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71.
Milburn Norweeta G. Klomhaus Alexandra M. Comulada W. Scott Lopez Susana A. Bath Eraka Amani Bita Jackson Jessica Lee Alex Rice Eric Semaan Alan Kim Bo-Kyung Elizabeth 《Prevention science》2020,21(8):1048-1058
Prevention Science - Behavioral family interventions are an effective way to intervene to prevent negative developmental outcomes for adolescents. Participation in family interventions encompasses... 相似文献
72.
Biliary reconstruction in liver transplant patients with primary sclerosing cholangitis,duct‐to‐duct or Roux‐en‐Y? 下载免费PDF全文
73.
Weiss PF Arabshahi B Johnson A Bilaniuk LT Zarnow D Cahill AM Feudtner C Cron RQ 《Arthritis and rheumatism》2008,58(4):1189-1196
OBJECTIVE: To determine the prevalence of temporomandibular joint (TMJ) disease in a cohort of children with new-onset juvenile idiopathic arthritis (JIA), and to compare magnetic resonance imaging (MRI) with ultrasound (US) for the detection of acute and chronic changes of TMJ arthritis. METHODS: Between January 2005 and April 2007, children with newly diagnosed JIA were prospectively evaluated for TMJ arthritis. Prior to imaging, jaw pain and disability were assessed with questionnaires and physical examination. The TMJs of all patients were imaged with MRI and US within 8 weeks of diagnosis. RESULTS: Of the 32 patients enrolled, 78% were female, and the median age was 8.6 years (range 1.5-17.2 years). Acute TMJ arthritis was diagnosed in 75% of the children by MRI and in none by US; chronic arthritis was diagnosed in 69% by MRI and in 28% by US. Findings of both acute and chronic TMJ disease were detected by MRI in 53% of the patients. Of those with acute TMJ arthritis, 71% were asymptomatic, and 63% had normal findings on jaw examination. Fifty-six percent of patients with acute disease had an improved maximal incisal opening after corticosteroid injection. Among these responders, 56% had been asymptomatic and had normal jaw examination findings. CONCLUSION: TMJ arthritis was present in the majority of patients with new-onset JIA. Findings on MRI along with responses to treatment among asymptomatic patients with normal jaw examination findings suggest that a history review and physical examination are not sufficient to screen for TMJ disease. Our results also suggest that MRI and US findings are not well correlated, and that MRI is preferable for the detection of TMJ disease in new-onset JIA. 相似文献
74.
Amphotericin B-resistant Aspergillus flavus infection successfully treated with caspofungin,a novel antifungal agent 总被引:6,自引:0,他引:6
Koss T Bagheri B Zeana C Romagnoli MF Grossman ME 《Journal of the American Academy of Dermatology》2002,46(6):945-947
Invasive aspergillosis is uncommon in immunocompetent hosts but is the second most common opportunistic fungal infection in immunocompromised patients. There has been a dramatic increase in the incidence of life-threatening aspergillosis during the past 2 decades, and the morbidity and mortality of these infections despite antifungal therapy remain unacceptably high. We describe a patient with amphotericin B-resistant Aspergillus flavus successfully treated with caspofungin, an agent belonging to a new class of antifungal drugs. Caspofungin shows great promise in the treatment of invasive aspergillosis. 相似文献
75.
Jeffrey N. Weitzel MD Susan L. Neuhausen PhD Aaron Adamson PhD Shu Tao PhD Charité Ricker MS Asaf Maoz MD Margalit Rosenblatt BA Bita Nehoray MS Sharon Sand BA Linda Steele MS Gary Unzeitig MD Nancy Feldman MD Amie M. Blanco MS Donglei Hu PhD Scott Huntsman MS Danielle Castillo BS Christopher Haiman ScD Thomas Slavin MD Elad Ziv MD 《Cancer》2019,125(16):2829-2836
76.
Mayada Helal Neda Mazaheri Bita Shalbafan Reza Azizi Malamiri Nafi Dilaver Rebecca Buchert Javad Mohammadiasl Neda Golchin Alireza Sedaghat Mohammad Yahya Vahidi Mehrjardi Tobias B. Haack Olaf Riess Wendy K. Chung Hamid Galehdari Gholamreza Shariati Reza Maroofian 《Neurological sciences》2018,39(11):1917-1925
Biallelic mutations of the alsin Rho guanine nucleotide exchange factor (ALS2) gene cause a group of overlapping autosomal recessive neurodegenerative disorders including infantile-onset ascending hereditary spastic paralysis (IAHSP), juvenile primary lateral sclerosis (JPLS), and juvenile amyotrophic lateral sclerosis (JALS/ALS2), caused by retrograde degeneration of the upper motor neurons of the pyramidal tracts. Here, we describe 11 individuals with IAHSP, aged 2–48 years, with IAHSP from three unrelated consanguineous Iranian families carrying the homozygous c.1640+1G>A founder mutation in ALS2. Three affected siblings from one family exhibit generalized dystonia which has not been previously described in families with IAHSP and has only been reported in three unrelated consanguineous families with JALS/ALS2. We report the oldest individuals with IAHSP to date and provide evidence that these patients survive well into their late 40s with preserved cognition and normal eye movements. Our study delineates the phenotypic spectrum of IAHSP and ALS2-related disorders and provides valuable insights into the natural disease course. 相似文献
77.
78.
Bita Nickkholgh Sivanandane Sittadjody Karina Ordonez Michael Bryan Rothberg K. C. Balaji 《The Prostate》2019,79(9):1053-1058
Protein Kinase D1 (PrKD1) functions as a tumor and metastasis suppressor in several human cancers by influencing cell-cycle progression. However, the exact mechanism of cell-cycle regulation by PrKD1 is unclear. Overexpression and ectopic expression of PrKD1 induces G1 arrest in cancer cell lines. Because checkpoint kinases (CHEKs) are known to play a role in progression through the G1 phase, we downregulated CHEK1, which did not overcome the G1 arrest induced by PrKD1. Using in vitro phosphorylation and Western blot assays, we showed that PrKD1 phosphorylates all CDC25 isoforms (known substrates of CHEK kinases), independent from CHEK kinases, suggesting that direct phosphorylation of CDC25 by PrKD1 may be an alternate mechanism of G1 arrest. The study has identified a molecular mechanism for the influence of PrKD1 in cell-cycle progression. 相似文献
79.
80.
Skinner HD Garden AS Rosenthal DI Ang KK Morrison WH Esmaeli B Pinnix CC Frank SJ 《Cancer》2011,117(12):2801-2810