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81.
Heterogeneity of autosomal dominant osteopetrosis 总被引:4,自引:0,他引:4
A review of the radiographs of 26 patients with autosomal dominant osteopetrosis disclosed two distinct and strictly family-related radiographic types. Both types had universal osteosclerosis. In type 1 the most striking finding was pronounced sclerosis of the cranial vault while the spine was almost unaffected. In type 2 the sclerosis of the skull was most pronounced at the base, the vertebrae always had end-plate thickening, and in the pelvis the iliac wings contained convex arcs of sclerotic bone. Age and sex distribution did not differ between the types. Autosomal dominant osteopetrosis may be a heterogeneous group of inherited bone disorders. 相似文献
82.
Results of nonlinear finite element analysis support the Schachar theory of accommodation and demonstrate that the long-held Helmholtz theory of accommodation is impossible. 相似文献
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84.
Paolo Emanuele PE Levi-Setti Andrea Borini Pasquale Patrizio Simone Bolli Vincenzo Vigiliano Roberto De Luca Giulia Scaravelli 《Journal of assisted reproduction and genetics》2016,33(1):123-128
Purpose
This study is a retrospective collection of aggregated data from all the Italian ART centers reporting to the Italian National Register from cycles started between January 2005 and December 2013.Methods
Data from both slow freezing (SF) and vitrification (V) were assessed for the period 2007–2013, while during the years 2005–2006 cryopreservation was exclusively performed by SF.Results
In the study period, a total of 2,526,024 oocytes were retrieved (from 378,543 retrievals), of which 1,346,061 (53.3 %) were inseminated in fresh cycles and 214,481 (8.5 %) were cryopreserved. Cryopreserved oocytes were used in 24,173 cycles yielding 19,453 transfer cycles (80.5 % of the thawing/warming cycles) and 3043 clinical pregnancies (15.6 % per transfer). A significant difference in implantation (8.7 vs 12.9 % OR 1.30 CI 1.20–1.40) and pregnancy rates per transfer (12.2 vs 14.9 % OR 1.34 CI 1.23–1.46) was found between SF and V. Complete outcome data was available for 2708 pregnancies (89.8 %), leading to 1882 deliveries and 2152 live births. Neonatal major congenital anomalies were 0.9 % (20/2152).Conclusions
A wide variation in pregnancy rates were found among different centers and lower rates were reported in donor cycles and in centers with more experience.85.
Berna DL Broekhuizen Alfred PE Sachs Arno W Hoes Karel GM Moons Jan WK van den Berg Willem H Dalinghaus Ernst Lammers Theo JM Verheij 《The British journal of general practice》2010,60(576):489-494
Background
Chronic obstructive pulmonary disease (COPD) and asthma are underdiagnosed in primary care.Aim
To determine how often COPD or asthma are present in middle-aged and older patients who consult their GP for persistent cough.Design of study
A cross-sectional study in 353 patients older than 50 years, visiting their GP for persistent cough and not known to have COPD or asthma.Setting
General practice in the Netherlands.Method
All participants underwent extensive diagnostic work-up, including symptoms, signs, spirometry, and body plethysmography. All results were studied by an expert panel to diagnose or exclude COPD and/or asthma. The reproducibility of the panel diagnosis was assessed by calculation of Cohen''s κ statistic in a sample of 41 participants.Results
Of the 353 participants, 102 (29%, 95% confidence interval [CI] = 24 to 34%) were diagnosed with COPD. In 14 of these 102 participants, both COPD and asthma were diagnosed (4%, 95% CI = 2 to 7%). Asthma (without COPD) was diagnosed in 23 (7%, 95% CI = 4 to 10%) participants. Mean duration of cough was 93 days (median 40 days). The reproducibility of the expert panel was good (Cohen''s κ = 0.90).Conclusion
In patients aged over 50 years who consult their GP for persistent cough, undetected COPD or asthma is frequently present. 相似文献86.
87.
聚丙交酯复合乙交酯微球经肝动脉化疗栓塞术治疗肝癌的动物实验 总被引:4,自引:0,他引:4
目的:在肝细胞癌动物模型上观察聚丙交酯复合乙交酯(PLcG)微球经肝动脉化疗栓塞术(TACE)治疗肝癌的疗效。方法:在雄性ACI大鼠(15例)肝包膜下植入Morris Hepatoma 3924A肝癌小瘤块(1mm3),移植术中13天时行磁共振检查,再经正中腹切开术和经胃十二指肠动脉逆行插管进行以下介入治疗:治疗组A(40mg PLcG 0.05mg丝裂霉素,4例),对照组B(0.05mg丝裂霉素+0.04mg碘化油+肝动脉结扎,4例)和对照组C(1.5ml生理盐水,7例),插管术后13天再次行磁共振术观察肝肿瘤体积变化。结果:在C组,肿瘤体积在实验期间增长27.12倍,在B组,肿瘤体积增长3.76倍,而在A组,肿瘤体积仅增长2.87倍。A组与C组肿瘤体积增长率在t检验时均有显著性差异(P<0.05),结论:在动物实验中将PLcG微球运用于TACE可明显抑制肝肿瘤生长。 相似文献
88.
89.
90.
Ultrastructural analysis of murine megakaryocyte maturation in vitro: comparison of big-cell and heterogeneous megakaryocyte colonies 总被引:1,自引:0,他引:1
Two morphologically distinct types of murine megakaryocyte (MK) colonies are present after three to seven days in soft agar culture: (a) "big-cell" colonies composed of ten to 30 large, mature-appearing megakaryocytes and (b) "heterogeneous" colonies consisting of approximately 100 or more cells at various stages of differentiation. Cytochemical and immunocytochemical techniques were used to study MK maturation in colonies as well as normal mouse bone marrow. Acetylcholinesterase (AChE), a specific marker for murine platelets and MK, was found in the perinuclear cisterna, endoplasmic reticulum, and occasionally, Golgi cisternae of MK in three-day big-cell colonies and immature bone marrow MK. MK in seven-day big-cell colonies and mature bone marrow MK showed additional reaction sites in the demarcation membrane system and occasional granules. In seven-day heterogeneous colonies, small cells resembled immature bone marrow MK with respect to AChE localization, whereas large cells corresponded to mature bone marrow MK. With immunogold procedures at the ultrastructural level, polyclonal antibodies against human platelet membrane glycoprotein IIIa and antimouse platelet antiserum labeled bone marrow MK and all MK from colonies grown in soft agar cultures for three to seven days. Granulocytes and macrophages in both bone marrow and soft agar cultures were negative for AChE and these immunocytochemical markers. These data indicate that the pattern of expression of AChE during maturation of MK is similar in vivo and in vitro and demonstrate, when using this marker at the fine-structural level, that a greater range of MK maturational stages is present in heterogeneous colonies than is observed in MK in big-cell colonies. Furthermore, we have confirmed that small cells in heterogeneous colonies are MK and that these colonies are composed solely of MK and their precursors. 相似文献