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Amani Al-Rawashdeh Violet Kasabri Nailya Bulatova Amal Akour Ayman Zayed Munther Momani Nahla Khawaja Haider Bustanji Dana Hyasat 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2017,11(1):59-67
Background
Oxytocin (OXT) is a neurohypophyseal hormone that has been recently shown to possess a number of beneficial effects in diabetes and obesity. Betatrophin is a protein expressed in fat and liver that regulates lipid metabolism and promotes pancreatic β-cell proliferation. It is not investigated yet whether OXT and betatrophin levels correlate in metabolic syndrome (MS) or diabetes patients.Methods
The aim was to assess correlations between plasma betatrophin and OXT levels in MS-diabetic or prediabetic (N = 89) as compared to MS-non-diabetic (N = 69) patients. Competitive binding ELISA was used to evaluate betatrophin and OXT plasma concentrations. Correlations of the above biomarkers and patient clinical characteristics were also detected.Results
As compared to the control MS participants (0.32 ± 0.25 ng/mL); betatrophin plasma levels were increased (P < 0.001) in the MS-pre/T2DM patients (1.23 ± 0.68 ng/mL). On the contrary, OXT concentrations were decreased (P < 0.001) in the MS-pre/T2DM patients (1222.46 ± 514.55 pg/mL) as compared to the MS control subjects (2323.42 ± 848.68 pg/mL). OXT concentration correlated negatively (r = ?0.492, P < 0.001), while HbA1c and FPG correlated positively with betatrophin plasma levels (P < 0.001), but were inversely correlated with OXT levels (P < 0.001) in the total sample.Conclusion
Betatrophin levels are increased, while OXT levels are decreased in MS-pre/T2DM. We found an inverse correlation between the levels of the two biomarkers in addition to correlation between their levels and the degree of glycemic control. 相似文献104.
Baek SK Makkouk AR Krasieva T Sun CH Madsen SJ Hirschberg H 《Journal of neuro-oncology》2011,104(2):439-448
One of the major factors that limits the treatment effectiveness for gliomas is the presence of the blood–brain barrier (BBB)
which protects infiltrating glioma cells from the effects of anti-cancer agents. Circulating monocytes/macrophages (Ma) have
a natural ability to traverse the intact and compromised BBB and loaded with anti cancer agents could be used as vectors to
target tumors and surrounding tumor infiltrated tissue. Nanoshells (NS) are composed of a dielectric core (silica) coated
with an ultrathin gold layer which converts absorbed near-infrared light (NIR) to heat with an extremely high efficacy and
stability. We have investigated the effects of exposure to laser NIR on multicell human glioma spheroids infiltrated with
empty (containing no nanoshells) or nanoshell loaded macrophages. Our results demonstrated that; (1) macrophages could efficiently
take up bare or coated (PEGylated) gold NS: (2) NS loaded macrophages infiltrated into glioma spheroids to the same or, in
some cases, to a greater degree than empty Ma; (3) NIR laser irradiation of spheroids incorporating NS loaded macrophages
resulted in complete growth inhibition in an irradiance dependent manner, and (4) spheroids infiltrated with empty macrophages
had growth curves identical to untreated control cultures. The results of this study provide proof of concept for the use
of macrophages as a delivery vector of NS into gliomas for photothermal ablation and open the possibility of developing such
regimens for patient treatment. 相似文献
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Amani S. Awaad Al‐Jaber A. Nabilah Mohamed E. Zain 《Phytotherapy research : PTR》2012,26(12):1872-1877
Two new butyrolactone I derivatives: 3‐[3‐hydroxy‐4‐(3‐methyl‐but‐2‐enyl)‐phenyl]‐5‐(?4‐hydroxybenzyl)‐4‐methyl‐dihydrofuran‐2(3H)‐one (1) and (Z)‐3‐[3‐hydroxy‐4‐(3‐methyl‐but‐2‐enyl)‐phenyl]‐5‐(?4‐hydroxybenzylidene)‐4‐methyl‐dihydrofuran‐2(3H)‐one (2), in addition to the previously described (S)‐methyl‐4‐hydroxy‐2‐[4‐hydroxy‐3‐(3‐methyl‐but‐2‐enyl)‐benzyl]‐3‐(4‐hydroxy‐phenyl)‐5‐oxo‐2,5‐dihydro‐furan‐2‐carboxylic acid methyl ester (3), were identified from a strain of Aspergillus terreus Thom (Trichocomaceae) isolated from desert soil. The antifungal activities of both intra‐ and extracellular metabolites of A. terreus grown on yeast extract sucrose and malt extract media were determined. Only the secondary metabolites of A. terreus grown on yeast extract sucrose medium were active against Aspergillus fumigatus RCMB 002008. The antifungal activity of A. terreus was attributed to the presence of the compounds (1) and (2), whose minimum inhibitory concentrations (MIC) against A. fumigatus were found to be 32.00 and 16.00 µg/mL respectively. Structure elucidation was carried out using UV spectrometry, electrospray ionization mass spectrometry (ESIMS), high resolution electron impact (HREIMS) spectrometry, 1H‐ and 13 C‐NMR, proton–proton correlation spectroscopy (1H–1H Cosy), distortionless enhancement by polarization transfer (DEPT), heteronuclear single quantum coherence (HSQC) and heteronuclear multiple bond correlations (HMBC) spectroscopy. Copyright © 2012 John Wiley & Sons, Ltd. 相似文献
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From 2000 to 2007, 11,793 cancer patients received treatment in Kuwait. Non-Kuwaitis accounted for 6,016 (51%) patients. They came from 68 countries, mainly from the World Health Organization Eastern Mediterranean (59%) and South-East Asian (20%) regions. The majority (69%) was from low- and low-middle income countries. Thirty-seven percent were from non-Arabic speaking countries. To provide culturally-competent care for expatriate patients, there is a need to explore the impact of their ethnic, sociocultural, economic, language diversity, and expatriation-related stressors on different aspects of cancer care. 相似文献
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Amani Mubarak Eric Spierings Victorien M Wolters Henny G Otten Fiebo JW ten Kate Roderick HJ Houwen 《World journal of gastroenterology : WJG》2013,19(41):7114-7120
AIM:To investigate whether celiac disease(CD)patients with tissue-transglutaminase antibody(tTGA)≥100 U/mL are different from patients with lower tTGA levels.METHODS:Biopsy-proven(MarshⅢ)pediatric CD patients(n=116)were prospectively included between March 2009 and October 2012.The biopsies were evaluated by a single pathologist who was blinded to all of the patients’clinical data.The patients were distributed into 2 groups according to their tTGA level,which was measured using enzyme-linked immunoassay:tTGA≥100 U/mL and Ttga<100 U/mL.The patients’characteristics,symptoms,human leukocyte antigen(HLA)genotype and degree of histological involvement were compared between the 2 groups.RESULTS:A total of 34(29.3%)children had tTGA values<100 U/mL and 82(70.7%)tTGA levels of≥100 U/mL.Patients with high tTGA levels had lower average body weight-for-height standard deviation scores(SDS)than did patients with tTGA<100 U/mL(-0.20±1.19 SDS vs 0.23±1.03 SDS,P=0.025).In the low tTGA group,gastrointestinal symptoms were more common(97.1%vs 75.6%,P=0.006).More specifically,abdominal pain(76.5%vs 51.2%;P=0.012)and nausea(17.6%vs 3.7%,P=0.018)were more frequent among patients with low tTGA.In contrast,patients with solely extraintestinal manifestations were only present in the high tTGA group(18.3%,P=0.005).These patients more commonly presented with aphthous stomatitis(15.9%vs 0.0%,P=0.010)and anemia(32.9%vs 11.8%,P=0.019).In addition,when evaluating the number of CD-associated HLA-DQ heterodimers(HLA-DQ2.5,HLA-DQ2.2 and HLA-DQ8),patients with low tTGA levels more commonly had only1 disease-associated heterodimer(61.8%vs 31.7%,P=0.005),while patients with high tTGA more commonly had multiple heterodimers.Finally,patients with tTGA≥100 U/mL more often had a MarshⅢc lesion(73.2%vs 20.6%,P≤0.001)while in patients with low tTGA patchy lesions were more common(42.4%vs6.8%,P≤0.001).CONCLUSION:Patients with tTGA≥100 U/mL show several signs of more advanced disease.They also carry a larger number of CD 相似文献