes.Methods
The PubMed and Embase databases were searched to identify studies comparing OPAR and EPAR. Studies with only one treatment and fewer than five patients were excluded. Demographics and outcomes were collected. Bias risk was assessed using a modified version of the Newcastle-Ottawa Scale. Results were computed from random-effects meta-analyses using the DerSimonian-Laird algorithm.Results
A total of 14 studies were identified encompassing 4880 popliteal artery aneurysm repairs (OPAR, 3915; EPAR, 1210) during the last decade. OPAR patients were younger (standard mean difference, ?0.798 [?0.798 to ?1.108]; P < .001) and more likely to have worse tibial runoff (odds ratio [OR], 1.949 (1.15-3.31); P = .013) than EPAR patients. OPAR had higher odds of wound complications (OR, 5.182 [2.191-12.256]; P < .001) and lower odds of thrombotic complications (OR, 0.362 [0.155-0.848]; P < .001). OPAR had longer length of stay (standardized mean difference, 2.158 [1.225-3.090]; P < .001) and fewer reinterventions (OR, 0.275 [0.166-0.454]; P < .001). Primary patency was better for OPAR at 1 year and 3 years (relative risk, 0.607 [P = .01] and 0.580 [P = .006], respectively). There was no difference in secondary patency at 1 year and 3 years (0.770 [P = .458] and 0.642 [P = .073], respectively).Conclusions
EPAR has a lower wound complication rate and shorter length of hospital stay compared with OPAR. This comes at the cost of inferior primary patency but not secondary patency out to 3 years. Studies reporting long-term outcomes are lacking and necessary. 相似文献44.
45.
Efthymios Iliopoulos Natasha Morrissey Seok Cho Arshad Khaleel 《Journal of orthopaedic science》2017,22(4):783-786
Aim
The use of circular frame is widely accepted. This is an outcome review on use of circular Ilizarov frame in elderly patients.Materials & methods
Data from all patients treated with an Ilizarov circular frame between January 2002 and December 2014, who were 65 years of age or over at surgery was collected. Seventy Ilizarov circular frames were applied during this period in our unit at a mean age of 71.2 years. Clinical, radiological and quality of life questionnaire (SF-12) data were gathered. Mortality, complication and revision data were also collected.Results
Indications of application of Ilizarov frame were fractures (53%), non-unions (19%), deformity correction (7%) and ankle fusions (21%). Mean period of time in the frame was 184.4 ± 84.2 days. Mortality and complication rates were low (5–7%) at a mean follow-up 4.2 years. There was no case of septic arthritis or newly induced deep infection. Physical and Mental components of SF-12 questionnaire returned to normal for that age group. There was no difference between the subgroups (tibia plateau fractures, pilon fractures, ankle fusions, non-unions, deformity correction and miscellaneous trauma) concerning the physical and mental subjective (PCS and MCS SF-12 component) outcomes (p > 0.05).Conclusions
Ilizarov circular frame as a definitive treatment of many kinds of trauma and orthopaedic conditions can be safely and reliably used in the elderly with good quality of life results. 相似文献46.
47.
Paraoxonase 1 gene polymorphisms in patients with osteonecrosis of the femoral head with and without cerebral white matter lesions. 总被引:2,自引:0,他引:2
Georgios M Hadjigeorgiou Konstantinos Malizos Efthimios Dardiotis Konstantinos Aggelakis Maria Dardioti Aristidis Zibis Apostolos Dimitroulias Nikolaos Scarmeas Aspasia Tsezou Apostolos Karantanas 《Journal of orthopaedic research》2007,25(8):1087-1093
Cerebral white matter lesions (WML) are present in more than 50% of patients with osteonecrosis of the femoral head (ONFH). Paraoxonase 1 (PON1) gene product is a detoxifying and pesticide metabolizing enzyme. Genetic variants of the PON1 gene have been found to influence the occurrence and progression of WML. We examined whether two PON1 polymorphisms (M55L and R192Q) are associated with ONFH and influence the occurrence of WML. We studied 104 patients with ONFH and 113 healthy age- and sex-matched subjects. We used logistic regression models to examine associations and survival analyses (Cox proportional hazards models) to examine possible influence of alleles on age at onset of ONFH. We found no association of PON1 M55L alleles and genotypes with ONFH. The distribution of PON1 Q192R alleles (p = 0.001) and genotypes (QQ vs. QR/RR) (p = 0.004) were statistically different between controls and patients. Patients with QQ genotype had six times higher risk for WML at brain MRI (adjusted OR 5.95; 95% CI 1.30-27.03; p = 0.02). In Cox models, there was a significant association of allele Q with risk for ONFH indicating a possible dose effect (HR = 1.43; 95%CI = 1.04-1.97; p for trend = 0.03). We conclude that individuals with PON1 192QQ genotype may have increased risk for ONFH and WMLeOn. 相似文献
48.
49.
Emily Iacovou Petros V. Vlastarakos George Papacharalampous Efthymios Kyrodimos Thomas P. Nikolopoulos 《European archives of oto-rhino-laryngology》2013,270(11):2803-2813
The aim of this study was to compare the hearing results and graft integration rates in patients undergoing myringoplasty for the reconstruction of the tympanic membrane, with the use of either cartilage or temporalis muscle fascia (TMF). A systematic literature review in Medline and other database sources up to February 2012 was carried out, and the pooled data were meta-analyzed. Twelve studies were systematically analyzed. One represented level I, one level II and ten level III evidence. The total number of treated patients was 1,286. Cartilage reconstruction was used in 536, TMF in 750 cases. Two level III studies showed a significant difference between the pre- and postoperative air-bone gap closure, in favor of cartilage grafting. The mean graft integration rate was 92.4 % in the cartilage group and 84.3 % in the TMF group (p < 0.05). The rates of re-perforations were 7.6 and 15.5 %, respectively (p < 0.05). Among the other complications of type I tympanoplasty, retraction pockets, otitis media with effusion, anterior blunting, and graft lateralization were usually surgically managed, whereas most of the rest were minor and could be dealt with conservatively. The graft integration rate in myringoplasty is higher after using cartilage, in comparison with fascia reconstructions (grade C strength of recommendation), and the rate of re-perforation is significantly lower. Although cartilage is primarily used as grafting material in cases of Eustachian tube dysfunction, adhesive otitis media, and subtotal perforation in everyday surgical practice, a wider utilization for the reconstruction of the tympanic membrane in myringoplasties can be recommended. 相似文献
50.
Liampas Ioannis Siouras Athanasios S. Siokas Vasileios Tsouris Zisis Rikos Dimitrios Brotis Alexandros Aloizou Athina-Maria Dastamani Metaxia Dardiotis Efthimios 《Journal of neurology》2022,269(1):184-196
Journal of Neurology - Although many studies have investigated the relationship between transient global amnesia (TGA) and migraine, to date, no meta-analysis has confirmed the existence and size... 相似文献