全文获取类型
收费全文 | 213篇 |
免费 | 12篇 |
专业分类
儿科学 | 2篇 |
妇产科学 | 3篇 |
基础医学 | 1篇 |
临床医学 | 4篇 |
内科学 | 9篇 |
神经病学 | 1篇 |
特种医学 | 1篇 |
外科学 | 3篇 |
预防医学 | 2篇 |
眼科学 | 195篇 |
药学 | 2篇 |
肿瘤学 | 2篇 |
出版年
2022年 | 4篇 |
2021年 | 16篇 |
2020年 | 10篇 |
2019年 | 5篇 |
2018年 | 11篇 |
2017年 | 2篇 |
2016年 | 9篇 |
2015年 | 13篇 |
2014年 | 11篇 |
2013年 | 19篇 |
2012年 | 25篇 |
2011年 | 13篇 |
2010年 | 3篇 |
2008年 | 2篇 |
2007年 | 8篇 |
2006年 | 7篇 |
2005年 | 7篇 |
2004年 | 5篇 |
2003年 | 4篇 |
2002年 | 13篇 |
2001年 | 8篇 |
2000年 | 4篇 |
1999年 | 5篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 4篇 |
1993年 | 3篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 3篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
排序方式: 共有225条查询结果,搜索用时 15 毫秒
101.
Optical coherence tomography angiography in treated type 2 neovascularization undergoing monthly anti‐VEGF treatment 下载免费PDF全文
102.
103.
F. Bandello MD Roman Pognuz A. Polito MD A. Pirracchio MD F. Menchini MD M. Ambesi MD 《Seminars in ophthalmology》2013,28(4):251-258
Purpose. to propose and describe a new classification of diabetic macular edema (DME) based on its etiopathogenetic features and to present efficacy and safety data on medical and laser treatments currently used and under investigation. Methods. available literature on DME has been reviewed and information provided by contact lens biomicroscopy, fluorescein angiography and optical coherence tomomography has been combined; published data from trials and reports investigating effectiveness of medical and laser treatments were also analyzed. Results. DME was classified according to its main etiopathogenetic components: prevalently retinovascular, tractional and with taut attached posterior hyaloid, each of them having peculiar aspects on fundus, angiographic and tomographic examination. Focal laser treatment remains the only effective intervention, as shown by a large randomized controlled trial, but new less-invasive photocoagulation strategies (i.e., light laser photocoagulation and subthreshold micropulse diode laser) as well as pharmacological approaches (i.e., antioxidants, PKC inhibitors, aldose-reductase and AGE inhibitors, VEGF inhibitors, intravitreal triamcinolone) are emerging. Conclusions. based on our review a classification of DME was developed that may prove useful in making the appropriate treatment decision; the new laser and pharmacological treatments currently investigated are promising and need to be confirmed by large, controlled clinical trials. 相似文献
104.
105.
Ilaria Zucchiatti Elisabetta Miserocchi Riccardo Sacconi Francesco Bandello Giulio Modorati 《Case reports in ophthalmology》2013,4(3):287-293
Birdshot chorioretinopathy (BSCR) is a relatively rare form of uveitis, which is strongly correlated with the histocompatibility leukocyte antigen (HLA)-A29 class I type. Nevertheless, HLA typing is not diagnostic. The purpose of the present study was to retrospectively evaluate the ocular manifestations associated with the presence of HLA-A29 other than typical BSCR. Charts of consecutive patients with a diagnosis of intraocular inflammation and who were found to be positive for the presence of HLA-A29 were retrospectively reviewed. Only 7 patients met the criteria for a definite diagnosis of BSCR. Among the other 11 patients, the disease was bilateral in 7 patients and unilateral in 4 patients. A definite diagnosis of the following conditions were found: intraocular and CNS lymphoma in 1 patient, posterior tubercular uveitis with occlusive vasculitis in 1 patient, latent ocular tuberculosis in 1 patient, Fuchs’ uveitis in 1 patient, herpetic panuveitis in 1 patient and HLA-B27 anterior uveitis in another patient. Although BSCR is strongly related to the HLA-A29 phenotype, and its presence confers a relative risk of disease, the definite diagnosis requires specific ocular characteristics. HLA-A29 typing alone is not a diagnostic requirement for the definite diagnosis of BSCR and should only be considered as a supportive finding.Key words: Birdshot chorioretinopathy, Epidemiology, HLA-A29, Uveitis 相似文献
106.
The purpose was to investigate the effect of decentered ablation in myopic corneal refractive surgery by simulation. Wavefront aberrations in a small pupil area (radius: 2 mm) for photopic vision and in a large pupil area (radius: 3 mm) for mesopic vision with simulated refractive surgery were analyzed using Zernike polynomials. Radii of ablation were 3, 2.5 and 2 mm. Decentrations of ablation were 0 mm and 0.5 mm. Change of the surface shape by ablation was considered a perturbation, while Gullstrand’s schematic eye was used as un-perturbed optics. For photopic vision, wavefront aberrations were about the same as with unperturbed optics. For mesopic vision, the results were heavily dependent on the radius of ablation area. When the radius was 3 mm, wavefront aberrations did not increase very much compared to un-perturbed optics. When the radius was smaller than 3 mm, spherical aberration was induced by centered ablations, and coma was also induced by decentered ablations. In conclusion, small ablation areas or subclinical decentrations of ablations could cause serious amounts of wavefront aberrations to the optics of the eye in the simulations. 相似文献
107.
Transpupillary thermotherapy (TTT) has been proposed as a new treatment modality for choroidal neovascularization (CNV). Most studies conducted show decreased exudation due to CNV and reduction of subretinal elevation. Optical coherence tomography (OCT) shows a dynamic sequence of changes early after treatment. Within 1 hour after TTT, OCT shows increased retinal thickness and intraretinal fluid with retinal elevation. One week after treatment, OCT shows decreased subretinal and intraretinal fluid and diminished retinal elevation. OCT can be a valuable method to assess the early effect of TTT. A placebo-controlled, multi-center trial (TTT4CNV) evaluating the long-term efficacy and visual implications of TTT in occult CNV is underway. 相似文献
108.
F Bandello L Berchicci C La Spina M Battaglia Parodi P Iacono 《Ophthalmic research》2012,48(Z1):16-20
Diabetic macular edema (DME) is the most important cause of vision loss in patients with diabetes mellitus. Diabetic retinopathy has a remarkable impact on public health and on the quality of life of diabetic patients and thus requires special consideration. The first line of treatment remains the management of systemic risk factors but is often insufficient in controlling DME and currently, laser retinal photocoagulation is considered the standard of care. However, laser treatment reduces the risk of moderate visual loss by approximately 50% without guaranteeing remarkable effects on visual improvement. For these reasons, new strategies in the treatment of DME have been studied, in particular the use of anti-vascular endothelial growth factor (anti-VEGF) drugs. VEGF is a pluripotent growth factor that acts as a vasopermeability factor and an endothelial cell mitogen. For this reason, it represents an interesting candidate as a therapeutic target for the treatment of DME. The aim of this article is to review the evidence behind the use of anti-VEGF drugs in the treatment of DME. 相似文献
109.
G Querques R Lattanzio L Querques C Del Turco R Forte L Pierro EH Souied F Bandello 《Investigative ophthalmology & visual science》2012,53(10):6017-6024
Purpose. To investigate the changes in macular choroidal thickness in eyes with various stages of diabetic retinopathy, using enhanced depth imaging optical coherence tomography (EDI OCT). Methods. Sixty-three consecutive diabetic patients-who presented without diabetic retinopathy (NDR); with diabetic retinopathy (nonproliferative diabetic retinopathy [NPDR]) and no clinically significant macular edema (CSME-); or with NDPR and clinically significant macular edema (CSME+)-underwent EDI OCT. Twenty-one age- and sex-matched healthy subjects (21 eyes) also underwent EDI OCT. Results. A total of 63 eyes of 63 consecutive diabetic patients (26 female [41.2%]; mean age 65 ± 9 years, range 48-83 years) were included in the analysis. Mean best-corrected visual acuity was 0.13 ± 0.25 LogMAR (range 0-1). Mean CMT was 272.5 ± 16.2 μm in 21 NDR eyes, 294.5 ± 23.5 μm in 21 NPDR/CSME- eyes, and 385.6 ± 75.1 μm in 21 NPDR/CSME+ eyes. There was no difference in mean subfoveal choroidal thickness among each diabetic group (238.4 ± 47.9 μm [NDR], 207.0 ± 55.9 μm [NPDR/CSME-], 190.8 ± 48.4 μm [NPDR/CSME+]; P = 0.23). The mean subfoveal choroidal thickness was significantly reduced in each diabetic group compared with the control group (309.8 ± 58.5 μm, P < 0.001). Conclusions. In diabetic eyes, there is an overall thinning of the choroid on EDI OCT. A decreased choroidal thickness may lead to tissue hypoxia and consequently increase the level of VEGF, resulting in the breakdown of the blood-retinal barrier and development of macular edema. 相似文献
110.
Introini U Torres Gimeno A Scotti F Setaccioli M Giatsidis S Bandello F 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2012,250(9):1283-1292