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The present study aims at ascertaining thenature of Xin Qi Xu (XQX,deficiency of Heart-Qi) and the effect of the drug Sheng Mai San 生脉散(SMS) on heart performance,using systolicand diastolic time intervals as criteria in CHDassociated with XQX patients.The results ascompared with normal subjects showed increa-ses in QA_2,PEP,ICT,IRP,SFP,RFP,a/H%,PEP/LVET and SFP/RFP and a reduction ofLVET,suggesting that the patients have a la-tent cardiac insufficiency possibly relating tothe nature of XQX.The changes in systolic anddiastolic time intervals after intravenous ShengMai San were prolongation of MST and LVET,shortening of PEP and PEP/LVET,and slowingof heart rate.These changes are statisticallysignificant (P<0.05-0.001).The blood pressurewas not significantly changed.These changesand their degree suggest a positive inotropic ac-tion on myocardium and a reduction of myo-cardial oxygen consumption by Sheng Mat San.Its effects compared with Cedilanid-D showedthat the action of both drugs on systolic anddiastolic time intervals was similar.We ten-tatively suggest,therefore,that the inotropicaction of SMS simulates that of digitalis glycosi-des.Further studies are needed to determinewhether SMS affects the heart in the same wayas digitalis glycosides,for current work indica-tes that SMS may have other effects on theheart. 相似文献
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