The Relationship Between Sexual Quality of Life, Happiness, and Satisfaction with Life in Married Turkish Women

The quality of sexual life is based on a physical, relational, and emotional assessment of an individual. This study aimed to analyze the relationship between sexual quality of life, happiness, and satisfaction with life. The research comprised of 204 women, aged between 18 and 63. The average age of participants was 31.98. In this study, the sexual quality of life questionnaire-female, Oxford happiness questionnaire-short form, and satisfaction with life scale were used as data collection tools. The findings indicated that the sexual quality of life in women has a positive relationship with happiness and satisfaction with life. Therefore, sexual quality of life is a significant predictor of happiness and satisfaction with life. It also explains 19 % of the variance concerning happiness and 25 % of the variance regarding satisfaction with life. As a result, the findings obtained from the present study show that the sexual quality of life in women is important in relation to happiness and satisfaction with life.     

Knowledge and Opinions of Turkish University Students About Contraceptive Methods and Emergency Contraception

This study was carried out to determine the knowledge and opinions of university students about contraceptive methods and emergency contraception (EC). The study comprised 1,689 students who volunteered to participate in the study and were selected from among students studying in two different universities in the 2007–2008 semester. Data were collected on a form that was developed by researchers. The chi-square test was used for the statistical analysis of the data. Oral contraceptive pills (93%), condoms (91.3%), IUDs (Intra Uterine Device) (76.6%) and the withdrawal method (56.8%) were in the lead amongst the contraceptive methods on which students had information. Twenty-nine percent of the students had heard of the concept of EC and 79.8% of those defined the concept accurately. Out of the total student sample, 38.7% stated that they had no information about the methods used for the purpose of EC. 89.6% of the students were of the opinion that every individual should have information about contraceptive methods. Turkish university students were found to be aware of many contraceptive methods; in addition, the opinions of the young university students relating to family planning were positive.     

The fruit extract of three strawberry cultivars prevents lipid peroxidation and protects the unsaturated fatty acids in the Fenton reagent environment

In this study, we detected the flavonoid ingredients of three different varieties of strawberry (Fragaria ananassa Duch cultivar Camarosa, Selva and Dorit) grown in Elazig, and we researched on their effects on the radicals DPPH√ and OH√. It was detected that in the manipulation of 50-100 μl extract, it was efficient to turn the DPPH√ radical over 85% to DPPH√ OH√ form. In in vitro environment in which hydrogen peroxide and Fenton reagent were used, it was also detected that the capacity of interception of lipid peroxidation is high. When the level of Malondialdehyde (MDA)-2-thiobarbituric acid was compared with that of the Fenton R group, the level was shown to be decreased in the groups in which a quite distinct level of the extract of strawberry fruit was given (p < 0.001). Depending on the decrease in LPO formation, the amounts of oleic acid and linoleic acid that were added to the reaction environment were preserved in in vitro environment in which the extract of strawberry fruit was added (p < 0.01, p < 0.05 and p < 0.01).Consequently, it has been confirmed that the strawberry fruit that has a scavenging effect against the radicals prevents that lipid peroxidation in in vitro environment.     

Syntheses,Cholinesterases Inhibition,and Molecular Docking Studies of Pyrido[2,3‐b]pyrazine Derivatives

Cholinesterases, acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), have a role in cholinergic deficit which evidently leads to Alzheimer's disease (AD). Inhibition of cholinesterases with small molecules is an attractive strategy in AD therapy. This study demonstrates synthesis of pyrido[2,3‐b]pyrazines ( 6a ‐ 6q ) series, their inhibitory activities against both cholinesterases, AChE and BChE, and molecular docking studies. The bioactivities data of pyrido[2,3‐b]pyrazines showed 3‐(3′‐nitrophenyl)pyrido[2,3‐b]pyrazine 6n a potent dual inhibitor among the series against both AChE and BChE with IC₅₀ values of 0.466 ± 0.121 and 1.89 ± 0.05 μm , respectively. The analogues 3‐(3′‐methylphenyl)pyrido[2,3‐b]pyrazine 6c and 3‐(3′‐fluorophenyl)pyrido[2,3‐b]pyrazine 6f were found to be selective inhibition for BChE with IC₅₀ values of 0.583 ± 0.052 μm and AChE with IC₅₀ value of 0.899 ± 0.10 μm , respectively. Molecular docking studies of the active compounds suggested the putative binding modes with cholinesterases. The potent compounds among the series could potentially serves as good leads for the development of new cholinesterase inhibitors.     

Assessment of paraoxonase activity and lipid peroxidation levels in diabetic and senile subjects suffering from cataract

Objectives:The purpose of this study was to evaluate antioxidant effect of paraoxonase 1 activity and malondialdehyde (MDA) levels as a marker of oxidative stress in patients suffering from cataract due to diabetes and aging.Design and methods:One hundred cataract patients (senile and diabetic) and age- and sex-matched controls were studied. Paraoxonase 1 and arylesterase activities in plasma samples were measured using paraoxon and phenylacetate as substrates, respectively. The magnitude of lipid peroxidation was established by measuring plasma MDA and oxidized low-density lipoprotein (ox LDL) levels. One-way ANOVA was employed for analysis of results.Results:We observed significantly lower plasma paraoxonase and arylesterase activities in senile and diabetic cataractous patients as compared to respective controls (p < 0.001). Plasma MDA and ox LDL levels were found to be higher in patients suffering from cataract (p < 0.001).Conclusions:The results of present study suggest that the observed decrease in PON1 activity may be due to increase in oxidative stress. It can be concluded that lower paraoxonase activity could contribute to the higher risk of cataract formation.     

The quality of life and self-efficacy of Turkish breast cancer patients undergoing chemotherapy

Self-efficacy has a positive effect on health behaviors, symptom control, compliance with cancer treatment, and quality of life. This study aims to describe the quality of life and self-efficacy of Turkish breast cancer patients undergoing chemotherapy. The sample consisted of 141 patients. Data was gathered using a Patient Information Form, the Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B), a scale about Strategies Used by Patients to Promote Health and the Rotterdam Symptom Checklist. All quality of life dimensions were negatively affected at a significant level. Following commencement of chemotherapy, there was an increase in the negative effect on physical well-being, emotional well-being and additional concerns subscales and total FACT-B and their self-efficacy was negatively affected to a moderate degree. However, a significant degree of change did not occur in the self-efficacy. During treatment the physical symptoms and psychological distress increased and the activity level was negatively affected. The quality of life and self-efficacy were influenced by personal and medical characteristics, showing consistency with similar studies. Because there are negative effects of cancer and chemotherapy on patients' quality of life and self-efficacy, nurses need to focus on designing psychosocial interventions to improve their self-efficacy and quality of life.     

The XXXIV Spanish Congress of Pediatric Nephrology 4-7 June 2008, Sevilla, Spain

Abstracts

The XXXIV Spanish Congress of Pediatric Nephrology 4-7 June 2008, Sevilla, Spain