全文获取类型
收费全文 | 3489篇 |
免费 | 187篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 37篇 |
儿科学 | 69篇 |
妇产科学 | 44篇 |
基础医学 | 394篇 |
口腔科学 | 136篇 |
临床医学 | 261篇 |
内科学 | 857篇 |
皮肤病学 | 36篇 |
神经病学 | 450篇 |
特种医学 | 74篇 |
外科学 | 587篇 |
综合类 | 18篇 |
一般理论 | 1篇 |
预防医学 | 276篇 |
眼科学 | 63篇 |
药学 | 186篇 |
中国医学 | 5篇 |
肿瘤学 | 192篇 |
出版年
2024年 | 5篇 |
2023年 | 30篇 |
2022年 | 67篇 |
2021年 | 122篇 |
2020年 | 76篇 |
2019年 | 104篇 |
2018年 | 108篇 |
2017年 | 69篇 |
2016年 | 110篇 |
2015年 | 82篇 |
2014年 | 155篇 |
2013年 | 153篇 |
2012年 | 278篇 |
2011年 | 286篇 |
2010年 | 154篇 |
2009年 | 146篇 |
2008年 | 211篇 |
2007年 | 226篇 |
2006年 | 210篇 |
2005年 | 220篇 |
2004年 | 165篇 |
2003年 | 150篇 |
2002年 | 144篇 |
2001年 | 67篇 |
2000年 | 37篇 |
1999年 | 44篇 |
1998年 | 20篇 |
1997年 | 26篇 |
1996年 | 22篇 |
1995年 | 9篇 |
1994年 | 8篇 |
1993年 | 8篇 |
1992年 | 13篇 |
1991年 | 15篇 |
1990年 | 15篇 |
1989年 | 10篇 |
1988年 | 11篇 |
1987年 | 6篇 |
1986年 | 15篇 |
1984年 | 9篇 |
1983年 | 9篇 |
1982年 | 8篇 |
1980年 | 5篇 |
1979年 | 4篇 |
1978年 | 11篇 |
1977年 | 5篇 |
1976年 | 8篇 |
1969年 | 5篇 |
1968年 | 3篇 |
1965年 | 3篇 |
排序方式: 共有3686条查询结果,搜索用时 125 毫秒
91.
92.
Bryony Armson Antonello Di Nardo Dickson M. Nyaguthii Beatriz Sanz‐Bernardo Philip M. Kitala Eunice Chepkwony Valerie Mioulet Donald P. King Nicholas A. Lyons 《Transboundary and Emerging Diseases》2020,67(4):1532-1542
This study investigated the potential of pooled milk as an alternative sample type for foot‐and‐mouth disease (FMD) surveillance. Real‐time RT‐PCR (rRT‐PCR) results of pooled milk samples collected weekly from five pooling facilities in Nakuru County, Kenya, were compared with half‐month reports of household‐level incidence of FMD. These periodic cross‐sectional surveys of smallholder farmers were powered to detect a threshold household‐level FMD incidence of 2.5% and collected information on trends in milk production and sales. FMD virus (FMDV) RNA was detected in 9/219 milk samples, and using a type‐specific rRT‐PCR, serotype SAT 1 was identified in 3/9 of these positive samples, concurrent with confirmed outbreaks in the study area. Four milk samples were FMDV RNA‐positive during the half‐months when at least one farmer reported FMD; that is, the household‐level clinical incidence was above a threshold of 2.5%. Additionally, some milk samples were FMDV RNA‐positive when there were no reports of FMD by farmers. These results indicate that the pooled milk surveillance system can detect FMD household‐level incidence at a 2.5% threshold when up to 26% of farmers contributed milk to pooling facilities, but perhaps even at lower levels of infection (i.e., below 2.5%), or when conventional disease reporting systems fail. Further studies are required to establish a more precise correlation with estimates of household‐level clinical incidence, to fully evaluate the reliability of this approach. However, this pilot study highlights the potential use of this non‐invasive, routinely collected, cost‐effective surveillance tool, to address some of the existing limitations of traditional surveillance methods. 相似文献
93.
Vitor Massaro Takamatsu Sagae Igor Braga Ribeiro Diogo Turiani Hourneaux de Moura Vitor Ottoboni Brunaldi Fernanda Prado Logiudice Mateus Pereira Funari Elisa Ryoka Baba Wanderley Marques Bernardo Eduardo Guimares Hourneaux de Moura 《Surgical endoscopy》2020,34(3):1025-1034
Minimally invasive treatment of early-stage rectal lesion has presented good results, with lower morbidity than surgical resection. Transanal endoscopic microsurgery (TEM) and transanal minimally invasive surgery (TAMIS) are the main methods of transanal surgery. However, endoscopic submucosal dissection (ESD) has been gaining ground because it allows en bloc resections with low recurrence rates. The aim of this study was to analyze ESD in comparison with transanal endoscopic surgery. We searched MEDLINE, EMBASE, SciELO, Cochrane CENTRAL, and Lilacs/Bireme with no restrictions on the date or language of publication. The outcomes evaluated were recurrence rate, complete (R0) resection rate, en bloc resection rate, length of hospital stay, duration of the procedure, and complication rate. Six retrospective cohort studies involving a collective total of 326 patients—191 in the ESD group and 135 in the transanal endoscopic surgery group were conducted. There were no statistically significant differences between the groups for any of the outcomes evaluated. For the minimally invasive treatment of early rectal tumor, ESD and surgical techniques do not differ in terms of local recurrence, en bloc resection rate, R0 resection rate, duration of the procedure, length of hospital stay, or complication rate, however, evidence is very low. 相似文献
94.
95.
Andrea Minervini Gianni Vittori Alessandro Antonelli Antonio Celia Simone Crivellaro Donato Dente Vincenzo Di Santo Bruno Frea Mauro Gacci Alberto Gritti Lorenzo Masieri Alessandro Morlacco Angelo Porreca Bernardo Rocco Paolo Parma Claudio Simeone Stefano Zaramella Marco Carini Sergio Serni 《World journal of urology》2014,32(1):295-295
96.
Bernardo Innocenti Ömer Faruk Bilgen Luc Labey G. Harry van Lenthe Jos Vander Sloten Fabio Catani 《The Journal of arthroplasty》2014
The aim of this study was to quantify the effects of understuffing and overstuffing UKA on bone stresses, load distribution and ligament strains. For that purpose, a numerical knee model of a cadaveric knee was developed and was validated against experimental measurements on that same knee. Good agreement was found among the numerical and experimental results. This study showed that, even if a medial UKA is well-aligned with normal soft tissue tension and with correct thickness of the tibia component, it induces a stiffness modification in the joint that alters the load distribution between the medial and lateral compartments, the bone stress and the ligament strain potentially leading to an osteoarthritic progression. 相似文献
97.
Michael S. Leapman MD Ghalib Jibara MD MPH Parissa Tabrizian MD Bernardo Franssen MD Ming-Jim Yang MD Anya Romanoff MD Simon J. Hall MD Michael Palese MD Umut Sarpel MD Spiros Hiotis MD PhD Daniel Labow MD 《Annals of surgical oncology》2014,21(4):1153-1158
Background
Cytoreductive surgery (CRS) with heated intraperitoneal chemotherapy (HIPEC) has gained acceptance in the treatment of peritoneal carcinomatosis with reported morbidity and mortality rates of 27–56 and 0–11 %, respectively. The safety and oncologic outcome of genitourinary repair at the time of CRS and HIPEC remains unclear.Methods
We identified 170 patients who underwent CRS-HIPEC at our institution between July 2007 and August 2011 with a minimum follow-up of 6 months. Thirty-four (20 %) underwent concomitant urologic reconstruction at the time of CRS-HIPEC and were matched by disease burden (intraoperative peritoneal cancer index [PCI]) and extent of surgery (ΔPCI) with a cohort of 38 (22.3 %) subjects without genitourinary involvement. The primary end points considered for this analysis included the development of major surgical (Clavien–Dindo Class III–V) complications and overall survival.Results
Median follow-up was 9.4 months. The most commonly performed urologic interventions included partial cystectomy with primary repair in 23 (65.7 %) and segmental ureteral resection and repair in 11 (31.4 %). Patients with genitourinary reconstruction had more total organ involvement (6.5 vs. 4.3, p < 0.001) and more commonly underwent enteric anastomoses (82.4 vs. 57.9 %, p = 0.025). No significant differences were observed with regard to major morbidity, need for transfusion, operative time, intensive care unit admission, or length of stay. Among patients with appendiceal or colonic tumors (n = 46), overall survival was similar between genitourinary reconstruction and matched cohorts: 22.5 versus 15.1 months, respectively (p = 0.66).Conclusions
Genitourinary reconstruction at the time of CRS-HIPEC occurs more commonly in patients with extensive disease burden undergoing radical debulking, yet does not adversely influence surgical morbidity or survival. 相似文献98.
Matthias May Luca Cindolo Richard Zigeuner Ottavio De Cobelli Bernardo Rocco Cosimo De Nunzio Andrea Tubaro Ioman Coman Michael Truss Orietta Dalpiaz Ingmar Wolff Bogdan Feciche Fabian Fenske Martin Pichler Luigi Schips Robert S. Figenshau Kerry Madison Manuel Sánchez-Chapado Sabine Brookman-May 《Urologic oncology》2014,32(8):1252-1258
ObjectivesTo analyze clinicopathological features and survival of surgically treated patients with renal cell carcinoma (RCC)≥80 years of age in comparison with patients between the ages of 60 and 70 years.Materials and methodsThe data for 2,516 patients with a median follow-up of 57 months were retrieved from a multinational database (Collaborative Research on Renal Neoplasms Association [CORONA]), including data for 6,234 consecutive patients with RCC after radical or partial nephrectomy. Comparative analysis of clinicopathological features of 241 octogenarians (3.9% of the database) and 2,275 reference patients between the ages of 60 and 70 years (36.5%) was performed. Multivariable regression analysis adjusted for competing risks was applied to identify the effect of advanced age on cancer-specific mortality (CSM) and other-cause mortality (OCM). Furthermore, instrumental variable analysis was employed to reduce residual confounding by unmeasured parameters.ResultsSignificantly more women were present (50% vs. 40%, P = 0.004), and significantly less often nephron-sparing surgery was performed in octogenarians compared with the reference group (11% vs. 20%, P<0.001). Although median tumor size and stages did not significantly defer, older patients less often had advanced or metastatic disease (N+/M1) (4.6% vs. 9.6%, P = 0.009). On multivariable analysis, higher CSM (hazard ratio = 1.48, P = 0.042) and OCM rates (hazard ratio = 4.32, P<0.001) were detectable in octogenarians (c-indices = 0.85 and 0.72, respectively). Integration of the variable age group in multivariable models significantly increased the predictive accuracy regarding OCM (6%, P<0.001), but not for CSM. Limitations are based on the retrospective study design.ConclusionsOctogenarian patients with RCC significantly differ in clinical features and display significantly higher CSM and OCM rates in comparison with their younger counterparts. 相似文献
99.
Giorgio A. Medranda MD Shannon Lance DO Ron Waksman MD Nelson L. Bernardo MD 《Catheterization and cardiovascular interventions》2021,97(6):1218-1220
Congenital left main (LM) coronary artery to right atrium fistulas with progression to aneurysm development are rare. Most patients remain asymptomatic, but for those with progressive symptoms, intervention is required. However, there are potential life-threatening complications associated with surgical intervention. We present a case of an extremely rare markedly aneurysmal LM to right atrial fistula treated with surgical ligation complicated by inferolateral ST-elevation myocardial infarction several days post-operatively treated successfully using mechanical aspiration thrombectomy, a stent-retriever, balloon angioplasty, and subsequent intravascular ultrasound-guided percutaneous coronary intervention with drug-eluting stent. 相似文献
100.
Amir Aziz MRCP PhD Gurbir Bhatia MD MRCP Michael Pitt MD MRCP Anirban Choudhury MD MRCP Ahmed Hailan MD FRCP Subramanya Upadhyaya MD MRCP Leong Lee MD MRCP Luca Testa MD Matteo Casenghi MD Alfonso Ielasi MD Bernardo Cortese MD Hannah Rides MSc Sandeep Basavarajaiah MD MRCP FESC 《Catheterization and cardiovascular interventions》2021,98(2):225-235