首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   4193277篇
  免费   340762篇
  国内免费   13787篇
耳鼻咽喉   58554篇
儿科学   134583篇
妇产科学   110268篇
基础医学   649898篇
口腔科学   113306篇
临床医学   380384篇
内科学   755931篇
皮肤病学   105856篇
神经病学   349214篇
特种医学   163438篇
外国民族医学   503篇
外科学   645779篇
综合类   119063篇
现状与发展   23篇
一般理论   2562篇
预防医学   349573篇
眼科学   98562篇
药学   293967篇
  21篇
中国医学   11293篇
肿瘤学   205048篇
  2021年   55635篇
  2020年   35448篇
  2019年   58379篇
  2018年   73584篇
  2017年   55888篇
  2016年   61939篇
  2015年   74944篇
  2014年   109317篇
  2013年   174459篇
  2012年   120458篇
  2011年   125938篇
  2010年   125123篇
  2009年   126482篇
  2008年   112289篇
  2007年   119641篇
  2006年   128426篇
  2005年   123604篇
  2004年   123887篇
  2003年   114302篇
  2002年   103553篇
  2001年   149665篇
  2000年   144517篇
  1999年   134296篇
  1998年   70075篇
  1997年   66197篇
  1996年   64410篇
  1995年   59683篇
  1994年   53772篇
  1993年   50037篇
  1992年   96041篇
  1991年   92636篇
  1990年   89046篇
  1989年   86811篇
  1988年   80014篇
  1987年   78504篇
  1986年   73850篇
  1985年   72974篇
  1984年   61659篇
  1983年   55426篇
  1982年   46016篇
  1981年   43115篇
  1980年   40503篇
  1979年   53098篇
  1978年   44031篇
  1977年   38883篇
  1976年   36264篇
  1975年   36271篇
  1974年   39406篇
  1973年   37631篇
  1972年   35242篇
排序方式: 共有10000条查询结果,搜索用时 78 毫秒
151.
152.
Purpose: To use polymerase chain reaction (PCR) and Goldmann-Witmer coefficient (GWC) calculation to diagnose infectious uveitis.

Methods: Prospective cross-sectional study.

Results: Twenty-seven of 106 patients had positive PCR and/or GWC results on aqueous humor (AH) sampling and 15 of 27 (55.6%) were HIV-positive. Patients with non-anterior uveitis (NAU) were more likely to be HIV+ (p = 0.005). More than 1 possible pathogen was identified in 9 of 27 patients of whom 7 were HIV+. The final clinical diagnosis was discordant with AH findings in 9 of 27 cases. A positive EBV PCR result was associated with a discordant diagnosis (p = 0.001). All cases of herpetic anterior uveitis (42.9% HIV+) tested PCR-/GWC+ while all cases of herpetic NAU tested PCR+/GWC- (83.3% HIV+). All rubella virus cases were PCR+/GWC+.

Conclusion: PCR is useful to diagnose herpetic NAU in HIV+ patients while GWC is useful to diagnose herpetic anterior uveitis.  相似文献   

153.
154.
To determine percent of patients without malignancy and ≤ 40 years of age with high cumulative radiation doses through recurrent CT exams and assess imaging appropriateness. From the cohort of patients who received cumulative effective dose (CED) of ≥ 100 mSv over a 5-year period, a sub-set was identified with non-malignant disease. The top 50 clinical indications leading to multiple CTs were determined. Clinical decision support (CDS) system scores were analyzed using a widely adopted standard of 1–3 (red) as “not usually appropriate,” 4–6 (yellow) “may or may not be appropriate,” and 7–9 (green) “usually appropriate.” Clinicians reviewed patient records to assess compliance with appropriate use criteria (AUC). 9.6% of patients in our series were with non-malignant conditions and 1.4% with age ≤ 40 years. CDS scores (rounded) were 2% red, 38% yellow, 27% green, and 33% unscored CTs. Clinical society guidelines for CT exams, wherever available, were followed in 87.5 to 100% of cases. AUCs were not available for several clinical indications as also referral guidelines for serial CT imaging. More than half of CT exams were unrelated to follow-up of a primary chronic disease. We are faced with a situation wherein patients in age ≤ 40 years require or are thought to require many CT exams over the course of a few years but the radiation risk creates concern. There is a fair number of conditions for which AUC are not available. Suggested solutions include development of CT scanners with lesser radiation dose and further development of appropriateness criteria.  相似文献   
155.
Gattermann  J. 《Der Onkologe》2020,26(11):1010-1018
Die Onkologie - Die Corona-Pandemie hat in den letzten Monaten verdeutlicht, dass das Thema Sterblichkeit trotz erheblicher Fortschritte im Bereich der Hospiz- und Palliativversorgung zu...  相似文献   
156.
Bulletin of Experimental Biology and Medicine - Ammonium, an end-product of catabolism, in low doses can promote adaptation of metabolic pathways in erythrocytes under conditions of extreme...  相似文献   
157.
158.
159.
160.
Introduction: Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype associated with an increased risk of recurrence and cancer-related death. Unlike hormone receptor-positive or HER2-positive breast cancers, there are limited targeted therapies available to treat TNBC and cytotoxic chemotherapy remains the mainstay of treatment. Sacituzumab govitecan (IMMU-132) is an antibody-drug conjugate targeting Trop-2 expressing cells and selectively delivering SN-38, an active metabolite of irinotecan.

Areas covered: This review covers the mechanism of action, safety and efficacy of sacituzumab govitecan in patients with previously treated, metastatic TNBC. Additionally, efficacy data in other epithelial malignancies is included based on a PubMed search for ‘sacituzumab govitecan’ and ‘clinical trial’.

Expert opinion: Sacituzumab govitecan has promising anti-cancer activity in patients with metastatic TNBC previously treated with at least two prior lines of systemic therapy based on a single arm Phase I/II clinical trial. A confirmatory Phase III randomized clinical trial is ongoing. Sacituzumab govitecan has a manageable side effect profile, with the most common adverse events being nausea, neutropenia, and diarrhea. The activity of sacituzumab govitecan likely extends beyond TNBC with promising early efficacy data in many other epithelial cancers, including hormone receptor-positive breast cancer.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号