全文获取类型
收费全文 | 715篇 |
免费 | 38篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 22篇 |
妇产科学 | 29篇 |
基础医学 | 77篇 |
口腔科学 | 7篇 |
临床医学 | 24篇 |
内科学 | 151篇 |
皮肤病学 | 1篇 |
神经病学 | 60篇 |
特种医学 | 23篇 |
外科学 | 176篇 |
预防医学 | 24篇 |
眼科学 | 37篇 |
药学 | 86篇 |
中国医学 | 10篇 |
肿瘤学 | 28篇 |
出版年
2023年 | 7篇 |
2022年 | 9篇 |
2021年 | 21篇 |
2020年 | 17篇 |
2019年 | 18篇 |
2018年 | 17篇 |
2017年 | 16篇 |
2016年 | 8篇 |
2015年 | 6篇 |
2014年 | 18篇 |
2013年 | 27篇 |
2012年 | 41篇 |
2011年 | 30篇 |
2010年 | 20篇 |
2009年 | 20篇 |
2008年 | 39篇 |
2007年 | 33篇 |
2006年 | 41篇 |
2005年 | 40篇 |
2004年 | 41篇 |
2003年 | 37篇 |
2002年 | 37篇 |
2001年 | 24篇 |
2000年 | 34篇 |
1999年 | 30篇 |
1998年 | 8篇 |
1997年 | 6篇 |
1995年 | 5篇 |
1994年 | 3篇 |
1992年 | 15篇 |
1991年 | 11篇 |
1990年 | 9篇 |
1989年 | 6篇 |
1988年 | 6篇 |
1987年 | 5篇 |
1986年 | 7篇 |
1985年 | 6篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 6篇 |
1978年 | 4篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1973年 | 4篇 |
1965年 | 1篇 |
排序方式: 共有758条查询结果,搜索用时 93 毫秒
21.
Borrelli S De Nicola L Minutolo R Sagliocca A Garofalo C Liberti ME Pacilio M Iorio V Michini C Pirro L Conte G 《Giornale italiano di nefrologia》2012,29(4):418-424
International guidelines recommend to reduce blood pressure (BP) levels below 130/80 mmHg in non-dialysis chronic kidney disease (CKD) patients. However, this BP target has not been validated by randomized controlled trials and is mainly driven by data obtained in observational and post-hoc analyses suggesting that it improves the renal and, to some extent, cardiovascular prognosis. The inconclusive results on the prognostic role of the BP target in patients with CKD might also relate to the limited ability of office BP readings to adequately stratify the global risk of this population. In fact, alterations of the pressure profile (such as white-coat hypertension) and nighttime hypertension are common in CKD patients. Recent studies have demonstrated that ambulatory blood pressure monitoring (ABPM) is superior to clinic BP measurements in predicting renal death and cardiovascular events. Therefore, while waiting for the results from the ongoing randomized Systolic Blood Pressure Intervention Trial (SPRINT) comparing the effect on cardiorenal prognosis of two BP target levels, the more widespread use of ABPM is desirable in CKD patients. 相似文献
22.
Diamanti Luca Borrelli Paola Dubbioso Raffaele Capasso Margherita Morelli Claudia Lunetta Christian Petrucci Antonio Mora Gabriele Volanti Paolo Inghilleri Maurizio Tremolizzo Lucio Mandrioli Jessica Mazzini Letizia Vedovello Marcella Siciliano Gabriele Filosto Massimiliano Mat Sabrina Montomoli Cristina 《Neurological sciences》2022,43(5):3195-3200
Neurological Sciences - Dysphagia is a common symptom during the trajectory of ALS, and it can significantly impact on the quality of life and prognosis of patients. Nowadays, no specific tool for... 相似文献
23.
Borrelli Enrico Grosso Domenico Vella Giovanna Sacconi Riccardo Querques Lea Zucchiatti Ilaria Prascina Francesco Bandello Francesco Querques Giuseppe 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2020,258(12):2655-2660
Graefe's Archive for Clinical and Experimental Ophthalmology - To quantify the shrinking in outpatient and intravitreal injections’ volumes in a tertiary referral retina unit secondary to... 相似文献
24.
25.
26.
Mascolo N Mereto E Borrelli F Orsi P Sini D Izzo AA Massa B Boggio M Capasso F 《Digestive diseases and sciences》1999,44(11):2226-2230
Current evidence suggests that aberrant cryptfoci (ACF) can be used to evaluate agents for theirpotential colon carcinogenic activity. The aim of thepresent study was to determine whether senna pod extract (SE) itself induces ACF and tumors in the ratcolon or increases the development of ACF and tumorsinduced by azoxymethane (AOM). A daily administration ofSE 10 mg/kg by mouth for 13-28 weeks produced a weak laxative effect but did not itself causethe appearance of ACF or tumors. The numbers of ACF andtumors induced by AOM were, however, increased by a doseof SE (100 mg/kg) able to induce chronic diarrhea over three months. These resultssuggest that SE does not cause the appearance of ACF ortumors in the rat colon nor does it have a promotingeffect when given to rats at a dose that produceslaxation (10 mg/kg), whereas a diarrhogenic dose (100mg/kg) increases the appearance of tumors induced byAOM. 相似文献
27.
28.
Marco Matucci-Cerinic Francesco Borrelli Sergio Generini Alfredo Cantelmo Isabella Marcucci Fabrizio Martelli Paolo Romagnoli Stefano Bacci Angelo Conz Paolo Marinelli Simone Marabini 《Arthritis \u0026amp; Rheumatology》1995,38(11):1687-1693
Objective. To study the antiinflammatory effect of different doses of intraarticular somatostatin in experimental arthritis in rabbits. Methods. Chronic arthritis was induced by a single injection of fibrin into the knee joint of rabbits previously sensitized to this antigen. The effects of sequential intraarticular injections of somatostatin into the rabbit knee, at doses of 500, 750, and 1,000 μg, were monitored by measuringknee joint circumferences and hematologic parameters. The measurements were compared with those obtained following use of triamcinolone acetonide and placebo. At the end of the experiments, the knee joints were examined histologically. Results. Somatostatin treatment induced a statistically significant and dose-related reduction of knee joint swelling. This effect was shorter than that produced by triamcinolone acetonide; however, the antiinflammatory activity elicited by successive doses of triamcinolone acetonide declined both in extent and duration, while the effects of somatostatin remained unchanged at each successive treatment. Histopatho-logic observations showed that both somatostatin and triamcinolone acetonide reduced the inflammatory signs in the joint structures, although triamcinolone acetonide appeared to be more effective. Conclusion. These findings suggest that somatostatin exerts an antiinflammatory effect in this model of experimental arthritis and may represent a valid and safer alternative to corticosteroids for intraarticular therapy of arthritis. 相似文献
29.
Francesca Borrelli Nicola Borbone Raffaele Capasso Domenico Montesano Simona De Marino Gabriella Aviello Giovanni Aprea Stefania Masone Angelo A. Izzo 《Journal of ethnopharmacology》2009
Ethnopharmacological importance
Celastrus paniculatus Willd. (Celastraceae) is an Ayurvedic remedy used for the treatment of a number of diseases, including bowel spasms.Aim of the study
To investigate the mode of the relaxing action of a methanolic extract prepared from the seeds of Celastrus paniculatus (CPE, 0.0001–10 μg/mL) in the rat ileum and to try to confirm on human tissues the intestinal pharmacological activity of the extract.Materials and methods
The relaxant effect of CPE was studied in vitro by evaluating its effect on the spontaneous contractions of the isolated ileum.Results
CPE exerted a tetrodotoxin- and ω-conotoxin-resistant inhibitory effect on rat ileum motility (IC50: 0.24 ± 0.02 μg/mL; Emax: 99.0 ± 0.60%). The inhibitory effect was reduced by nifedipine but not by cyclopiazonic acid. Experiments with specific antagonists enabled us to exclude the involvement of the main endogenous spasmogenic (i.e. acetylcholine and tachykinins) and relaxing (noradrenaline, nitric oxide, ATP) compounds. CPE also relaxed the isolated human ileum (IC50: 0.26 ± 0.02 μg/mL; Emax: 99.1 ± 0.46%).Conclusion
It is concluded that (i) CPE exerted a powerful myogenic and L-type Ca2+-dependent relaxing effect in the isolated rat ileum and that (ii) the human ileum is sensitive to the inhibitory effect of CPE. If confirmed in vivo, our data could explain the traditional use of this herb in the treatment of intestinal spasms. 相似文献30.