全文获取类型
收费全文 | 218141篇 |
免费 | 3521篇 |
国内免费 | 146篇 |
专业分类
耳鼻咽喉 | 1566篇 |
儿科学 | 7892篇 |
妇产科学 | 3905篇 |
基础医学 | 22993篇 |
口腔科学 | 1944篇 |
临床医学 | 16243篇 |
内科学 | 40759篇 |
皮肤病学 | 1647篇 |
神经病学 | 20359篇 |
特种医学 | 10122篇 |
外国民族医学 | 32篇 |
外科学 | 34043篇 |
综合类 | 2776篇 |
一般理论 | 8篇 |
预防医学 | 21221篇 |
眼科学 | 3599篇 |
药学 | 12272篇 |
2篇 | |
中国医学 | 757篇 |
肿瘤学 | 19668篇 |
出版年
2023年 | 252篇 |
2022年 | 291篇 |
2021年 | 794篇 |
2020年 | 507篇 |
2019年 | 785篇 |
2018年 | 23037篇 |
2017年 | 18128篇 |
2016年 | 20254篇 |
2015年 | 2005篇 |
2014年 | 1968篇 |
2013年 | 2507篇 |
2012年 | 9923篇 |
2011年 | 23842篇 |
2010年 | 20156篇 |
2009年 | 12646篇 |
2008年 | 21985篇 |
2007年 | 24242篇 |
2006年 | 3056篇 |
2005年 | 4721篇 |
2004年 | 5815篇 |
2003年 | 6556篇 |
2002年 | 4627篇 |
2001年 | 1481篇 |
2000年 | 1677篇 |
1999年 | 1154篇 |
1998年 | 482篇 |
1997年 | 392篇 |
1996年 | 281篇 |
1995年 | 303篇 |
1994年 | 240篇 |
1993年 | 206篇 |
1992年 | 610篇 |
1991年 | 600篇 |
1990年 | 645篇 |
1989年 | 546篇 |
1988年 | 489篇 |
1987年 | 461篇 |
1986年 | 416篇 |
1985年 | 408篇 |
1984年 | 279篇 |
1983年 | 242篇 |
1982年 | 152篇 |
1980年 | 134篇 |
1979年 | 180篇 |
1974年 | 157篇 |
1973年 | 134篇 |
1971年 | 141篇 |
1970年 | 138篇 |
1969年 | 160篇 |
1968年 | 137篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Rigaudière Florence Nasser Hala Pichard-Oumlil Samia Delouvrier Eliane Lopez-Hernandez Elisa Milani Paolo Auvin Stéphane Delanoë Catherine 《Documenta ophthalmologica. Advances in ophthalmology》2021,143(1):99-106
Documenta Ophthalmologica - Neuronal ceroid lipofuscinoses (CLN) are neurodegenerative disorders among the most frequent, inherited as an autosomal recessive trait. Affected patients can present... 相似文献
992.
Ye Y Cheng X Luo HB Liu L Li YB Hou YP 《Journal of assisted reproduction and genetics》2008,25(8):389-394
Purpose The aim of the study was to evaluate the association of CYP1A1 and CYP1B1 polymorphisms with uterine leiomyoma in Chinese
women.
Methods We investigated 100 women with clinically diagnosed uterine leiomyoma and 110 healthy normal subjects from Chinese women.
The genetic distribution of two CYP1A1 polymorphisms at MspI, Ile462Val and four CYP1B1 polymorphisms at Arg48Gly, Ala119Ser,
Leu432Val, Asp449Asp were analyzed by polymerase chain reaction–restriction fragment length polymorphism and DNA sequencing
method.
Results All the SNPs showed polymorphisms in Chinese women. The genotype A/G and the allele G on Ile462Val was significantly different
between uterine leiomyoma patients and controls (P < 0.05).
Conclusion These results suggest that the genotype of CYP1A1 Ile462Val was associated with the increased risk of uterine leiomyomas in
Chinese women.
Capsule This is the first report that demonstrates the polymorphism at Ile462Val of CYP1A1 to be associated with uterine leiomyoma
in Chinese women. 相似文献
993.
994.
Fanny Varenne Ali Makky Mireille Gaucher-Delmas Frédéric Violleau Christine Vauthier 《Pharmaceutical research》2016,33(5):1220-1234
Purpose
Evaluation of particle size distribution (PSD) of multimodal dispersion of nanoparticles is a difficult task due to inherent limitations of size measurement methods. The present work reports the evaluation of PSD of a dispersion of poly(isobutylcyanoacrylate) nanoparticles decorated with dextran known as multimodal and developed as nanomedecine.Methods
The nine methods used were classified as batch particle i.e. Static Light Scattering (SLS) and Dynamic Light Scattering (DLS), single particle i.e. Electron Microscopy (EM), Atomic Force Microscopy (AFM), Tunable Resistive Pulse Sensing (TRPS) and Nanoparticle Tracking Analysis (NTA) and separative particle i.e. Asymmetrical Flow Field-Flow Fractionation coupled with DLS (AsFlFFF) size measurement methods.Results
The multimodal dispersion was identified using AFM, TRPS and NTA and results were consistent with those provided with the method based on a separation step prior to on-line size measurements. None of the light scattering batch methods could reveal the complexity of the PSD of the dispersion.Conclusions
Difference between PSD obtained from all size measurement methods tested suggested that study of the PSD of multimodal dispersion required to analyze samples by at least one of the single size particle measurement method or a method that uses a separation step prior PSD measurement.995.
Rationale and objective Although many contingencies operating in the natural environment include continuous dimensions of responses and reinforcers,
previous studies of drug self-administration have almost exclusively used discrete dimensions of responses (e.g., a lever
press) and reinforcers (e.g., 1.0 mg/kg/injection cocaine). Therefore, the present study provides an initial examination under
experimental conditions with both responses and reinforcers measured along continuous dimensions.
Materials and methods Cocaine-maintained responding was studied in rats under a novel, hold-down schedule of reinforcement wherein the duration
of the response was directly related to the magnitude of the reinforcer. These conditions were established by activating the
syringe pump when the lever was pressed down and turning the pump off when the lever was released. The concentration of cocaine
available in the syringe was varied across sessions.
Results Cocaine self-administration was readily maintained under these conditions and remained stable across sessions. Responding
was concentration dependent, with the number of responses and total duration of the response inversely related to concentration,
and overall session intake of cocaine was stable across concentrations. In general, the duration of the responses were less
than 0.5 s and did not vary as a function of concentration.
Conclusions Stability of responding under these schedule conditions was acquired quickly. This schedule of reinforcement may be useful
for comparing across drug classes, can be extended for use with other types of responses and reinforcers, and may be more
representative of the natural world where response-reinforcer contingencies are more likely to be experienced along continuous,
rather than discrete, dimensions.
Drake Morgan and Yu Liu contributed equally to this publication. 相似文献
996.
Marie-Laure Paillère Martinot Jean-Luc Martinot Damien Ringuenet André Galinowski Thierry Gallarda Frank Bellivier Jean-Pascal Lefaucheur Hervé Lemaitre Eric Artiges 《Neuropsychopharmacology》2011,36(13):2710-2719
Neuroimaging studies of patients with treatment-resistant depression (TRD) have reported abnormalities in the frontal and temporal regions. We sought to determine whether metabolism in these regions might be related to response to repetitive transcranial magnetic stimulation (TMS) in patients with TRD. Magnetic resonance images and baseline resting-state cerebral glucose uptake index (gluMI) obtained using 18F-fluorodeoxyglucose positron emission tomography were analyzed in TRD patients who had participated in a double-blind, randomized, sham-controlled trial of prefrontal 10 Hz TMS. Among the patients randomized to active TMS, 17 responders, defined as having 50% depression score decrease, and 14 nonresponders were investigated for prestimulation glucose metabolism and compared with 39 healthy subjects using a voxel-based analysis. In nonresponders relative to responders, gluMI was lower in left lateral orbitofrontal cortex (OFC), and higher in left amygdala and uncinate fasciculus. OFC and amygdala gluMI negatively correlated in nonresponders, positively correlated in responders, and did not correlate in healthy subjects. Relative to healthy subjects, both responders and nonresponders displayed lower gluMI in right dorsolateral prefrontal (DLPFC), right anterior cingulate (ACC), and left ventrolateral prefrontal cortices. Additionally, nonresponders had lower gluMI in left DLPFC, ACC, left and right insula, and higher gluMI in left amygdala and uncus. Hypometabolisms were partly explained by gray matter reductions, whereas hypermetabolisms were unrelated to structural changes. The findings suggest that different patterns of frontal–temporal–limbic abnormalities may distinguish responders and nonresponders to prefrontal magnetic stimulation. Both preserved OFC volume and amygdala metabolism might precondition response to TMS. 相似文献
997.
目的:研究不同处理方法对卵白蛋白(Ovum Albumin,OVA)变应性鼻炎小鼠模型腹腔肥大细胞脱颗粒的影响。方法:将60只雌性小鼠随机分为5组,每组12只,分别按不同方法处理后分离各组小鼠的腹腔肥大细胞,中性红染色后计算腹腔肥大细胞脱颗粒率。结果:正常对照组、OVA变应性鼻炎组、穴位敷贴组、激素对照组、磷酸盐缓冲液(Phosphate Buffer Saline,PBS)阴性对照组小鼠腹腔肥大细胞脱颗粒率分别为(15±6)%、(53±11)%、(37±13)%、(31±15)%、(47±14)%。OVA变应性鼻炎小鼠的腹腔肥大细胞有明显的脱颗粒现象:与OVA变应性鼻炎小鼠相比,穴位敷贴组及激素对照组小鼠的腹腔肥大细胞脱颗粒现象显著减轻;PBS对照组小鼠的腹腔肥大细胞脱颗粒现象没有明显变化。结论:推测穴位敷贴抗过敏机制为稳定肥大细胞膜,抑制肥大细胞脱颗粒,减少致炎介质产生。 相似文献
998.
目的:观察推拿在全髋关节置换术后康复治疗中的临床疗效。方法:将60例患者随机分成治疗组和对照组。治疗组30例进行推拿结合康复治疗,对照组30例进行单纯康复治疗。两组均治疗2星期。分别观察两组患者术后7天、术后2星期、术后6星期的改良人工髋关节Harris量表及汉密尔顿焦虑量表(Hamilton Anxiety Rating Scale,HAMA)。结果:Harris量表评分总分,两组组内患者不同时间点多重比较差异有统计学意义(P〈0.05);术后1天、术后7天及术后6星期两组间比较,差畀均无统计学意义(A,0.05);术后2星期两组间比较差异有统计学意义(P〈0.05)。HAMA量表两组组内患者不同时间点多重比较差异有统计学意义(P〈0.05);术后1天两纽间评分无显著性差异(P〉0.05);术后7天、术后2星期、术后6星期两组间评分均有显著性差异(P〈0.05)。结论:单位时间内,推拿结合康复治疗对全髋关节置换术后患者的疼痛、关节活动范围及焦虑等方面的改善作用优于单纯康复治疗。 相似文献
999.
傅鸿亮 《针灸推拿医学(英文版)》2004,2(3):47-50
先应用改良斜扳法和旋转定位扳法对腰椎间盘突出症患者进行手法复位,然后取水沟和委中为主穴,进行针剌治疗.共治疗97例患者,治愈58例,好转35例,无效4例,总有效率95.9%. 相似文献
1000.