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Shobha Narahari Abida Juwle Subhankar Basak Dhananjaya Saranath 《Infection, genetics and evolution》2009,9(4):643-645
Viral hepatitis represents a major global health problem with 170 million Hepatitis C Virus (HCV) carriers worldwide, and 12–13 million HCV carriers in India. HCV genotypes are of clinical significance in indicating drug responsiveness and prognosis of the patient. The HCV genotypes are of epidemiologic significance as well, as they are indicative of transmission route of infection and have not been extensively studied in the Indian context. In the current study, HCV genotyping was examined in 2118 patients from different geographic regions of India. HCV was detected by PCR amplification of 5′ UTR and core-envelope1 regions, followed by genotyping using nucleotide sequencing and analysis with NCBI tool (http://www.ncbi.nlm.nih.gov/projects/genotyping/formpage.cgi). HCV genotype distribution in the 2118 Indian patients demonstrated prevalence of HCV3 (3a/3b primarily) in 62% and HCV1 (1a/1b primarily) in 31% patients. The predominance of HCV3 was significant in northern (p = 0.01) and eastern (p = 0.008) regions of India. HCV types 2, 4, 5, and 6 were detected in 0.05–4.5% of the patient group. Thus, our studies demonstrate HCV genotype prevalence in the cohort group in different regions of India. 相似文献
3.
BACKGROUND: Middle ear pathology, either otitis media with effusion or
tubal dysfunction, is frequently seen in day-care centre children.
Recognition and early treatment of this condition is crucial to the
prevention of chronic otitis media, which is a major cause of hearing loss
in later life. OBJECTIVES: We aimed to reveal the incidence of silent
otitis media in day-care centre children and to determine the predisposing
factors, risk factors and the awareness of the parents of the middle ear
disease of their children. METHOD: Two hundred and thirteen children, aged
3-6 years, were screened in four daycare centres. A questionnaire was
prepared that would reveal the predisposing factors. Information was
gathered from both the parents and teachers. Children were examined by
otoscopy, pneumotoscopy, tympanometry and X-rays for sinus pathology.
RESULTS: Forty-three of 213 children had middle ear pathology; 39 of them
were confirmed by tympanometry; 56.1 % of children had some degree of sinus
pathology. We revealed that, although most of the children do not have the
risk factors, they develop middle ear pathology. Among the parents, 81.4%
of them were unaware of the condition. CONCLUSION: Early diagnosis of
middle ear pathologies is necessary for prevention of future complications.
In early stages the condition is silent. We emphasize the importance of the
primary care physician's role in diagnosing the early stages of middle ear
pathologies and recommend that teaching of otoscopic and pneumotoscopic
skills should be part of the training for family physicians.
相似文献
4.
Bulent Urman Cengiz Alatas Senai Aksoy Alp Nuhoglu Aycan Sertac Basak Balaban 《Journal of assisted reproduction and genetics》1998,15(3):125-128
Purpose:
Our purpose was to determine the feasibility and efficacy of performing testicular or epididymal sperm retrieval prior to the injection of human chorionic gonadotropin (hCG).
Methods:
This report deals with 87 sperm-positive percutaneous epididymal sperm aspiration (PESA), percutaneous testicular sperm aspiration (PTSA), or testicular sperm extraction (TESE) cycles. All sperm retrieval procedures were performed prior to administration of hCG to the women. Retrieved spermatozoa were cultured in vitro in simple medium for approximately 40 hr prior to intracyto-plasmic sperm injection.
Results:
In all but one cycle in which TESE was performed for nonobstructive azoospermia, motile sperm were available for ICSI. The overall fertilization rate was 53%. Pregnancy rate per transfer and implantation rate per embryo were 41.2 and 15.7%, respectively.
Conclusions:
Satisfactory fertilization and pregnancy rates can be achieved when PESA, PTSA, or TESE is performed prior to the injection of hCG followed by in vitro culture of spermatozoa approximately 40 hr before ICSI. Scheduling of testicular or epididymal sperm retrieval cases in this way appears to ease the workload on laboratory and operating room personnel. Furthermore, withholding hCG when sperm is absent may obviate the unnecessary risk of ovarian hyperstimulation when spermatozoa cannot be retrieved. 相似文献
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Huseyin Ozkurt MD Merve Meltem Cenker MD Firat Keskiner MD Muzaffer Basak MD 《Journal of pediatric and adolescent gynecology》2009,22(4):e57-e60
Congenital absence of uterus and vagina, the Mayer-Rokitansky-Küster-Hauser Syndrome (MRKHS), results from defective müllerian duct development during female embryogenesis; it is the second most common cause of primary amenorrhea. Atypical forms of MRKHS (type B) represent a heterogeneous group of disorders with associated anomalies of other organ systems which frequently includes the renal and skeletal systems and several individually occurring malformations.We report two cases with MRKHS in which we diagnosed situs inversus totalis incidentally during radiologic examinations. Abdominal situs inversus describes the mirror-image arrangement of the intra-abdominal organs in the abdominal cavity and it is characterized by the presence of multiple congenital anomalies.In this report we attempt to question whether the association between MRKHS and situs inversus is a rare feature of the müllerian dysgenetic spectrum or whether it is the result of random association. 相似文献
7.
Demir Arzu Meltem Aydin Fatma Acar Banu Kurt Tuba Poyraz Aylar Kiremitci Saba Gülleroglu Basak Azili Müjdem Nur Bayrakci Umut Selda 《Clinical rheumatology》2021,40(9):3817-3825
Clinical Rheumatology - Autoimmune pancreatitis (AIP) type 1 is an IgG4-related disease (IgG4-RD), characterized by inflammatory pseudotumors and histologically by dense lymphoplasmacytic... 相似文献
8.
Ozturk Gokce Birsen Gogus Feride Bolayir Basak Tecer Duygu Gokce Onur Eroglu Altinova Alev Balos Toruner Fusun Akturk Mujde 《Pituitary》2020,23(4):338-346
Pituitary - Although it is well known that acromegaly causes enlargement in the extremities, studies investigating the effects of acromegaly on tendons, muscles and soft tissue are limited. The... 相似文献
9.