重度抑郁症大学生经短周期有氧运动处方干预后抑郁症状和心肺功能的变化

目的:观察短周期有氧运动处方的干预对重庆抑郁症大学生抑郁症状和心肺功能的影响。方法:于2005-09/10选择陕西省西安市8所高校中的11例患抑郁症的大学生,男6例,女5例;年龄18～25岁。均符合美国社会精神疾病的诊断统计手册标准重度抑郁症的诊断标准;均对干预方案知情同意。采用自编运动处方,即修订跑台测试方法进行有氧运动干预,训练在每周一至周六进行,每日进行5组,每组3min,共干预3周;强度以周围毛细血管血乳酸浓度达(3.0±0.5)mmol/L为标准,组间间歇期为其1/2强度至恢复,乳酸浓度监测在每第6个训练计划日进行。心率作为监测指标,由于对于训练计划的适应,心率会逐步降低,所以通过提高跑台的转速增加运动强度。运动强度评价采用Bord自我用力感觉量表,强度保持在13,14级(比较困难)。检测最大摄氧量,以反映心肺功能耐力运动表现。在训练计划开始和结束时用汉密顿抑郁量表(5级评分,0～4分,分数越高表示抑郁症状越严重)评估患者抑郁症严重程度。结果:患抑郁症大学生11名均进入结果分析。训练后患抑郁症大学生汉密顿抑郁量表分为(13.12±5.54)分,较训练前明显下降[(19.55±3.30)分,P<0.01]。训练前后患抑郁症大学生最大摄氧量分别为(35.24±10.10),(33.91±10.23)mL/(kg·min),两者比较,差异不明显(P=1.000)。结论:重度抑郁症大学生经短周期有氧训练后,抑郁症状明显改善,心肺功能未见明显增强。     

Biologic effects of hyperthermia and radiation on gastric cancer cells (SGC-7901) in vitro. II. Ultrastructural changes of cells

Different characteristic damages of the SGC-7901 gastric adenocarcinoma cells were studied by electron microscopy 1, 36, 72, 96 and 120 hours after heating and radiation in vitro. The visible damages, such as the enlarged mitochondria, increase of lysosomes and perichromatin granules could be shown 1 hour after heating (43 degrees C for 30 min) but no visible damages of the cells were shown until 36 hours following radiation (500 rad). In order to study the ultrastructural changes of the gastric cancer cells in mitosis after heating and radiation, we have used the new method of ultrastructural research in selecting and observing the M cell in vitro and found loosened structure of chromosome and disappearance of microtubules 1 hour following hyperthermia. At the same time, no apparent abnormalities of the mitotic cells were observed after radiation. It is the chief cause of division delay in heat injured cells. However, the chromosomes and microtubules of the new mitotic cells could recover 36 hours after heating (43 degrees C for 30 min). After radiation, the giant cells and abnormal morphologic changes of cells gradually increase and the living cells decrease. Unexpectedly, the division of a few giant cells is observed 72 hours after heating and radiation.     

法莫替丁冲剂在健康人中的生物利用度及药动学研究

本实验采用反相高效液相色谱法，比较了１０名健康志愿者单剂量口服法莫替丁冲剂及等剂量片剂的生物利用度。结果表明：二种剂型的Ｔｍａｘ，Ｃｍａｘ，ＡＵＣ均无显著性差异（Ｐ〉０．０５）。冲剂相对于与片剂的相对生物利用度Ｆ＝１０１．９０。     

月骨,三角骨周围性腕骨轴向崩解症

本文报告３例罕见的新鲜性月骨、三角骨周围性腕骨轴向崩解症。该症是在腕的三个纵向功能解剖的基础上，遭受了以纵向为主兼有侧向偏斜的暴力而发生的。它的基本病变是月骨及三角骨与桡骨关系正常，而其余腕骨皆在其三个纵轴间发生崩解，致使患腕在结构上出现了严重紊乱。在这种复杂的病变中月骨和舟骨起着关键的作用，亦是腕骨轴向崩解的基础。本病在受伤机制、临床诊断以及治疗方法上，均与月骨周围性脱位或创伤性腕骨轴向脱位有着明显的区别，因而本病应视为一种独立的病种。本组病例有桡偏型２例，采用切开复位；另１例为尺偏型，采用闭合手法而顺利复位。本组病例经７～３６个月的随访，结果表明患腕功能恢复良好。     

An Analysis of Chromosome on Sterility Caused by Azoospermia or Oligospermia

ＡｎＡｎａｌｙｓｉｓｏｆＣｈｒｏｍｏｓｏｍｅｏｎＳｔｅｒｉｌｉｔｙＣａｕｓｅｄｂｙＡｚｏｏｓｐｅｒｍｉａｏｒＯｌｉｇｏｓｐｅｒｍｉａ￥ＷｕＭｅｉｈｅｎｇ；ＴａｎｇＷｉｎｇｎｕｏ．（ＡＣＴＡＡＣＡＤＥＭＩＡＥＭＥＤＩＣＩＮＡＥＮＡＮＪＩＮＧ，１９９５（...     

浅谈如何提高医疗质量

为提高医疗质量，论述以下三点：①强调“以病人为中心”，坚持服务方向、整合优化流程、收集反馈信息；②加强医务人员思想道道修养，在加大教育、监督、管理力度三个方面下功夫；③强化引导管理模式，采取开展质量分析、狠抓环节质控、进行法律法规引导等方法收到较好效果。     

吸入一氧化氮对心瓣膜置换术后肺动脉高压患者血流动力学的影响

目的：观察吸入一氧化氮（ＮＯ）对心瓣膜置换术后肺动脉高压患者血流动力学的影响。方法：选择９例心瓣膜置换术后伴肺动脉高压的病人，吸入ＮＯ０．００３％，观察三个时象点：吸入ＮＯ前；开始吸入ＮＯ后１５分钟；停止吸入ＮＯ后１５分钟。结果：吸入ＮＯ能显著降低肺动脉压和肺循环阻力指数（Ｐ＜０．０１），停止吸入ＮＯ１５分钟后，肺动脉压和肺循环阻力指数恢复到原有水平。在整个观察过程中，心率、平均动脉压、中心静脉压、肺动脉楔压、体循环阻力指数和心脏指数均无显著变化（Ｐ＞０．０５）。结论：吸入ＮＯ具有选择性肺血管扩张作用，是治疗心瓣膜置换术后肺动脉高压的较理想药物。     

Brain neurons and glial cells express Neu differentiation factor/heregulin: a survival factor for astrocytes.

Neu differentiation factor (NDF, also called heregulin) was isolated from mesenchymal cells on the basis of its ability to elevate phosphorylation of ErbB proteins. Earlier in situ hybridization analysis showed that NDF was transcribed predominantly in the central nervous system during embryonic development. To gain insights into the role of NDF in brain we analyzed its distribution by immunohistochemistry and in situ hybridization. Late-gestation (day 17) rat embryos displayed high NDF immunoreactivity in both motor (e.g., putamen) and limbic (e.g., septum) regions. Lower levels of the factor were exhibited by adult brain, except for the cerebellum, where NDF expression was increased postnatally. Both neurons and glial cells were identified by immunohistochemistry as NDF-producing cells (e.g., pyramidal neurons in the cerebral cortex and glial cells in the corpus callosum). By establishment of primary cultures of rat brain cells we confirmed that NDF was expressed in neurons as well as in astrocytes. In addition, by using such primary cultures we observed that NDF treatment exerted only a limited mitogenic effect, which was accompanied by significant acceleration of astrocyte maturation. Furthermore, long-term incubation with the factor specifically protected astrocytes from apoptosis, implying that NDF functions in brain as a survival and maturation factor for astrocytes.     

脑肿瘤伴发精神障碍─—附36例分析

９８例颅内肿瘤经手术和病理检查证实，其中３６例脑瘤伴精神障碍，最常见的精神症状是情感淡漠，情感不稳，遗忘，意识模糊，嗜睡、痴呆。为最常见的部位为额顶部和颞叶部。