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Aljoscha S. Neubauer Martin Thiel Siegfried Priglinger Christos Chryssafis Claudia Alge Ulrich Welge-Lüssen Anselm Kampik 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2006,244(3):342-351
Purpose To evaluate a novel technique for three-dimensional mapping of the retinal pigment epithelium (RPE) layer in patients with
subfoveal choroidal neovascularization (CNV) due to age-related macular degeneration.
Methods Scanning with a recent generation retinal thickness analyzer (RTA) was performed in consecutive patients undergoing fluorescein
angiography. From a 3×3mm area centered on the fovea, three-dimensional area maps of the RPE level were calculated by external
spreadsheet software. Included were 18 eyes with classic CNV, 18 eyes with occult CNV and 18 eyes from age-matched normal
subjects. Repeatability was assessed by measuring 17 eyes with CNV 3 times. In ten additional patients, RTA imaging results
were compared with cross-sections obtained by optical coherence tomography.
Results By both methods, distinctive changes in RPE level maps were observed in classic and occult CNV. In classic CNV with the lesion
extending over the RPE, only focal irregularities in the anteriorly displaced RPE surface were observed. In contrast, mapping
of occult CNV showed a more irregular displacement of the RPE layer. The RPE map standard deviation indicating surface irregularity
differed statistically significantly between the groups, with coefficients of variance of 5.9% for controls, 6.1% for classic
and 8.8% for occult CNV (P<0.001). Regarding repeatability, RPE level maps showed 1.2% coefficient of variance and an intra-class correlation coefficient
of 0.87 for triplicate measurements in CNV patients.
Conclusions Topographic mapping of CNV lesions offers a fast, reproducible method for obtaining three-dimensional morphometric information
on the RPE level and to quantify changes. 相似文献
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HU Jie胡杰 JIANG Cheng-chuan江澄川 Ho-Keung Ng吴浩强 Jesse CS Pang 彭颂先 Carol YK Tong唐婉君 CHEN Shang-qun 陈商群 《中国癌症研究》2002,14(3):183-186
Glioblastoma multiforme (GBM), the most malignant type of glioma, is the most common primary brainneoplasm. Although comprehensive therapeutic measures are applied, the prognosis of GBM remains dismal with a median post-treatment survival of less than one year.Modern molecular genetics has demonstrated thatabnormal alterations of tumor suppressor genes (TSGs) and oncogenes are the major mechanisms responsible for the initiation and progression of this malignant tumor.Identifying of related… 相似文献
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Anatomy and pathology of the kidney by gray scale ultrasound 总被引:1,自引:0,他引:1