Association between Plasma Leptin Level and Systemic Inflammatory Markers in Patients with Aggressive Periodontitis

Background:

Increasing evidence supports an association between periodontitis and systemic diseases. Leptin is involved both in the energy metabolism and inflammatory processes and is suggested to be a link between periodontal infection and systemic health. The present study aimed to evaluate the peripheral leptin concentration in patients with aggressive periodontitis (AgP) and to explore the relationship between leptin and systemic inflammation.

Methods:

Ninety patients with AgP visiting the Clinic of the Periodontology Department, Peking University School and Hospital of Stomatology between July 2001 and May 2006, and 44 healthy controls (staff and student volunteers in the same institute) were recruited. Plasma levels of leptin and inflammatory cytokines including interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP) were measured by enzyme-linked immunosorbent assay. Correlation and multiple linear regression analysis were performed to analyze the association between plasma leptin level and other variables.

Results:

Plasma leptin level of AgP group was significantly higher than that of the control group (19.7 ± 4.4 ng/ml vs. 7.5 ± 1.3 ng/ml, P < 0.01). After controlling for age, gender, and body mass index, positive correlation was observed between plasma leptin concentration and log-transformed levels of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α and CRP), and the partial correlation coefficients ranged from 0.199 to 0.376 (P < 0.05). Log-transformed IL-1β and IL-6 levels entered the final regression model (standardized β were 0.422 and 0.461 respectively, P < 0.01).

Conclusions:

Elevated plasma leptin concentration may be associated with increased systemic levels of inflammatory markers in AgP patients.     

急诊医护人员遭受工作场所身体暴力事件后真实体验的质性研究

目的:总结急诊科医护人员遭受工作场所身体暴力事件后的真实体验,分析身体暴力事件对其造成的影响,以期引起相关部门的重视。方法:采用质性研究中传统的扎根理论研究方法,选择广州市3家三级甲等医院10例遭受过急诊科身体暴力事件的医护人员,进行半结构式访谈,遵循Colaizzi七步法,分析访谈内容。结果:遭受急诊科身体暴力事件的医护人员存在以委屈感、愤怒感、无助感、恐惧感、厌倦感为主的负面情绪,存在安全、心理辅导、被尊重、普及规章流程及法律知识、获得医院社会支持五个方面的需求。结论:医疗机构及社会相关部门应重视急诊科医护人员遭受身体暴力事件的情况,建立完善的遭受身体暴力事件后的支持系统,减少其负面情绪并满足其多种需求。     

飞行员体重指数与血糖、血脂、血尿酸的调查分析

目的对飞行员血糖、血脂、血尿酸与体重指数进行调查研究,为预防和控制飞行员慢性非传染性疾病提供科学依据。方法飞行员组1 032人,对照组635人,统计血糖、血脂、血尿酸水平以及体质指数并进行分析比较。结果飞行员组超重283例,超重率30.41%;肥胖83例,肥胖率7.8%。对照组635例,超重者240例,占37.8%;肥胖者91例,占14.3%,两组间的超重和肥胖率差异具有统计学意义(P值均为0.000 0)。飞行员组的高血糖、高血脂、高血尿酸发生率低于健康对照组,两组间差异有统计学意义(P0.05)。结论飞行员的超重和肥胖、高血脂发生率较高,应加强飞行员的健康教育和体质量管理,减少慢性疾病的发病危险因素。     

糖皮质激素治疗对急性呼吸窘迫综合征患者预后的影响

目的：探讨早期应用糖皮质激素（GC）治疗对急性呼吸窘迫综合征（ARDS）患者预后的影响。方法回顾性分析成都军区总医院2008年1月至2011年12月收治的所有ARDS病例的临床资料,选择符合2012年柏林ARDS诊断标准的成人患者,根据是否采用过GC治疗将患者分为GC组与非GC组。GC组患者均在ARDS发生48 h内开始静脉使用低剂量GC（＜5 mg·kg-1·d-1,均换算为氢化可的松的剂量）治疗,激素种类为甲泼尼松龙、地塞米松,疗程为7～21 d;而非GC组为ARDS发生后未使用GC治疗。比较两组患者机械通气时间、重症加强治疗病房（ICU）住院时间、总住院时间、医疗费用和28 d生存率的差异。结果共纳入ARDS患者117例,其中GC组56例（占47.86%）,非GC组61例（占52.14%）。与非GC组比较,GC组机械通气时间明显缩短〔d：0（0,2.50）比2.00（0,2.50）,Z＝2.015,P＝0.044〕,28 d生存率明显升高〔71.43%（40/56）比50.82%（31/61）,χ2＝5.198,P＝0.023〕,ICU住院时间〔d：7.50（2.00,11.00）比4.00（1.00,9.00）,Z＝1.879, P＝0.060〕和总住院时间〔d：16.00（10.00,27.75）比15.00（7.00,28.00）,Z＝0.592,P＝0.552〕差异无统计学意义,但非GC组患者的医疗费用显著低于GC组〔万元：3.15（1.51,5.78）比4.39（1.66,10.88）,Z＝2.204,P＝0.028〕。结论早期使用GC治疗ADRS患者可改善预后,特别是28 d生存率。     

品管圈在提高胃肠道术后患者功能锻炼依从性中的应用

目的探讨品管圈在提高胃肠道手术患者术后功能锻炼依从性中的应用效果。方法便利抽样选取2012年3-11月在南京军区福州总医院普通外科行胃肠道手术患者104例,按照入院时间分为对照组和观察组。对照组58例患者术后行常规胃肠道护理,观察组46例患者实施品管圈护理管理,通过同一评定标准评价两组患者功能锻炼的依从率。结果品管圈活动实施后,患者术后功能锻炼依从率从41.38%提升至82.61%,差异有统计学意义(P0.01)。结论品管圈活动的开展有利于提高胃肠道手术患者术后功能锻炼的依从性。