Utility of FDG-PET scanning in lymphoma by WHO classification

We retrospectively evaluated (18)fluoro-2-deoxyglucose positron emission tomography (FDG-PET) scans in 172 patients with lymphoma and correlated results with pathologic diagnosis using the World Health Organization (WHO) classification system. In total, FDG-PET detected disease in at least one site in 161 patients (94%) and failed to detect disease in 11 patients (6%). The most frequent lymphoma diagnoses were diffuse large B-cell lymphoma (LBCL; n = 51), Hodgkin lymphoma (HL; n = 47), follicular lymphoma (FL; n = 42), marginal zone lymphoma (MZL; n = 12), mantle cell lymphoma (MCL; n = 7), and peripheral T-cell lymphoma (PTCL; n = 5). FDG-PET detected disease in 100% of patients with LBCL and MCL and in 98% of patients with HL and FL. In contrast, FDG-PET detected disease in only 67% of MZL and 40% of PTCL. Comparison with bone marrow biopsies showed that FDG-PET was not reliable for detection of bone marrow involvement in any lymphoma subtype.     

基本消灭班氏丝虫病后的远期监测

本文报道采用海群生对象治疗加流行村全民服药和对象治疗加食用海群生药盐基本消灭班氏丝虫病后的纵向和横向监测结果。两种不同措施基本消灭丝虫病后已监测9－11年，人群微丝蚴率均在逐年下降，前6年仍可检出残存微丝蚴血症者，以后连续5年未再发现微丝蚴阳性，蚊媒调查亦未发现幼丝虫自然感染，IFAT检测人群丝虫抗体阳性率为1．4－5．5％，降至非丝虫病流行区抗体水平，证明丝虫病的传播已被阻断。认为基本消灭班氏丝虫病后监测年限以10年左右为宜，并需连续3年以上未检出微丝蚴血症者和感染蚊，人群丝虫抗体阳性率降至当地非流行区水平，可以确认丝虫病已达到消除。     

内镜联合药物治疗放射性胃炎并发难治性出血一例

放射性胃炎并发难治性出血是肿瘤放疗后的并发症，但关于其治疗方法的报道和研究相对较少。本文描述了1例肝癌切除术后、放射治疗引起的放射性胃炎并发难治性出血采用氩离子凝固技术联合聚桂醇硬化治疗的过程及体会。     

Experimental infection of pregnant rabbits with hepatitis E virus demonstrating high mortality and vertical transmission

A high mortality rate of approximately 20% in pregnant women with hepatitis E has been reported in previous studies. However, other studies showed no difference between pregnant and nonpregnant women in the severity of hepatitis E. To determine the effects of HEV infection on pregnancy, we successfully established HEV infection in six pregnant rabbits (PR) and six nonpregnant rabbits (NPR) with a rabbit HEV isolate, taking three PR and one NPR without HEV infection as controls. Tests for HEV RNA by RT‐PCR, anti‐HEV antibodies by ELISA and HEV antigen via immunohistochemistry and histopathology were carried out. Two of six infected PR miscarried and three of the remaining four PR died which may be attributed to severe liver necrosis caused by HEV infection. Moreover, vertical transmission was found to be associated with the replication of HEV in placenta, indicated by the presence of HEV RNA and antigen in placenta from the infected PR. Our findings strongly suggest that HEV infection could lead to adverse outcomes in pregnancy and vertical transmission, suggesting the necessity for pregnant women at risk of HEV infection to be vaccinated.     

泌尿系感染对肾结石复发影响的临床探讨

目的探讨泌尿系感染对肾结石复发的影响。方法回顾性分析2012-06~2013-06该院收治的108例肾结石患者抗感染治疗及结石复发的临床资料。结果术后随访12~24个月,108例肾结石患者中,结石复发15例(13.9%)。其中出院前尿常规WBC阳性组23例,复发11例,复发率为47.8%,阴性组85例,复发4例,复发率为4.7%,两组比较差异有统计学意义(P0.05)。感染性结石组29例,复发12例,复发率为41.4%,非感染性结石组79例,复发3例,复发率为3.8%,两组比较差异有统计学意义(P0.05)。结论临床需加强抗感染治疗,控制尿路感染,预防感染性结石的发生。     

A sensitive duplex nanoparticle-assisted PCR assay for identifying porcine epidemic diarrhea virus and porcine transmissible gastroenteritis virus from clinical specimens

In this study, a novel duplex nanoparticle-assisted polymerase chain reaction (nanoPCR) assay was developed to detect porcine epidemic diarrhea virus (PEDV) and porcine transmissible gastroenteritis virus (TGEV). Two pairs of primers were designed based on the conserved region within the N gene of PEDV and TGEV. In a screening of 114 clinical samples from four provinces in China for PEDV and TGEV, 48.2 and 3.5 % of the samples, respectively, tested positive. Under optimized conditions, the duplex nanoPCR assay had a detection limit of 7.6 × 10¹ and 8.5 × 10¹ copies μL^?1 for PEDV and TGEV, respectively. The sensitivity of the duplex nanoPCR assay was ten times higher than that of a conventional PCR assay. Moreover, no fragments were amplified when the duplex nanoPCR assay was used to test samples containing other porcine viruses. Our results indicate that the duplex nanoPCR assay described here is useful for the rapid detection of PEDV and TGEV and can be applied in clinical diagnosis.     

管道铸型技术与血管造影3D可视化相结合

目的:以肝为例,探索将管道铸型与血管造影及3D可视化技术进行整合,充分揭示同一器官内部各管道系统之间的相互关系。方法:分别从肝静脉灌注自凝牙托灌注填充剂,从肝门静脉灌注乳胶、羧甲基纤维素-氧化铅填充剂。运用多层螺旋CT进行层距0.5mm薄层扫描,获取二维数据,应用Mimics软件对肝内的管道系统进行3D可视化。结果:重建后的肝门静脉充盈饱满,层次清晰,边缘光滑,层次分明。排除干扰后,自凝牙托材料灌注的肝静脉同样可以在运用CT扫描后,获取理想的管道三维重建模型。图像融合后能清晰显示肝门静脉和肝静脉在肝内的相互位置关系。结论:采用管道铸型技术与血管造影3D可视化相结合技术,不仅能在同一器官同时显示各管道系统的相互关系,更能在同一器官分别显示各管道系统。