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排序方式: 共有620条查询结果,搜索用时 15 毫秒
81.
Ge Zhen Baber Usman Claessen Bimmer E. Chandrasekhar Jaya Chandiramani Rishi Li Shawn X. Sartori Samantha Kini Annapoorna S. Rao Sunil V. Weiss Sandra Henry Timothy D. Kapadia Samir Muhlestein Brent Strauss Craig Toma Catalin DeFranco Anthony Effron Mark B. Keller Stuart Baker Brian A. Pocock Stuart Dangas George Mehran Roxana 《Journal of thrombosis and thrombolysis》2019,47(1):42-50
Journal of Thrombosis and Thrombolysis - Left atrial contrast computed tomography (LA-CT) as well as transesophageal echocardiography (TEE) can exclude left atrial appendage (LAA) thrombus, but is... 相似文献
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Agent of choice for thrombolytic therapy (TT) in prosthetic valve thrombosis (PVT) is unknown. 84 mitral obstructive-PVT episodes treated with TT (43: Tenecteplase; 41: Streptokinase) were included in this prospective study. The incidence of primary end-point (CCS: complete clinical success, defined as complete or partial hemodynamic success with no complications or surgery) was 84.5% with recurrent PVT as a sole predictor. Bleeding and embolic manifestations were noted in 8.3% and 4.7% of episodes respectively. Tenecteplase use was associated with lower complication rate and a mitral EOA of <0.74 cm2 at presentation predicts the need for extended thrombolysis (accuracy, 78.6%). 相似文献
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Tanmoy Mondal Prasanna Kumar Juvvuna Agnete Kirkeby Sanhita Mitra Subazini Thankaswamy Kosalai Larissa Traxler Falk Hertwig Sara Wernig-Zorc Caroline Miranda Lily Deland Ruth Volland Christoph Bartenhagen Deniz Bartsch Sashidhar Bandaru Anne Engesser Santhilal Subhash Tommy Martinsson Helena Carén Chandrasekhar Kanduri 《Cancer cell》2018,33(3):417-434.e7
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Akila Srinivasan Sandhiya Selvarajan Sadishkumar Kamalanathan Tamilarasu Kadhiravan Nakka Chandrasekhar Prasanna Lakshmi Surendiran Adithan 《Phytotherapy research : PTR》2019,33(7):1898-1911
Diabetes mellitus is characterized by increased central arterial stiffness and endothelial dysfunction leading to increased risk of cardiovascular complications. The aim of this study is to evaluate the effect of Curcuma longa on arterial stiffness and endothelial dysfunction in patients with type 2 diabetes mellitus. This randomized controlled trial was conducted in 136 patients of type 2 diabetes. Among them, 114 completed at least one follow‐up visit and included for data analysis. Arterial stiffness parameters were measured at baseline and every month for 3 months and endothelial dysfunction markers at baseline and after 3 months of treatment with C. longa or placebo. These parameters were compared between the two groups. Both C. longa and placebo groups were comparable at baseline. After 3 months of treatment, C. longa produced significant reduction from baseline in carotid–femoral pulse wave velocity (p = .002), left brachial–ankle pulse wave velocity (p = .001), aortic augmentation pressure (p = .007), aortic augmentation index (p = .007), and aortic augmentation index at heart rate 75 (p = .018) as compared with the placebo group. Three months treatment with C. longa significantly decreases arterial stiffness as compared with placebo in type 2 diabetes mellitus patients. 相似文献
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Archana Laknaur Terri‐Lee Foster Lesley E. Bobb Aramandla Ramesh Gwinnett M. Ladson Darryl B. Hood Ayman Al‐Hendy Chandrasekhar Thota 《Journal of applied toxicology : JAT》2016,36(6):827-835
Etiology of preterm birth (PTB) is multifactorial; therefore, decreasing the incidence of PTB is a major challenge in the field of obstetrics. Epidemiological studies have reported an association between toxicants and PTB. However, there are no studies on the role of benzo[a]pyrene (BaP), an environmental toxicant, in the incidence of PTB. We first assessed the effects of BaP (150 and 300 µg kg–1 body weight) dosed via gavage from day 14 to 17 of pregnancy on gestation length in Long Evans rats. We further assessed the histopathology of the uterus, expression of inflammatory cytokines, contractile‐associated factors, histone deacetylases (HDACs) and NF?B‐p65 in myometrium collected on day 22 postpartum versus vehicle‐treated controls. In our study, rats exposed to BaP delivered prematurely (P < 0.05) compared to control. Hematoxylin and eosin staining of uterus showed squamous metaplasia, glandular and stromal hyperplasia in BaP‐exposed rats versus control. The concentrations of BaP metabolites measured by high‐pressure liquid chromatography were higher in uterine myometrium of BaP‐exposed rats while they were undetectable in controls. Quantitative real‐time polymerase chain reaction showed significant increases in mRNA expression of interleukin‐1β and ‐8, tumor necrosis factor‐α, connexin 43, cyclo‐oxygenase‐2 and prostaglandin F2α receptor as compared to controls (P < 0.05). Western blot analysis revealed that BaP exposure caused decreases in class I HDACs 1 and 3 and increases in class II HDAC 5, cyclo‐oxygenase‐2 and nuclear translocation of NFκB‐p65 relative to controls. Our results suggest that gestational exposure to BaP increases incidence of PTB through epigenetic changes that causes increases in the expression of contractile‐associated factors through the NFκB pathway. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
87.
Kiran S. Avadhani Jyothsna Manikkath Mradul Tiwari Misra Chandrasekhar Ashok Godavarthi Shimoga M. Vidya 《Drug delivery》2017,24(1):61-74
The present work attempts to develop and statistically optimize transfersomes containing EGCG and hyaluronic acid to synergize the UV radiation-protective ability of both compounds, along with imparting antioxidant and anti-aging effects. Transfersomes were prepared by thin film hydration technique, using soy phosphatidylcholine and sodium cholate, combined with high-pressure homogenization. They were characterized with respect to size, polydispersity index, zeta potential, morphology, entrapment efficiency, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), in vitro antioxidant activity and ex vivo skin permeation studies. Cell viability, lipid peroxidation, intracellular ROS levels and expression of MMPs (2 and 9) were determined in human keratinocyte cell lines (HaCaT). The composition of the transfersomes was statistically optimized by Design of Experiments using Box–Behnken design with four factors at three levels. The optimized transfersome formulation showed vesicle size, polydispersity index and zeta potential of 101.2?±?6.0?nm, 0.245?±?0.069 and ?44.8?±?5.24?mV, respectively. FTIR and DSC showed no interaction between EGCG and the selected excipients. XRD results revealed no form conversion of EGCG in its transfersomal form. The optimized transfersomes were found to increase the cell viability and reduce the lipid peroxidation, intracellular ROS and expression of MMPs in HaCaT cells. The optimized transfersomal formulation of EGCG and HA exhibited considerably higher skin permeation and deposition of EGCG than that observed with plain EGCG. The results underline the potential application of the developed transfersomes in sunscreen cream/lotions for improvement of UV radiation-protection along with deriving antioxidant and anti-aging effects. 相似文献
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Kilian Salerno May Gary Y Yang Nikhil I Khushalani Rameela Chandrasekhar Gregory E Wilding Leayn Flaherty Harish K Malhotra Richard C Russo John C Warner Johnny C Yap Renuka V Iyer Chukwumere E Nwogu Saikrishna S Yendamuri John F Gibbs Hector R Nava Dominick Lamonica Charles R Thomas Jr 《Journal of gastrointestinal oncology.》2010,1(1):7-15