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41.
Purpose
The aim of this study was to identify the dominant factors affecting the stability of nanoemulsions, using artificial neural networks (ANNs). 相似文献42.
Luísa S.M. Mendonça Rhianon Perrott-Reynolds Roy Schwartz Haifa A. Madi Nicola Cronbach Isaac Gendelman Alyson Muldrew Finnian Bannon Konstantinos Balaskas Chui Ming Gemmy Cheung Amani Fawzi Daniela Ferrara K. Bailey Freund James Fujimoto Marion R. Munk Giuseppe Querques Ramiro Ribeiro Philip J. Rosenfeld Nadia K. Waheed 《Ophthalmology》2021,128(7):1109-1112
43.
Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain. 总被引:11,自引:0,他引:11
Asser I Ghoneim Ashraf B Abdel-Naim Amani E Khalifa Ezzeddin S El-Denshary 《Pharmacological research》2002,46(3):273-279
Oxidative stress is believed to be implicated in the pathogenesis of postischaemic cerebral injury. Many antioxidants were shown to be neuroprotective in experimental models of cerebral ischaemia/reperfusion (I/R). The present study was designed to investigate the potential protective effects of curcumin (CUR) against I/R insult in rat forebrain. The model adopted was that of surgically-induced forebrain ischaemia, performed by means of bilateral common carotid artery occlusion (BCCAO) for 1 h, followed by reperfusion for another 1h. The effects of a single i.p. dose of CUR (50, 100 or 200 mg kg(-1)), administered 0.5 h after the onset of ischaemia, were investigated by assessing oxidative stress-related biochemical parameters in rat forebrain. CUR, at the highest dose level (200 mg kg(-1)), decreased the I/R-induced elevated xanthine oxidase (XO) activity, superoxide anion (O(2)*(-)) production, malondialdehyde (MDA) level and glutathione peroxidase (GPx), superoxide dismutase (SOD), and lactate dehydrogenase (LDH) activities. On the other hand, CUR did not affect the declined reduced glutathione (GSH) content due to I/R insult. Worth mentioning is that the activity of catalase (CAT) did not change in response to either I/R insult or drug treatment. In conclusion, CUR was found to protect rat forebrain against I/R insult. These protective effects may be attributed to its antioxidant properties and/or its inhibitory effects on xanthine dehydrogenase/xanthine oxidase (XD/XO) conversion and resultant O(2)*(-) production. 相似文献
44.
Dorsaf Toumi Amani Mankai Ramla Belhadj Leila Ghedira-Besbes Moncef Jeddi Ibtissem Ghedira 《Clinical chemistry and laboratory medicine》2008,46(3):350-353
BACKGROUND: The aim of our study was to evaluate, retrospectively, the frequency of anti-thyroid antibodies (ATA) in coeliac disease (CD) patients. METHODS: ELISA was used to determine the frequency of anti-thyroid stimulating hormone receptor antibodies, thyroperoxidase antibodies and thyroglobulin antibodies in sera of 104 adult patients with CD. Patients were divided into three groups: group I, 56 untreated patients; group II, 21 patients on a strict gluten-free diet (GFD); and group III, 27 patients who did not comply with a GFD. Sera of 189 healthy blood donors served as controls. RESULTS: Out of 104 patients with CD, five (4.8%) had ATA. The frequency of ATA found in the control group (1.6%) was not significantly different from that found in all CD patients. However, the frequency of ATA in CD patients on a GFD was significantly higher than that found in the control group (8.3% vs. 1.6%, p=0.03). The frequency of ATA in groups I, II and III was 1.8%, 9.5% and 7.4%, respectively. CONCLUSIONS: ATA were found in CD patients even on a GFD. 相似文献
45.
46.
Holder-Dixon Amani R. Adams Olivia R. Cobb Tianna L. Goldberg Alison J. Fikslin Rachel A. Reinka Mora A. Gesselman Amanda N. Price Devon M. 《Journal of behavioral medicine》2022,45(5):760-770
Journal of Behavioral Medicine - Medical avoidance is common among U.S. adults, and may be emphasized among members of marginalized communities due to discrimination concerns. In the current study,... 相似文献
47.
Mohammad Ibrahim Khalil Gouri Rani Banik Sarab Mansoor Amani S Alqahtani Harunor Rashid 《World Journal of Clinical Cases》2021,9(10):2170-2180
The exact risk association of coronavirus disease 2019 (COVID-19) for surgeons is not quantified which may be affected by their risk of exposure and individual factors. The objective of this review is to quantify the risk of COVID-19 among surgeons, and explore whether facemask can minimise the risk of COVID-19 among surgeons. A systematised review was carried out by searching MEDLINE to locate items on severe acute respiratory syndrome coronavirus 2 or COVID-19 in relation to health care workers (HCWs) especially those work in surgical specialities including surgical nurses and intensivists. Additionally, systematic reviews that assessed the effectiveness of facemask against viral respiratory infections, including COVID-19, among HCWs were identified. Data from identified articles were abstracted, synthesised and summarised. Fourteen primary studies that provided data on severe acute respiratory syndrome coronavirus 2 infection or experience among surgeons and 11 systematic reviews that provided evidence of the effectiveness of facemask (and other personal protective equipment) were summarised. Although the risk of COVID-19 could not be quantified precisely among surgeons, about 14% of HCWs including surgeons had COVID-19, there could be variations depending on settings. Facemask was found to be somewhat protective against COVID-19, but the HCWs’ compliance was highly variable ranging from zero to 100%. Echoing surgical societies’ guidelines we continue to recommend facemask use among surgeons to prevent COVID-19. 相似文献
48.
The aim of this work was to incorporate a hydrophobic compound benzophenone (BP) into core-shell nanoparticles (NPs) and to study its release. The core of these NPs is based on polylactic acid (PLA) and serves as a nanocontainer to accommodate BP. The shell is constituted of a β-cyclodextrin polymer (Poly-β-CD) which ensures the control of BP release through non-covalent host-guest interactions. Studies were focused on the preparation, physico-chemical analysis of the BP-loaded NPs and on the elucidation of the release mechanisms. The main features which are the slow kinetics, the dilution-induced release and the total release of encapsulated BP are in good agreement with a mechanism mainly controlled by diffusion of BP and by its binding with the β-CDs cavities present at the surface of NPs. 相似文献
49.
El-Agroudy AE El-Dahshan KF Mahmoud K Ismail AM El-Baz M Shokeir AA Ghoneim MA 《Clinical and experimental nephrology》2009,13(1):66-72
Background/aim This retrospective study was conducted to assess the efficacy and safety of immunosuppression conversion on progression of
chronic allograft nephropathy (CAN).
Methods One-hundred and seventy-four cyclosporin (CsA)-treated renal transplant recipients were studied. Patients were included if
they had a biopsy-proven CAN (mild to moderate) with serum creatinine ≤3.5 mg/dL. Patient treatment was switched to either:
(A) MMF/reduced dose CsA (MMF for azathioprine (Aza); n = 132); or (B) Aza/Tac for CsA (n = 42). Patient records were checked for graft function and survival, and for co-morbidities after conversion.
Results Mean follow-up before conversion was 52.2 ± 31.1 and 47.9 ± 27.4 months for groups A and B, respectively. There was significant
deterioration of graft function in group B after five years (P < 0.5). Ten-year actuarial graft survival was 38% in group A and 19% in group B (P = 0.04). Nine patients (five patients and four patients in groups A and B, respectively) started dialysis within 12 months.
Tacrolimus-treated patients had a lower insignificant incidence of hyperlipidemia (P = 0.05), but a significantly higher incidence of diabetes mellitus (P = 0.04).There was no significant change or difference in blood pressure between groups.
Conclusions Our results suggest that in patients with CAN and deteriorating allograft function, CsA minimization and addition of MMF achieved
favorable efficacies in retarding the decline of graft function. Further prospective studies with larger cohorts are needed
for validation. 相似文献
50.
Osama Gheith Ehab Wafa Nabil Hassan Amani Mostafa Hussein A. Sheashaa Khaled Mahmoud Ahmed Shokeir Mohamed A. Ghoneim 《Clinical and experimental nephrology》2009,13(4):361-366
Background/Aims Posttransplantation anemia (PTA) frequently occurs. We aimed to assess the prevalence of anemia at 6 months of transplantation
in patients under different protocols of immunosuppression, and to determine the impact of anemia on long-term patient and
graft survival.
Methods We included 832 renal transplant recipients who were categorized at 6 months according to hemoglobin (Hb) level into two groups:
the first group, with Hb >13 g/dl in males and >12 g/dl in females (group I, 385 cases); and the second group, with Hb <13 g/dl
in males and <12 g/dl in females (group II, 447 cases). We compared the two groups regarding posttransplant complications
as well as patient and graft survival.
Results Although there was no significant difference between the two groups regarding acute rejection episodes, chronic allograft
nephropathy was significantly higher in the anemic group. Other posttransplant medical complications were comparable in both
groups. Graft survival was significantly higher in the nonanemic group. However, no difference in patient survival was detected.
Conclusion From this study, we can conclude that prevalence of PTA is high, especially in females and those receiving calcineurine inhibitors
(CNI) and mycophenolate mofetil (MMF), and that it was associated with poorer graft outcome but with no effect on patient
survival. 相似文献