全文获取类型
收费全文 | 7982篇 |
免费 | 830篇 |
国内免费 | 484篇 |
专业分类
耳鼻咽喉 | 31篇 |
儿科学 | 40篇 |
妇产科学 | 73篇 |
基础医学 | 1102篇 |
口腔科学 | 80篇 |
临床医学 | 1106篇 |
内科学 | 1512篇 |
皮肤病学 | 64篇 |
神经病学 | 436篇 |
特种医学 | 276篇 |
外国民族医学 | 15篇 |
外科学 | 867篇 |
综合类 | 925篇 |
现状与发展 | 4篇 |
预防医学 | 468篇 |
眼科学 | 69篇 |
药学 | 820篇 |
35篇 | |
中国医学 | 586篇 |
肿瘤学 | 787篇 |
出版年
2024年 | 27篇 |
2023年 | 174篇 |
2022年 | 476篇 |
2021年 | 643篇 |
2020年 | 485篇 |
2019年 | 424篇 |
2018年 | 418篇 |
2017年 | 362篇 |
2016年 | 391篇 |
2015年 | 568篇 |
2014年 | 659篇 |
2013年 | 625篇 |
2012年 | 760篇 |
2011年 | 787篇 |
2010年 | 506篇 |
2009年 | 410篇 |
2008年 | 390篇 |
2007年 | 350篇 |
2006年 | 309篇 |
2005年 | 328篇 |
2004年 | 64篇 |
2003年 | 60篇 |
2002年 | 28篇 |
2001年 | 12篇 |
2000年 | 6篇 |
1999年 | 7篇 |
1998年 | 4篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 4篇 |
1994年 | 4篇 |
1993年 | 2篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1964年 | 1篇 |
排序方式: 共有9296条查询结果,搜索用时 15 毫秒
31.
Lin-Bo Gao Bin Zhou Lin Zhang Ye-Sheng Wei Yan-Yun Wang Wei-Bo Liang Mei-Li Lv Xin-Min Pan Yu-Cheng Chen Li Rao 《BMC medical genetics》2008,9(1):74
Background
Previous studies suggested that genetic polymorphisms in the epidermal growth factor receptor (EGFR) gene had been implicated in the susceptibility to some tumors and inflammatory diseases. EGFR has been recently implicated in vascular pathophysiological processes associated with excessive remodeling and atherosclerosis. Acute coronary syndrome (ACS) is a clinical manifestation of preceding atherosclerosis. Our purpose was to investigate the association of the EGFR polymorphism with the risk of ACS. In this context, we analyzed the HER-1 R497K and EGFR intron 1 (CA)n repeat polymorphisms in 191 patients with ACS and 210 age- and sex-matched controls in a Chinese population, using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) strategy and direct sequencing. 相似文献32.
Dr Y. X. Yang B. S. Xie Z. X. Zhou J. N. Liu Y. Y. Xue G. L. Lv 《Medical & biological engineering & computing》1998,36(3):355-358
An experimental animal hypoxia model has been developed. It consists of two sensors (an in vitro and in vivo model), an experimental
device and a computer signal processing system. This method can easily be applied to determine and analyse blood oxygen saturation
at various hypoxia levels. It can also be used to evaluate the accuracy of pulse oximetry over a wide range of oxyhemoglobin
desaturation levels. The DC and AC components of recorded red and infra-red signals, the dual-wavelength ratio R12 and the reading of a pulse oximeter (SpO2) can be automatically calculated and displayed on a computer screen. Preliminary results of the animal hypoxia test indicate
that the measurements made by the instrument correlate well with the oxygen saturation readings of the automatic blood gas
analyser AVL945. The computer analysis system is suitable for repeated estimations in the animal model. 相似文献
33.
医疗机构实施ISO9001,其目的是为了提高医疗服务质量,满足病人一切明确和隐含的需求。那么,内审是否发挥作用,直接关系管理体系的有效性。文章对此进行了初步的探讨,即:①明确内审的目的是检查体系满足标准要求的程度;②建立正规的内审机构,要选拔责任心强、综合素质高的人担任内审员;③编制合理且有特色的内审计划,是内审有效性的关键;④适当增加专题审核;⑤医院最高管理者应重视内审结果。 相似文献
34.
目的探讨磷酸钙人工骨(CPC)在颈椎前路椎间融合手术中的应用效果。方法2001年4月至2003年10月颈前路手术中应用磷酸钙人工骨栓椎间融合结合钛钢板固定治疗颈椎病17例,颈椎间盘突出症5例,颈椎外伤脱位2例,共24例35个节段。采用JOA评分评价神经功能,X线片判定融合效果。结果随访18±6.5个月,术后无感染,无过敏或毒性反应。JOA评分由术前9.28±2.15分增加到14.65±2.18分(P<0.001)。术后X线片未见CPC骨栓塌陷或移位,钛板和螺钉无松动及折断。术后16.5±6.8个月均获得椎间融合。结论颈椎前路椎间融合手术应用磷酸钙人工骨替代自体骨,经济、安全、简便、效果可靠。 相似文献
35.
G.-Y. Wang B. Sun Q.-F. Kong Y. Zhang R. Li J.-H. Wang D.-D. Wang G. X. Lv & H.-L. Li 《Scandinavian journal of immunology》2008,68(6):589-597
Interleukin (IL)-17 is a proinflammatory cytokine primarily secreted by Th17 cells, which are a CD4+ T-cell subset. Th17 cells and IL-17 are important in the pathogenesis of multiple sclerosis and in its established animal model, experimental autoimmune encephalomyelitis (EAE). However, it is unclear whether IL-17 contributes to EAE immune tolerance. We used the myelin basic protein (MBP) peptide MBP 68–86 to induce nasal tolerance to EAE, and simultaneously interfered with the tolerance by treatment with different doses of IL-17. We found that IL-17 dramatically interfered with MBP 68–86-induced immune tolerance. IL-17 administration increased IL-6 release, skewing T cell differentiation towards Th17 cells and decreasing the number of Treg cells. This led to an imbalance between Treg cells and Th17 cells and spurred the development of EAE. 相似文献
36.
37.
Ketamine inhibits LPS-induced calcium elevation and NF-kappa B activation in monocytes 总被引:10,自引:0,他引:10
Objective:To investigate whether ketamine could inhibit lipopolysaccharide (LPS)-induced intracellular calcium elevation and NF-kappa B activation in monocytes.
Materials and methods:Isolated rat monocytes were challenged with 10 g/ml LPS with or without the presence of various concentrations of ketamine (10, 100, 1000 M). Intracellular calcium was monitored by laser confocal microscopy. NF-kappa B activity of the nuclear extracts of monocytes was analyzed by electrophoretic mobility shift assay (EMSA).
Results:LPS provoked a significant calcium elevation and enhanced NF-kappa B activity in monocytes. Ketamine above concentration of 100 M inhibited endotoxin-induced intracellular calcium elevation and NF-kappa B activity. Ketamine itself had no effect on either of them.
Conclusions:These findings suggest that ketamine could suppress NF-kappa B in monocytes exposed to endotoxin, and this anti-inflammatory effect might act through attenuating intracellular calcium elevation.Received 31 October 2003; returned for revision 18 December 2003; accepted by I. Ahnfelt-Rønne 26 Januaryy 2004 相似文献
38.
Characterization of a Novel Anti-DR5 Monoclonal Antibody WD1 with the Potential to Induce Tumor Cell Apoptosis 总被引:2,自引:0,他引:2
39.
40.
Tong Chen Jianglong Chen Qingfeng Sheng Linlin Zhu Xiaoling Bai Weijue Xu Jiangbin Liu Xiaoyan Li Zhibao Lv 《Journal of pediatric surgery》2021,56(4):800-804
BackgroundPyriform sinus fistula (PSF) is a rare congenital anomaly, and the preferred definitive treatment is yet to be verified. In this study, we investigated the treatment outcomes of PSF specifically comparing endoscopic-assisted surgery and endoscopic radiofrequency ablation (RA).MethodsThe medical records of patients treated for PSF at the Shanghai Children's Hospital between October 2016 and September 2019 were retrospectively evaluated.ResultsThere were 93 girls and 98 boys. The median age at onset and operation was 3 years and 5 years, respectively. Endoscopic-assisted surgery was performed in 143 patients. During the same period, RA was performed in 48 patients, and 10 of them concurrently underwent incision and drainage of neck abscesses. Longer hospital stay was found in the endoscopic-assisted surgery group than in the RA group (10.50 ± 3.93 vs. 5.02 ± 3.30 days, P < 0.001). Postoperative complications were not significantly different between the two groups, except for neck infection (0 vs. 8.3%, P = 0.004). After a median follow-up period of 21 months, no significant difference was found between the two groups in terms of recurrence (1.4% vs. 0, P = 0.560).ConclusionPatients treated with RA had a significantly shorter hospital stay than those treated with endoscopic-assisted surgery. Outcomes of endoscopic-assisted surgery and RA were not significantly different for the management of PSF and treatment method should be tailored to the patient.Level of evidenceIV. 相似文献