环境污染与不孕不育

目前,全球各地的不孕症发生率呈明显上升趋势。生殖医学专家指出,越来越恶劣的自然环境,各种污染可能是生育能力的杀手。工业化的巨大发展在给人类带来暂时利益的同时也潜伏下严重危害。人类每年向环境中排放大量有毒化学物质,包括内分泌干扰物、有机溶剂、杀虫剂、重金属等,这些环境污染物通过食物链进人人体和动物体内蓄积,不仅多方面危害人类自身的健康,还严重影响人类的繁衍。由环境污染所导致的不孕不育已经引起人们的广泛关注。1影响生育力的环境因素随着现代化的发展,人类每年要制造出1000多种有害的化学合成物质,其中有许多化学结构…     

EFFECT OF ELECTROACUPUNCTURE ON THE IMMUNOREACTIVITY OF FOCAL CUTANEOUS μ-OPIOID RECEPTOR IMMUNOREACTION-POSITIVE FIBERS IN ADJUVANT ARTHRITIC RATS

Objective: To study the effect of μ-opioid receptor (MOR) expression in the inflammatory skin tissue and the effect of electroacupuncture (EA) on the topical immunoreaction (IR) of MOR positive fibers in adjuvant arthritic (AA) rats. Methods: A total of 48 SD rats were randomized into control (n = 8), model (n = 10), focus-side-EA (n = 10), non-acupoint-EA (n = 10), and healthy-side-EA (n = 10) groups. AA model was established by subcutaneous injection of complete Freund's adjuvant (CFA, 50 μL) into the left hind paw. EA (4-16 Hz, 0.5-1.5 V) was applied to "Huantiao" (环跳 GB 30) and "Yanglingquan" (阳陵泉 GB 34) on the focus or healthy side and non-acupoints for 30 min. Non-acupoints used were the two sites 5 mm to GB 30 and GB 34 on the healthy side. The topical MOR IR-positive fibers in the dermal and subcutaneous tissues of the focus was stained with immunohistochemical method. The severity of pain was detected by foot (ankle-joint)-bending test. Results: Compared with model group, the "foot-bending test" score decreased significantly in focus-side-EA group on the 9th and 11th day (P<0.05) and in non-acupoint-EA group on the 8th, 9th and 11th d after injection of CFA (P < 0.05), indicating that EA of bilateral GB 30 and GB 34 and non-acupoints all can relieve pain. From the 13th day on, no significant differences were found in "foot-bending test" scores among the 3 EA groups and model group (P >0.05). In comparison with control group, the area values of MOR IR-positive nerve fibers in the focus tissue were significantly higher in 3 EA groups (P<0.05). The area values of MOR IR-positive nerve fibers in the focus in model group and 3 EA groups were significant higher than that in control group (P<0.05). Compared with model group, the area values of MOR IR-positive fibers in focus-side-EA group and healthy-side-EA group increased significantly (P<0.05); while those of MOR IR-positive fibers in non-acupoint-EA group and healthy-side-EA group were significantly lower than that in focus-side-EA group (P<0.05), and no significant differences were found among model group, healthy-side-EA group and non-acupoint-EA group in the area of MOR IR-positive fibers (P>0.05), indicating a stronger effect of EA of acupoints on the focus side. Conclusion: EA of GB 30 and GB 34 can relieve inflammatory pain and up-regulate the expression of MOR IR-positive fibers in the focal skin tissues in AA rats, exerting anti-inflammatory and analgesic effects.     

麦咪康帕联合臭氧液治疗妊娠期阴道炎的临床观察

目的:研究麦咪康帕联合臭氧液治疗妊娠期阴道炎的临床效果.方法:均给予局部用药治疗,先用浓度为6PPM臭氧水冲洗阴道,治疗150例,每天1次,每次3分钟,疗程7天,最后放入麦咪康帕栓剂,每粒含硝呋太尔500mg 制霉菌素20万U,每日1粒,7次为1个疗程.结果:对于念珠菌性阴道炎治愈率高达90%以上;而对于细菌性阴道病及滴虫性阴道炎治愈率均在80%以上.结论:麦咪康帕联合臭氧液治疗妊娠期阴道炎效果确切.     

北京地区健康妇女阴道需氧菌群分析

目的:了解正常妇女阴道需氧菌群的构成。方法:对北京地区872例健康体检妇女进行阴道需氧菌群培养,对菌群的构成进行分析。结果:①阴道感染患者的阴道菌群培养的阳性率高于正常妇女(P<0.05),而年龄对菌群培养的阳性率无明显影响;②北京地区正常妇女阴道主要需氧菌群为草绿色链球菌、类白喉棒状杆菌,念珠菌、粪肠球菌和表皮葡萄球菌;③在月经周期的不同时段,阴道需氧菌群的构成亦不相同。结论:了解阴道正常菌群的构成情况将有助于促进阴道感染的临床治疗及研究。     

霉酚酸酯治疗进展迅速的慢性重度乙型肝炎的前瞻性对照研究

目的用霉酚酸酯(MMF)治疗进展迅速的慢性重度乙型肝炎以阻断重型肝炎的发生.方法进展迅速的慢性重度乙型肝炎患者60例随机分为治疗组(34例)和对照组(26例).对照组接受还原型谷胱甘肽、前列腺素E1及新鲜血浆、白蛋白等支持治疗,治疗组在对照组治疗方案的基础上加用MMF治疗.结果MMF治疗组治疗好转率为88.2%(30/34),明显高于对照组的65.4%(17/26,×2=4.53,P＜0.05).治疗组平均住院(19.3±6.3)d,对照组为(27.3±5.8)d,二者相比有显著性差异(t=4.98,P＜0.05).治疗组有5.9%(2/34)发展为慢性重型肝炎,对照组重型肝炎发生率为26.9%(7/26),二者相比有显著性差异(x2=5.12,P＜0.05).未观察到MMF有明显诱发继发感染、消化道出血及外周血白细胞减少等毒副反应.结论 MMF能安全地用于治疗进展迅速的慢性重度乙型肝炎,能有效地阻止其向慢性重型肝炎发展.     

重视维生素C的副作用

维生素C又称抗坏血酸，临床上不仅可用于心血管系统、消化系统等疾病，在外科、眼科和口腔科等方面也有广泛应用，但近十余年来其毒副作用屡有报道，现综述如下：     

自体巩膜壳下羟基磷灰石义眼座植入术

我科于１９９８年对１０例有严重眼球萎缩的病人,行眼球内容物剜除并自体巩膜壳下羟基磷灰石义眼座眶内植入术。术后如期装配义眼片,随访６～１０个月。现报告如下。１一般资料本组１０例共１０眼。男７例７眼,女３例３眼。年龄１９～４８岁。其中因严重的眼球破裂伤伴...     

新生儿急救处置台在新生儿窒息复苏中的作用

为了提高新生儿窒息的复苏成功率，我院采用新生儿急救处置台（宁波产ＨＫＮ－９３Ａ）对３１例新生儿窒息进行复苏，效果满意。１资料与方法１．１临床资料：资料来源于我院产科１９９６～１９９８年分娩的新生儿，１分钟Ａｐｇａｒ评分４～７分者６１例，男３３例，女２...     

中西医结合治疗产后盆底肌筋膜疼痛的研究进展

盆腔疼痛综合征的发病率不断提高, 是常见的一种危害妇女身体健康的疾病, 因其涵盖范围较广, 外加病理复杂, 因此不同机构在其定义方面也存在差异。近几年, 慢性盆腔疼痛综合征的发展促使人们愈加重视盆底肌筋膜疼痛(MFPP), 其发病率在14%～23%之间, 临床没有特异性表现, 因此认知率相对较低。疾病主要的特征性标志是患者的盆底肌肉、远端肌肉中可以触及肌筋膜触发点(MTrPs), 盆底、盆腔多个或一个慢性、急性肌肉疼痛是此类患者的主要表现, 疼痛程度不均, 且呈间歇性、持续性, 确诊难度大。本文主要分析产后MFPP患者应用中西医结合治疗的研究进展。