全文获取类型
收费全文 | 32061篇 |
免费 | 2006篇 |
国内免费 | 152篇 |
专业分类
耳鼻咽喉 | 321篇 |
儿科学 | 781篇 |
妇产科学 | 799篇 |
基础医学 | 4740篇 |
口腔科学 | 1882篇 |
临床医学 | 2716篇 |
内科学 | 7171篇 |
皮肤病学 | 981篇 |
神经病学 | 2790篇 |
特种医学 | 529篇 |
外科学 | 2591篇 |
综合类 | 128篇 |
一般理论 | 21篇 |
预防医学 | 3649篇 |
眼科学 | 523篇 |
药学 | 2553篇 |
中国医学 | 192篇 |
肿瘤学 | 1852篇 |
出版年
2024年 | 42篇 |
2023年 | 381篇 |
2022年 | 869篇 |
2021年 | 1532篇 |
2020年 | 868篇 |
2019年 | 1249篇 |
2018年 | 1515篇 |
2017年 | 1009篇 |
2016年 | 961篇 |
2015年 | 1196篇 |
2014年 | 1570篇 |
2013年 | 1934篇 |
2012年 | 2956篇 |
2011年 | 3115篇 |
2010年 | 1545篇 |
2009年 | 1298篇 |
2008年 | 2140篇 |
2007年 | 2078篇 |
2006年 | 1801篇 |
2005年 | 1579篇 |
2004年 | 1369篇 |
2003年 | 1150篇 |
2002年 | 999篇 |
2001年 | 108篇 |
2000年 | 62篇 |
1999年 | 92篇 |
1998年 | 134篇 |
1997年 | 128篇 |
1996年 | 82篇 |
1995年 | 64篇 |
1994年 | 66篇 |
1993年 | 48篇 |
1992年 | 44篇 |
1991年 | 29篇 |
1990年 | 23篇 |
1989年 | 20篇 |
1988年 | 16篇 |
1987年 | 14篇 |
1986年 | 13篇 |
1985年 | 12篇 |
1984年 | 12篇 |
1983年 | 12篇 |
1982年 | 15篇 |
1981年 | 9篇 |
1980年 | 13篇 |
1978年 | 6篇 |
1976年 | 6篇 |
1975年 | 7篇 |
1973年 | 5篇 |
1972年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
991.
RP Soares AC Torrecilhas RR Assis MN Rocha FA Moura e Castro GF Freitas SM Murta SL Santos AF Marques IC Almeida AJ Romanha 《The American journal of tropical medicine and hygiene》2012,87(1):87-96
The glycosylphosphatidylinositol (GPI)-anchored mucins of Trypanosoma cruzi trypomastigotes play an important immunomodulatory role during the course of Chagas disease. Here, some biological activities of tGPI-mucins from four T. cruzi isolates, including benznidazole-susceptible (BZS-Y), benznidazole-resistant (BZR-Y), CL, and Colombiana, were evaluated. GPI-mucins were able to differentially trigger the production of interleukin-12 and nitric oxide in BALB/c macrophages and modulate LLC-MK2 cell invasion. The significance of these variations was assessed after analysis of the terminal α-galactosyl residues. Enzymatic treatment with α-galactosidase indicated a differential expression of O-linked α-galactosyl residues among the strains, with higher expression of this sugar in BZS-Y and BZR-Y T. cruzi populations followed by Colombiana and CL. Unweighted pair group method analysis of the carbohydrate anchor profile and biological parameters allowed the clustering of two groups. One group includes Y and CL strains (T. cruzi II and VI), and the other group is represented by Colombiana strain (T. cruzi I). 相似文献
992.
Chen-Xu M Topless R McKinney C Merriman ME Phipps-Green A Dalbeth N Gow PJ Harrison AA Highton J Jones PB Nissen M Smith MD van Rij A Jones GT Rodriguez-Rodriguez L Fernandez-Gutierrez B Teruel M Balsa A Pascual-Salcedo D Ortiz AM Gonzalez-Gay MA Steer S Maehlen M Lie B Wordsworth BP Stamp LK Martin J Merriman TR 《Annals of the rheumatic diseases》2012,71(1):155-157
993.
994.
de Oliveira JA do Amaral Escada AL Alves Rezende MC Mathor MB Alves Claro AP 《Clinical oral implants research》2012,23(4):511-514
Objective: The purpose of the present study was to evaluate the influence of radiation in osseointegrated dental implants installed in tibiae of rats. Material and methods: Screw‐shaped implants (2.5 mm diameter by 3.5 mm length) were custom made from commercially pure titanium bars. Titanium implants were blasted and sterilized before implantation. Animals were divided into two groups of 12 animals each and the rats were not paired after the groups' formation. The experimental group (group 1) received external irradiation 4 weeks after surgery while in the control group (group 2) animals were kept free of radiation. The shear strength required to detach the implant from bone was measured by push‐out testing and osseointegration was histologically evaluated. Results: Results showed that the compressive strength of irradiated implants (33.49 MPa) was significantly lower than the compressive strength of non‐irradiated implants (48.05 MPa). Conclusions: We concluded that the mechanical strength bonding between implants and host tissues decreased after irradiation. To cite this article: Oliveira JAG, Escada ALA, Alves Rezende MCR, Mathor MB, Alves Claro APR. Analysis of the effects of irradiation in osseointegrated dental implants.Clin. Oral Impl. Res. 23 , 2012 511–514.doi: 10.1111/j.1600‐0501.2010.02149.x 相似文献
995.
Muñoz F Del Río N Sóñora C Tiscornia I Marco A Hernández A 《European journal of oral sciences》2012,120(2):104-112
Enamel defects in the permanent teeth of patients with coeliac disease (CD) are often reported as an atypical manifestation, sometimes being suggestive of an undiagnosed atypical disease. We proposed to explore the pathogenesis of these oral defects, which are poorly studied. Sequence analyses of proteins from gluten (gliadins) and of proline-rich enamel proteins (amelogenin and ameloblastin) suggested the presence of common antigenic motifs. Therefore, we analyzed, by ELISA and western blotting, the reactivity of sera from patients with CD against gliadin and enamel-derived peptides. Correlation analyses between the levels of specific antibodies against gliadin and enamel derived peptides and inhibition experiments confirmed the presence of cross-reactive antibodies. Immunoblot analysis revealed that the most prominent component in enamel matrix derivative (of approximately 18.6 kDa), identified by an amelogenin-specific antibody, is recognized by sera from patients with CD; in addition, several fractions of pure gliadin were recognized by amelogenin-specific antibody. In agreement, sera from mice immunized with enamel matrix-derived proteins generated antibodies that recognized a peptide (of approximately 21.2 kDa) derived from gliadin. In conclusion, antibodies against gliadin generated in patients with CD can react in vitro with a major enamel protein. The involvement of anti-gliadin serum in the pathogenesis of enamel defects in children with untreated CD can be hypothesized on the basis of these novel results. 相似文献
996.
Balaban R Aguiar CM da Silva Araújo AC Dias Filho EB 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2012,22(4):286-291
International Journal of Paediatric Dentistry 2012; 22: 286–291 Background. In dentistry, clinical practice is directed towards attitudes that promote oral health and the paediatricians occupy a privileged position in this process. Aim. To assess the knowledge and attitudes of paediatricians in relation to the oral health of their patients. Design. A cross‐sectional study was carried out at the Institute of Integrative Medicine Professor Fernando Figueira, Recife, Brazil. A total of 182 paediatricians participated by filling out a questionnaire. Results. A total of 63.9% believed the first visit to the dentist should occur before the child completes 1 year of life. Moreover, 67.8% considered their knowledge on oral health to be insufficient. Approximately 78% of the paediatricians diagnosed caries through an analysis of cavities. Only 29.9% always recommended fluoride dentifrice. The term ‘fluorosis’ was unknown by 48.3% of the respondents. Concerning pacifiers, 32.6% did not allow it and 66.9% did not either recommend it or restrict it. A total of 83.4% classified the oral health content in their medical education as either nonexistent or deficient; this figure remained high (72.4%) in relation to residency. Conclusions. It is important to develop oral health information programmes to paediatricians. Information on oral health should be included in medical curricula and residency. 相似文献
997.
998.
D Suzuki AP Bassi HJ Lee PR Alcântara IM de Sartori ER Luvizuto EF Faco F Faot 《The Journal of craniofacial surgery》2012,23(4):e347-e349
The aims of this article were to describe the surgical technique of the inferior alveolar nerve lateralization followed by implant installation by means of a clinical report and also to discuss the importance of an adequate surgical and prosthetic planning for atrophic posterior mandible rehabilitation. 相似文献
999.
da Silva LC Oliveira AC dos Santos JA Santos Tde S 《Journal of cranio-maxillo-facial surgery》2012,40(7):604-607
ObjectiveThe aim of this study was to analyze the criteria employed for the requesting of preoperative tests among maxillofacial surgeons.Materials and methodsThirty maxillofacial surgeons working in Aracaju (Brazil) received a questionnaire to fill out. The study inquired about the practice of requesting preoperative tests for healthy patients scheduled to undergo elective surgery.ResultsMost of the surgeons interviewed requested tests that are not recommended for the case in question. The highest frequency of requests was a complete blood count, coagulation test, blood glucose test and chest radiograph.ConclusionThe absence of strict rules for the requesting of preoperative tests causes uncertainty and a lack of criteria regarding pre-surgical conduct. It was not possible to clearly define the criteria used by surgeons for requesting such tests, as the clinical characteristics of the hypothetical case presented suggest a smaller number of tests. 相似文献
1000.
Tolentino ES Centurion BS Tjioe KC Casaroto AR Tobouti PL Frederigue Junior U Lara VS Damante JH Sant'ana E Gonçales ES 《Oral surgery, oral medicine, oral pathology and oral radiology》2012,113(6):e40-e45
Juvenile ossifying fibroma (JOF) is a rare fibro-osseous neoplasm, defined as a variant of the ossifying fibroma that arises within the craniofacial bones. Two subgroups, juvenile psammomatoid ossifying fibroma (PsJOF) and juvenile trabecular ossifying fibroma, have been delineated by their histology. PsJOF occurs predominantly in the sinonasal and orbital bones. This work reports on 2 cases of extensive PsJOF in the body of the right mandible as well as reviews the literature regarding the radiographic and histologic features, treatment, and prognosis of PsJOF of the jaws. 相似文献