甲状腺乳头状微小癌124例的治疗和预后分析

Objective To investigate the treatment and prognosis of patients with papillary thyroid microcarcinoma. Methods The clinical and following-up data of 124 patients with papillary thyroid microcarcinoma treated at the Department of Head and Neck Surgery of Cancer Centre, SUN Yat-sen University from Jan 1990 to Dec 1999 were analyzed retrospectively for mortality and survival rate ( KaplanMeier). A multivariate analysis was performed in these patients by Cox proportional hazard model. Results The overall 10-year and 15-year survival rate of all 124 patients with papillary thyroid microcarcinoma were 94.9% and 92.5% respectively. The univariate analysis showed the prognostic factors significantly influencing the survival of patients included age (being worse for those of 35 years and older) at presentation, and the status of distant metastasis ( all P ＜ 0. 05 ) , while gender, incidentally found at surgery, the size of primary tumor, the status of neck lymph node metastasis, recurrence after a primary resection, and the extent of surgical resection did not significantly effect the prognosis. Multivariate analysis showed the age more than 35 years at presentation was an independent risk factor indicating worse prognosis (P = 0. 045 ). Conclusioas The prognosis of patients with papillary thyroid microcarcinoma is satisfactory, but that is poor for those patients 35 years old and up at presentation and with distant metastasis.     

甲状腺乳头状微小癌124例的治疗和预后分析

Objective To investigate the treatment and prognosis of patients with papillary thyroid microcarcinoma. Methods The clinical and following-up data of 124 patients with papillary thyroid microcarcinoma treated at the Department of Head and Neck Surgery of Cancer Centre, SUN Yat-sen University from Jan 1990 to Dec 1999 were analyzed retrospectively for mortality and survival rate ( KaplanMeier). A multivariate analysis was performed in these patients by Cox proportional hazard model. Results The overall 10-year and 15-year survival rate of all 124 patients with papillary thyroid microcarcinoma were 94.9% and 92.5% respectively. The univariate analysis showed the prognostic factors significantly influencing the survival of patients included age (being worse for those of 35 years and older) at presentation, and the status of distant metastasis ( all P ＜ 0. 05 ) , while gender, incidentally found at surgery, the size of primary tumor, the status of neck lymph node metastasis, recurrence after a primary resection, and the extent of surgical resection did not significantly effect the prognosis. Multivariate analysis showed the age more than 35 years at presentation was an independent risk factor indicating worse prognosis (P = 0. 045 ). Conclusioas The prognosis of patients with papillary thyroid microcarcinoma is satisfactory, but that is poor for those patients 35 years old and up at presentation and with distant metastasis.     

2539例甲状腺疾病构成分析

目的分析我院甲状腺疾病的构成特征,为防治工作提供依据。方法回顾2003年至2011年我院首次就诊2539例甲状腺疾病患者病案资料,总结甲状腺疾病患者临床资料特点,分析患者的性别、年龄特点及变化趋势。结果甲状腺疾病患病率呈逐年增长趋势,男女比例为1∶4.16,其中恶性病变占40.21%,中位年龄44岁,良性疾病占59.79%,中位年龄47岁。40岁~49岁达到峰值,随后恶性疾病患病率开始下降,而良性疾病进入平台期,70岁后开始下降。结论甲状腺患病呈上升趋势,以中年女性多发,40岁~49岁为高危年龄段,同时年轻化趋势明显,应加强甲状腺的普查及其相关知识的宣传以期早诊早治。     

政府在垃圾处理产业的作用

从立法、执法、产业体系导入、作业参与和监管等方面强调了政府的作用、政府是垃圾处理的责任主体，是垃圾处理产业的推动者、引导者、规范者和监督者，同时也是重要的参与者，起着不可取代的作用，     

SELDI-TOF-MS技术与头颈部肿瘤的诊断

表面增强激光解吸电离飞行时间质谱技术(surface-enhanced laser desorption/ionization time-of-flight mass spectrometry,SELDI-TOF-MS)是近年出现的蛋白质组学研究新技术,其综合了蛋白芯片和质谱技术的优点,可快速、高通量捕捉血清、组织及体液中的特异性蛋白质.本文就SELDI-TOF-MS技术相关的原理、特点及其在头颈肿瘤诊断中的应用进展做一综述.     

鼻修复及再造术11例

鼻修复及再造术１１例隋军＊后群＊王文慧＊张秀华全鼻或大面积鼻缺损的手术修复方法很多，主要有前额带蒂组织瓣，前臂带血管蒂组织瓣，游离组织瓣、颞浅血管蒂筋膜复合岛状瓣及鼻唇沟外有蒂对称双翼皮瓣等。各种方法都具有其优缺点，我科自１９８５年以来采用前三种方...     

儿童单侧感音神经性聋的病因学分析

通过对４１例（５０耳）单侧感音神经性聋患儿进行纯音听力、声导抗、血糖、血脂、甲状腺功能及ＣＴ检查，对儿童单侧感音神经性聋的病因进行了分析，结果表明：所有患儿血糖、血脂均正常，甲状腺功能也无明显变化；病毒感染、内耳血管畸形可能是致聋的主要原因；对这些患儿应进行定期追踪观察，以排除肿瘤的可能；对小儿原因不明的反应力及学习成绩下降应进行常规听力测定以求早期诊断，提高治疗有效率。     

医院领导者效能考评方法及相关因素

科学、技术与管理被誉为社会进步与发展的三大动力,管理起着决定性作用。而管理的效果如何,关键是看领导者的效能。医院领导者效能是各级医院负责人工作活动的出发点及归宿,亦指其实施领导活动中的行为能力、工作状态和最终实际效果,是衡量医院领导活动优劣的综合尺度。正确考评医院领导者的效能,对于提高其领导水平,加强医院技术队伍建设,密切党和人民群众关系,保证医院各项工作的顺利开展有着十分重要的意义。     

pSIREN-HIF-1α/shRNA表达载体的构建与鉴定

目的构建pSIREN-HIF-1α/shRNA重组质粒并测序鉴定,为下一步探索鼻咽癌基因治疗的RNA干扰（RNA interference,RNA）i途径奠定基础.方法根据基因库HIF-1αcDNA序列（NM₀01530/NM₁81054）以及Reynolds设计原则,设计并合成两端有酶切位点的60个碱基的寡核苷酸链,退火成互补双链后将退火产物与RNAi-Ready pSIREN-RetroQ-ZsGreen载体链接后,热转化至大肠杆菌JM109菌株中,提取质粒进行1%琼脂糖凝胶电泳鉴定,测序分析.结果 PCR扩增片段出现约470 bp大小的目的基因条带,与预期结果相符;凝胶电泳证实重组载体构建成功,插入片段测序结果与合成的寡核苷酸序列一致.结论成功构建重组质粒pSIREN-HIF-1α/shRNA,为下一步用脂质体包装并转染鼻咽癌细胞的研究奠定基础.