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Impact of proton pump inhibitors and dual antiplatelet therapy cessation on outcomes following percutaneous coronary intervention: Results From the PARIS Registry 下载免费PDF全文
Jaya Chandrasekhar MBBS Sameer Bansilal MBBS MPH Usman Baber MD MS Samantha Sartori PhD Melissa Aquino MS Serdar Farhan MD Birgit Vogel MD Michela Faggioni MD Gennaro Giustino MD Cono Ariti PhD Antonio Colombo MD Alaide Chieffo MD Annapoorna Kini MBBS Richard Saporito BS C. Michael Gibson MD Bernhard Witzenbichler MD David Cohen MD David Moliterno MD Thomas Stuckey MD Timothy Henry MD Stuart Pocock PhD George Dangas MD PhD P. Gabriel Steg MD Roxana Mehran MD 《Catheterization and cardiovascular interventions》2017,89(7):E217-E225
94.
Sex‐related differences in outcomes among men and women under 55 years of age with acute coronary syndrome undergoing percutaneous coronary intervention: Results from the PROMETHEUS study 下载免费PDF全文
Jaya Chandrasekhar MBBS Usman Baber MD MS Samantha Sartori PhD Michela Faggioni MD Melissa Aquino MS Annapoorna Kini MBBS William Weintraub MD Sunil Rao MD Samir Kapadia MD Sandra Weiss MD Craig Strauss MD Catalin Toma MD Brent Muhlestein MD Anthony DeFranco MD Mark Effron MD Stuart Keller BPharm Brian Baker PharmD Stuart Pocock PhD Timothy Henry MD Roxana Mehran MD 《Catheterization and cardiovascular interventions》2017,89(4):629-637
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Georgeanna J. Klingensmith Javier Aisenberg Francine Kaufman Mary Halvorson Eric Cruz Mary Ellen Riordan Chandrasekhar Varma Scott Pardo Maria T. Viggiani Jane F. Wallace Holly C. Schachner Timothy Bailey 《Pediatric diabetes》2013,14(5):350-357
The purpose of this study was to assess the performance and acceptability of a blood glucose meter coupled with a gaming system for children, adolescents, and young adults with type 1 diabetes. During an in‐clinic visit, duplicate blood samples were tested by subjects (N = 147; aged 5–24 yr) and health care providers (HCPs) to evaluate the accuracy and precision of the Didget® system. Subjects' meter results were compared against Yellow Springs Instruments (YSI) reference results and HCP results using least squares regression and error grid analyses. Precision was measured by average within‐subject and within‐HCP coefficient of variation (CV). During the home‐use component of this study, subjects (n = 58) tested their blood glucose at least two to three times daily for 3–5 d to evaluate routine use of the system. Subjects' meter results showed significant correlations with both YSI (r2 = 0.94; p < 0.001 for regression slope) and HCP results (r2 = 0.96; p < 0.001). Average within‐subject and within‐HCP CVs were 5.9 and 7.2%, respectively. Overall satisfaction was assessed by subjects, their parents or guardians, and HCP surveys. Subject satisfaction with the Didget® system was good to excellent; most subjects found the system easy to use, motivating, and helpful for building good blood glucose monitoring habits. Most HCPs agreed that the system fulfilled a need in diabetes management. In conclusion, the Didget® system was precise and clinically accurate in the hands of children, adolescents, and young adults with type 1 diabetes. 相似文献
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We discuss the rare case of a 68-year-old woman with Vogt-Koyanagi-Harada (VKH) syndrome and sensorineural hearing loss (SNHL) who was successfully treated with intratympanic corticosteroid injections. The patient had presented with bilaterally asymmetric (i.e., moderate and moderate to severe) SNHL, tinnitus, vertigo, and vitiligo. She received two intratympanic injections in her worse-hearing ear over the course of 1 month. Subsequent audiometry showed an immediate 5- to 10-dB improvement in her hearing across multiple frequencies, as well as a long-term improvement to near-normal thresholds. The hearing thresholds in her untreated ear remained stable. To the best of our knowledge, this is the first report of a patient with VKH syndrome who was successfully treated with intratympanic steroid application. 相似文献
99.
Sathishkumar K Elkins R Yallampalli U Balakrishnan M Yallampalli C 《Early human development》2011,87(6):407-414
Aims
The influence of prenatal factors on the development of arterial hypertension has gained considerable interest in recent years. We examined the effects of prenatal testosterone treatment on blood pressure in adult female rats. Further, to define the mechanisms whereby blood pressure may be raised, we examined vascular endothelial function and nitric oxide synthesis.Methods and Results
Testosterone propionate (0.5 mg/kg/day; SC) or vehicle was administered to pregnant Sprague-Dawley rats from gestational day 15-19. Maternal feed intake and plasma levels of steroid hormones were measured in the dams. In the female offspring, birth weight, growth rate, blood pressure, vascular reactivity, eNOS expression, and nitric oxide production were examined. In the pregnant rats, testosterone-treatment increased plasma testosterone levels by 2-fold without any significant changes in 17β-estradiol, progesterone and corticosterone levels. Testosterone-treatment did not affect maternal feed intake. The pups born to testosterone mothers were smaller in size but exhibited catch-up growth. The blood pressure in the testosterone offspring at 6 months of age was significantly higher compared to controls. Endothelium-intact mesenteric arteries from testosterone group exhibited increased contractile responses to phenylephrine, decreased vasodilation to acetylcholine and unaltered responses to sodium nitroprusside in comparison to control rats. Testosterone rats demonstrated decreased expression for eNOS, and reduced nitric oxide production.Conclusions
Our data show that elevated plasma maternal testosterone levels: (1) causes low birth weight followed by catch-up growth and hypertension in female offspring and (2) alters endothelium-dependent vascular responses. The endothelial dysfunction is associated with decreased activity/expression of eNOS. 相似文献100.