原发性闭角型青光眼对角膜内皮细胞的影响

青光眼是全球第二大致盲性眼病,除了损伤视神经、视野外还会影响虹膜、晶状体。临床观察和实验研究都表明青光眼可引起角膜内皮细胞数量减少,从而导致角膜透明性下降。我国以原发性闭角型青光眼患者居多,约占世界闭角型青光眼患者的一半,本文从原发性闭角型青光眼疾病本身、抗青光眼药物、手术及激光治疗等方面对角膜内皮细胞的影响进行综述。     

环戊硫酮治疗干眼的临床疗效评价

Objective To investigate anethol trithione therapic efficiency on dry eye. Methods It was a prospective random double-blind controlled study. Eighty cases diagnosed dry eye in Ocular Surface Out-patient Clinic of Xiamen University Affiliated Xiamen Eye Center from 2006 to 2008 were divided into two groups: anethol trithione group and control group, 40 cases in each group. Every group was then divided into two subgroups: weak dry eye subgroup, middle and severe dry eye subgroup. All groups had been added with 0.05% refresh drops. All patients had been detected and evaluated by subjective symptoms of dry eye, visual acuity,corneal fluorescent staining(F1), break-up time(BUT) and Schirmer Ⅰ test (SⅠT) at pre-therapy and 3,7,28 d of post-therapy. All groups had been compared and analyzed by F test and sample mean difference (SMD) or median difference (MD) comparison between pre-therapy and post-therapy. Results Except of tear and red eye, the other subjective symptoms of dry eye, F1, BUT and SⅠT of weak dry eye subgroup of both groups had been improved at 7 d after therapy. Only those of middle and severe dry eye subgroup of anethol trithione group had been improved at 7 d after therapy compared with those of pre-therapy: SMD=0.96 (visual tiredness), 1.26 (dry and unsmooth sensation), 0.82 (foreign body sensation), 1.28 (burning sensation), 1.05 (photophobia), 1.48 ( pain ) ; MD=0.30 (visual acuity), 4.00 (F1) ,5.00 (BUT), 5.00 (SⅠT) [F=15.30 (visual tiredness), 15.68 (dry and unsmooth sensation ), 13.56 (foreign body sensation), 20. 91 ( burning sensation ), 18.90 (photophobia), 27.22 ( pain ), 10.54 (visual acuity), 188.21 (F1) ,261.76 (BUT) ,269.05 (SⅠT) ;P<0. 05]. Those of middle and severe dry eye subgroup of control group hadn't significantly been improved at 28 d after therapy: SMD=0.10 (visual tiredness) ,0.16 (dry and unsmooth sensation) ,0.09 (foreign body sensation) ,0.38 ( burning sensation ), 0.24(photophobia) ,0.36 (pain) ,0.23 (red eye) ; MD=0.10 (visual acuity) ,0.50(F1) ,0.50(BUT), 0.50(SⅠT) [F=1.76 (visual tiredness), 1.61 (dry and unsmooth sensation), 1.02 (foreign body sensation),2.39 (burning sensation), 2.42 (photophobia), 2.73 ( pain ), 2.55 ( red eye ), 1.46 ( visual acuity) ,2.35 (F1) ,2.90 (BUT) ,2.76 (SⅠT) ; P>0.05]. SⅠT of anethol trithione group had been improved more significantly after therapy (F=13.77, P<0.05). Conclusion Anethol trithione could significantly improve middle and severe dry eye patients' symptoms and signs whose lacrimal gland function survival and it has clinical application value.     

张安富主任中医师辨治胆心综合征的经验

本文对张安富主任中医师辨证治疗胆心综合征的经验做一总结,张主任认为胆心综合征治疗方法及原则应依据胆、心两脏所喜所恶所欲及生理特点,病理转化机制,病性的寒热虚实,明确标本缓急,分清胆心综合征内科和外科的治疗范畴,辨证施治,才能取得满意疗效。本文详细归纳了张主任所分十个证型的理法方药,旨在从中医辩证论治角度指导本病的治疗。     

瓜蒌薤白半夏汤对不稳定型心绞痛患者MMP-9及TIMP-1的影响

目的:观察瓜蒌薤白半夏汤对不稳定型心绞痛(unstable angina,UA)痰浊闭阻证患者的临床疗效及对基质金属蛋白酶-9(matrix metalloproteinase,MMP-9)、基质金属蛋白酶抑制剂-1(tissue inhibitor of matrix metalloproteinases,TIMP-...     

上海市某学校一起乙型流行性感冒疫情调查

近几年,甲型流行性感冒(流感)暴发疫情时有发生,而乙型流感疫情报道甚少。2015年12月15日,上海市某小学报告一起流感样病例暴发疫情。为调查疫情规模,查明可疑危险因素,并提出针对性预防控制措施和控制疫情蔓延,预防类似事件的发生,我们开展了本次调查。     

CD8+T细胞耗竭发生和特征及其与肿瘤免疫治疗耐药的研究进展

免疫检查点抑制剂（immune checkpoint inhibitors,ICIs）是治疗多种肿瘤的重要手段,但耐药成为其最大难题。肿瘤免疫治疗耐药与肿瘤微环境（tumor microenvironment,TME）密切相关,TME中CD8⁺T细胞耗竭不仅持续性高表达抑制性受体（inhibitory receptors,IRs）,同时也是导致ICIs耐药的关键环节,靶向IRs为克服免疫治疗耐药提供了新思路。本文将重点对CD8⁺T细胞耗竭发生和特征及其与肿瘤免疫治疗耐药性相关的研究进行综述。     

超声、DR及MRI对膝骨性关节炎的诊断价值比较

目的 对比分析超声、数字X线摄影(DR)及磁共振成像(MRl)对膝骨性关节炎的诊断价值。方法 选取2017年6月至2019年6月我院收治的KOA患者70例,均行DR、超声及MRI检查,比较三种检查方法 对各KOA征象的检出率。结果 DR检查对于KOA骨质增生、骨质疏松等骨性病变的检出率分别为85.71%、54.29%,均明显高于超声(65.71%、0.00%)及MRI检查(68.57%、0.00%),有统计学差异(P<0.05)。而在非骨性改变的显示上,超声与MRI对髌上囊积液、滑膜增厚、关节软骨退变、软骨下骨破坏、半月板退变、腘窝囊肿、韧带损伤的检出率分别为81.43%、81.43%、88.57%、51.43%、35.71%、48.57%、11.43%与82.86%、84.29%、91.43%、 54.29%、44.29%、 48.57%、14.29%,均明显高于DR检查(P<0.05);但超声与MRI比较无统计学差异(P>0.05)。结论 DR、超声及MRI均对KOA有重要诊断价值;对于非骨性改变的,超声及MRI较DR片具有明显优势,而DR片能够更好地检出骨性改变...     

精神分裂症超高危人群前驱期症状的研究进展

精神分裂症是一种重性精神疾病,大多患者有前驱症状,了解发病的危险因素（遗传因素等）、早期症状的识别、诊断以及早期如何干预,对降低精神分裂症的发病及预后有重要的意义。本文从多方面进行归纳总结,阐述精神分裂症发病的可能因素,为寻找更加适合精神分裂症超高危人群的筛选方法以及恰当的早期干预提供依据。     

术中上、下肢静脉输液静脉炎发生率的比较

目的：探讨手术中上、下肢静脉输液对静脉炎发生率的影响。方法：选择下肢内踝大隐静脉和上肢腕部头静脉,使用静脉留置针。结果：下肢静脉炎发生率高于上肢,有显性差异（P＜0.01),各年龄组静脉炎的发生率,有明显差异（P＜0.05)。结论：上肢静脉瓣数量较少,静脉路径相对较短,手术时应选择上肢静脉输液,对年轻手术患更应重视静脉炎的预防。     

幸福的尺寸

很多的东西可以拿个计算器,好好计算一下,唯有感情,不是简单地一加一。6月9日,我结束了长达6年的婚姻生活,重新走入单身的行列。拿了必备的行李,上了飞机,目的地是欧洲。我们曾计划无数次旅游的地方,却一次没有实现。如果说一个人的寂寞是无奈的,那经历过两个人再回到一个人的时候,那种寂寞更是致命的。到了法国之后,我才知道香榭丽舍并不如我想象得