全文获取类型
收费全文 | 2809篇 |
免费 | 182篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 79篇 |
妇产科学 | 43篇 |
基础医学 | 379篇 |
口腔科学 | 103篇 |
临床医学 | 235篇 |
内科学 | 683篇 |
皮肤病学 | 109篇 |
神经病学 | 202篇 |
特种医学 | 131篇 |
外国民族医学 | 1篇 |
外科学 | 251篇 |
综合类 | 13篇 |
预防医学 | 123篇 |
眼科学 | 100篇 |
药学 | 222篇 |
中国医学 | 16篇 |
肿瘤学 | 284篇 |
出版年
2024年 | 6篇 |
2023年 | 46篇 |
2022年 | 82篇 |
2021年 | 147篇 |
2020年 | 76篇 |
2019年 | 109篇 |
2018年 | 137篇 |
2017年 | 109篇 |
2016年 | 102篇 |
2015年 | 99篇 |
2014年 | 121篇 |
2013年 | 142篇 |
2012年 | 233篇 |
2011年 | 266篇 |
2010年 | 128篇 |
2009年 | 98篇 |
2008年 | 188篇 |
2007年 | 157篇 |
2006年 | 161篇 |
2005年 | 139篇 |
2004年 | 129篇 |
2003年 | 116篇 |
2002年 | 99篇 |
2001年 | 15篇 |
2000年 | 8篇 |
1999年 | 14篇 |
1998年 | 24篇 |
1997年 | 10篇 |
1996年 | 13篇 |
1995年 | 11篇 |
1994年 | 3篇 |
1993年 | 5篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1987年 | 4篇 |
1985年 | 4篇 |
排序方式: 共有3007条查询结果,搜索用时 15 毫秒
61.
Kanaji N Bandoh S Takano K Kadota K Haba R Matsunaga T Kohno K Kushida Y Yamamoto Y Ishida T 《The American journal of the medical sciences》2008,335(4):310-314
Squalene is a type of oil obtained from shark liver. We describe a 76-year-old man diagnosed with chronic exogenous lipoid pneumonia due to squalene. A chest CT scan revealed pulmonary consolidation with ground-glass opacities in the right upper lobe. Positron emission tomography (PET) revealed significant uptake of 2-deoxy-2-F-fluoro-d-glucose (FDG) and 3'-deoxy-3'-F-fluorothymidine (FLT). Bronchoalveolar lavage (BAL) fluid contained many lipid-laden macrophages, and a transbronchial lung biopsy specimen showed clusters of foamy macrophages in alveolar spaces and granulomatous lesions. In addition, the presence of squalene in the BAL fluid was confirmed by gas chromatography-mass spectrometry, leading to a diagnosis of squalene-induced lipoid pneumonia. To the best of our knowledge, this is the first report of squalene-induced lipoid pneumonia in which squalene itself was successfully detected. This case also suggests the possibility that lipoid pneumonia shows significant uptake in FDG-PET and FLT-PET. 相似文献
62.
Sugimoto Y Nishii K Sakakura M Araki H Usui E Lorenzo V F Hoshino N Miyashita H Ohishi K Katayama N Shiku H 《The hematology journal : the official journal of the European Haematology Association / EHA》2004,5(1):84-89
We report a 31-year-old female with t(8;21)(q22;q22) acute myeloid leukemia (AML), M2 in the FAB classification. Complete remission was achieved with daunorubicin and cytarabine induction therapy followed by three courses of high-dose cytarabine consolidation. Only 3 months later, the patient relapsed with granulocytic sarcomas (GSs) in her rhinopharynx, external acoustic meatus, and bone marrow. She received focal radiation for the GSs and successfully underwent reinduction chemotherapy. Subsequently, she received a matched related donor peripheral blood stem cell transplantation followed by high-dose chemotherapy and is now in a second remission. We summarized 79 reported cases of t(8;21) AML with GS and reviewed the literature to identify differences in the characteristics of t(8;21) AML with GS between adults and children. To our knowledge, this is the first report of pharyngeal GS in t(8;21) AML, and focal irradiation plus more intensive postinduction therapy during first remission, such as allogeneic-SCT, may be effective in adult t(8;21) AML patients with GS. 相似文献
63.
Yuki Igarashi Sho Tashiro Yuki Enoki Kazuaki Taguchi Kazuaki Matsumoto Hiroki Ohge Hiromichi Suzuki Atsushi Nakamura Nobuaki Mori Yoshitomo Morinaga Yuka Yamagishi Sadako Yoshizawa Katsunori Yanagihara Hiroshige Mikamo Hiroyuki Kunishima 《Journal of infection and chemotherapy》2018,24(11):907-914
At present, vancomycin (VCM) and metronidazole (MNZ) are used for the first-line standard treatment of Clostridioides difficile infection (CDI). However, their differential use has not been sufficiently investigated. In this study, a meta-analysis on differences in the efficacy for CDI between VCM and MNZ was performed. Reports of randomized controlled studies using VCM or MNZ to treat CDI were surveyed. Meta-analysis was performed using the Mantel-Haenszel method and random-effects model, and the risk ratio and 95% confidence interval were calculated. Excluding overlapping reports, 1043 reports were extracted and 5 randomized controlled studies were extracted. There was no difference in therapeutic effects for CDI between VCM and MNZ (RR = 1.08, 95% CI (0.99–1.17), p = 0.09, I2 = 37%). On subgroup analysis by the severity, there was no difference in the clinical effects for CDI between VCM and MNZ in non-severe cases (risk ratio: 1.09, 95% confidence interval: 1.00–1.19, p = 0.06), but the clinical effects of VCM were significantly higher than those of MNZ in severe cases (risk ratio: 1.19, 95% confidence interval: 1.02–1.39, p = 0.03). No significant difference was noted in the recurrence rate, incidence of adverse event, time to exhibit therapeutic effects, or judgment of the bacteriological effects. As the therapeutic effects of VCM were superior in severe CDI cases, VCM should be considered first in severe cases. 相似文献
64.
Yukiko Kato Mao Hagihara Ai Kurumiya Tomoko Takahashi Miki Sakata Yuichi Shibata Hideo Kato Arufumi Shiota Hiroki Watanabe Nobuhiro Asai Yusuke Koizumi Yuka Yamagishi Hiroshige Mikamo 《Journal of infection and chemotherapy》2018,24(1):31-35
Background
Central line-associated bloodstream infections (CLABSIs) are among the most serious complications especially in blood cancer patients. In January 2013, Centers for Disease and Prevention (CDC) introduced a new surveillance definition of mucosal barrier injury-associated laboratory-confirmed bloodstream infection (MBI-LCBI). This study was to determine the impact of MBI-LCBI on CLABSIs and compare the clinical characteristics of MBI versus non-MBI-LCBI cases.Patients and methods
We retrospectively reviewed the records of 250 consecutive patients. They were admitted in department of hematology at Aichi Medical University Hospital. We applied the revised 2013 CLABSI surveillance protocol to all CLABSI cases identified during the 47-months period from May 2012 through June 2016.Results
A total of 44 CLABSIs were identified. The median patient age was 65 years (range, 12 to 89). Among 44 patients, 31 patients were diagnosed as leukemia (70.5%) and 12 patients as lymphoma (27.3%). Six patients underwent bone transplantation for leukemia or myelodysplastic syndrome (13.6%). A total of 20 patients (45.5%) were classified as MBI-LCBI and 24 (54.5%) were classified as non-MBI-LCBI. The primary disease type (P = 0.018), neutropenic within 3 days before CLABSI (MBI-LCBI vs. non-MBI-LCBI: 95.0% vs. 26.3%, P = <0.0001), line(s) removed owing to CLABSI (15.0% vs. 54.2%, P = 0.011) and Gram-negative organisms cultured (70.0% vs. 37.5%, P = 0.004) showed significantly difference between the groups.Conclusion
Our data showed that MBI-LCBI cases account for 45.5% of the CLABSI cases identified in blood cancer patients, and constituted a significant burden to this high-risk patient population. 相似文献65.
Yuka Yamada Ayako Wada Tomoyoshi Otsuka Kaori Muraoka Meigen Liu 《Disability and rehabilitation》2018,40(12):1421-1425
Purpose: Swallowing dysfunction has been reported in Duchenne muscular dystrophy (DMD), but has not been studied in Becker muscular dystrophy (BMD). The aims of this study were to report the characteristics of swallowing dysfunction in BMD compared with DMD.Materials and methods: The study participants were 18 patients with BMD and 18 patients with DMD. All the patients were examined using videofluorography during swallowing of 5?mL of fluid. The penetration–aspiration scale (P–A scale) and the videofluorographic dysphagia scale (VDS) were used to evaluate dysphagia.Results: Swinyard functional ability stage was not significantly different between the BMD and DMD groups. Rate of aspiration, P–A scale score, and total VDS score did not differ across groups, but the VDS item score for laryngeal elevation was lower in the BMD group than in the DMD group (median scores 4.5 and 9, respectively; p?0.001). In the BMD group, total VDS score significantly correlated with Swinyard stage (r?=?0.78, p?0.001), but not with age or lung function.Conclusion: Patients with BMD have swallowing problems similar to those observed in patients with DMD when matched according to physical functional status. These patients should be evaluated and followed-up for the duration of their disease.
- Implications for rehabiliation
Dysphagia is one of the most critical problems in patients with progressive neuromuscular disease but dysphagia in patients with Becker muscular dystrophy (BMD) was not well known.
Eighteen patients with BMD and 18 patients with Duchenne muscular dystrophy were examined with videofluorography.
Patients with BMD have swallowing problems similar to those observed in patients with DMD.
66.
Peter?S.?ReinachEmail author Stefan?Mergler Yuka?Okada Shizuya?Saika 《BMC ophthalmology》2015,15(1):153
Transient receptor potential (TRP) channels sense and transduce environmental stimuli into Ca2+ transients that in turn induce responses essential for cell function and adaptation. These non-selective channels with variable Ca2+ selectivity are grouped into seven different subfamilies containing 28 subtypes based on differences in amino acid sequence homology. Many of these subtypes are expressed in the eye on both neuronal and non-neuronal cells where they affect a host of stress-induced regulatory responses essential for normal vision maintenance. This article reviews our current knowledge about the expression, function and regulation of TRPs in different eye tissues. We also describe how under certain conditions TRP activation can induce responses that are maladaptive to ocular function. Furthermore, the possibility of an association between TRP mutations and disease is considered. These findings contribute to evidence suggesting that drug targeting TRP channels may be of therapeutic benefit in a clinical setting. We point out issues that must be more extensively addressed before it will be possible to decide with certainty that this is a realistic endeavor. Another possible upshot of future studies is that disease process progression can be better evaluated by profiling changes in tissue specific functional TRP subtype activity as well as their gene and protein expression. 相似文献
67.
Yuki Nakamura Tomohiro Uemura Yuka Kawata Bungo Hirose Rika Yamauchi Shun Shimohama 《Internal medicine (Tokyo, Japan)》2021,60(5):789
An 81-year-old man with a history of gingival bleeding presented with a fever, headache, and drowsiness. His mouth and full dentures were unsanitary. Laboratory tests revealed Streptococcus oralis meningitis caused by odontogenic bacteremia. We reviewed eight reported cases, including the present case, because S. oralis meningitis is rare. Our review indicated that S. oralis meningitis needs to be considered when encountering cases of a fever, disturbance of consciousness, and headache with episodes of possible odontogenic bacteremia. 相似文献
68.
Takahiro Kametani Yuichiro Otani Toshikazu Ohigashi Tadahiko Kubo Tomohiko Sakuda Daisuke Furuta Yayoiko Ito Yuya Shigenobu Masaki Kakimoto Akihiro Kawahara Yuka Kikuchi Tomoki Kobayashi Daisuke Miyamori Nobusuke Kishikawa Keishi Kanno Masanori Ito 《Internal medicine (Tokyo, Japan)》2021,60(8):1311
We herein report a case of aortitis induced by granulocyte colony-stimulating factor (G-CSF) that coincided with lung injury, splenomegaly, and cutaneous manifestations during treatment for recurrent extraosseous mucinous chondrosarcoma. Computed tomography revealed large-vessel vasculitis, splenomegaly, and pulmonary interstitial changes. Treatment with prednisolone was successful. Because sarcoma is a rare disease, this case is valuable for showing clinicians that G-CSF preparations could cause aortitis regardless of the patient''s underlying diseases or therapeutic pharmacological backgrounds. 相似文献
69.
Maki Komiyama Yuka Ozaki Yusuke Miyazaki Akihiro Yasoda Hiromichi Wada Hajime Yamakage Noriko Satoh-Asahara Tatsuya Morimoto Akira Shimatsu Yuko Takahashi Koji Hasegawa 《Internal medicine (Tokyo, Japan)》2021,60(8):1175
Objective The psychological status is a key factor in smoking continuance. However, details on short-term changes in mild depressive states after smoking cessation (SC) are still unknown. The purpose of the present study was to investigate these short-term changes. Methods A total of 989 patients who visited our SC Clinic were assessed using the Zung Self-Rating-Depression-Scale (SDS), an official instrument to measure depressive tendencies. The participants were classified into normal and neurotic groups based on their SDS scores during their initial visit; they were assessed again 2, 4, 8, and 12 weeks thereafter. Results The majority of patients in the neurotic group were women. These patients were also younger, with a higher nicotine dependence, and presented with a lower successful SC rate than the patients in the normal group. A decrease in SDS scores after starting the SC treatment was observed only in the neurotic group, especially during the first two weeks. In patients who continued to smoke, no improvement in depressive tendencies was noted in this period. Conclusion Depressive tendencies of patients with neurosis improve in the initial stages of the SC treatment (i.e., within two weeks after starting the treatment). This finding fills the mentioned knowledge gap regarding the effects of SC on mild depressive states in the short term. 相似文献
70.
Jiro FUJITA Yuka OBAYASHI Ichiro YAMADORI Yuji OHTSUKI Hiroshi MIYAWAKI Satoko HOJO Yoko FURUKAWA Jiro TAKAHARA 《Respirology (Carlton, Vic.)》1998,3(3):211-214
Abstract A 53-year-old Japanese female, who had been suffering from idiopathic pulmonary fibrosis (IPF) for 3 years, was admitted with dyspnoea. The important laboratory finding on admission was a serum CA19-9 level of 649 U/mL. Despite steroid treatment for IPF, her respiratory condition gradually deteriorated with the increase of serum CA19-9 level up to 3020 U/mL and she died of respiratory failure. Immunohistochemistry showed the positive stain of CA19-9 in bronchoepithelial cells. We also reviewed the Index Medics and picked up the cases who had elevation of CA19-9 more than 1000 U/mL, and six patients were listed. Five of these six patients died within 6 months, therefore the marked elevation of CA19-9 seemed to be a bad prognostic factor in patients with pulmonary fibrosis. 相似文献