全文获取类型
收费全文 | 160205篇 |
免费 | 14946篇 |
国内免费 | 10593篇 |
专业分类
耳鼻咽喉 | 1614篇 |
儿科学 | 2293篇 |
妇产科学 | 1375篇 |
基础医学 | 15614篇 |
口腔科学 | 2834篇 |
临床医学 | 18614篇 |
内科学 | 22758篇 |
皮肤病学 | 1696篇 |
神经病学 | 7752篇 |
特种医学 | 6420篇 |
外国民族医学 | 56篇 |
外科学 | 17460篇 |
综合类 | 31194篇 |
现状与发展 | 45篇 |
一般理论 | 12篇 |
预防医学 | 13320篇 |
眼科学 | 3238篇 |
药学 | 16861篇 |
177篇 | |
中国医学 | 10033篇 |
肿瘤学 | 12378篇 |
出版年
2024年 | 567篇 |
2023年 | 2110篇 |
2022年 | 5375篇 |
2021年 | 7338篇 |
2020年 | 5562篇 |
2019年 | 4570篇 |
2018年 | 4762篇 |
2017年 | 4946篇 |
2016年 | 4754篇 |
2015年 | 7325篇 |
2014年 | 9060篇 |
2013年 | 9120篇 |
2012年 | 13541篇 |
2011年 | 14417篇 |
2010年 | 10891篇 |
2009年 | 9304篇 |
2008年 | 10612篇 |
2007年 | 10337篇 |
2006年 | 9411篇 |
2005年 | 8480篇 |
2004年 | 6250篇 |
2003年 | 5887篇 |
2002年 | 4988篇 |
2001年 | 3355篇 |
2000年 | 2739篇 |
1999年 | 2061篇 |
1998年 | 1290篇 |
1997年 | 1254篇 |
1996年 | 927篇 |
1995年 | 868篇 |
1994年 | 710篇 |
1993年 | 440篇 |
1992年 | 450篇 |
1991年 | 387篇 |
1990年 | 292篇 |
1989年 | 237篇 |
1988年 | 230篇 |
1987年 | 188篇 |
1986年 | 159篇 |
1985年 | 108篇 |
1984年 | 78篇 |
1983年 | 55篇 |
1982年 | 46篇 |
1981年 | 33篇 |
1980年 | 28篇 |
1979年 | 27篇 |
1978年 | 28篇 |
1975年 | 19篇 |
1973年 | 19篇 |
1972年 | 21篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
改良开放性手术治疗巨大良性前列腺增生症 总被引:2,自引:0,他引:2
目的探讨巨大良性前列腺增生症的开放性手术治疗方法及效果。方法回顾分析16例巨大良性前列腺增生症,年龄61~88岁,平均74岁。作耻骨上经膀胱前列腺切除术。结果手术均成功;手术时间35~65min,出血量100~200mL,术后前列腺重量为200~520g,平均215g;膀胱冲洗2~3d,拔导尿管5~7d;术后3d再出血1例,经DSA同侧髂内血管栓塞止血成功,排尿困难1例,短期尿失禁1例,其余患者术后均排尿通畅,控尿良好。结论开放性手术治疗巨大良性前列腺增生症,其梗阻解除彻底,是一种合理的治疗方法。恰当的手术方法是提高疗效及降低并发症的关键。 相似文献
52.
We thank Drs Liu and Li for their interest in our randomizedtrial investigating the anti-arrhythmic effect of perindopriland losartan in the setting of lone paroxysmal atrial fibrillation(AF). While agreeing on modification of atrial remodelling asthe 相似文献
53.
目的检测瘢痕疙瘩、增生性瘢痕和正常皮肤组织中转化生长因子-β1(TGF-β1)、Smad3和P-Smad2/3的表达情况,探讨上述细胞因子对瘢痕产生的重要性及影响。方法采用免疫组织化学的方法检测上述3种细胞因子在3种不同组织共36例标本中的表达,ImagePro-Plus6.0软件进行阳性面积测量和细胞计数。结果TGF-β1在瘢痕疙瘩和增生性瘢痕中均为增强高表达,而在正常皮肤中几乎不表达;Smad3在三组标本间表达水平无显著性差异;P-Smad2/3在瘢痕疙瘩中表达最强,增生性瘢痕次之,正常皮肤组织中最低。结论TGF-β1表达增强是病理性瘢痕产生的重要原因,P-Smad2/3的表达水平则可认为与瘢痕增生程度密切相关。 相似文献
54.
Kazuaki Shimamoto Toru Kita Hiroshi Mabuchi Masunori Matsuzaki Yuji Matsuzawa Noriaki Nakaya Shinichi Oikawa Yasushi Saito Jun Sasaki Hiroshige Itakura 《Hypertension research》2007,30(2):119-123
Hyperlipidemia, hypertension, and diabetes mellitus (DM) are well-established risk factors for cardiovascular disease. We analyzed the cardiovascular events in hyperlipidemic patients with or without DM who were administered open-labeled simvastatin in groups stratified by blood pressure level using data from the Japan Lipid Intervention Trial (J-LIT). Hyperlipidemic patients with DM (n=6,288) had significantly more cardiovascular events than those without DM (n=33,933). The incidence rates of total cardiovascular events in the Non-DM and DM groups were 15.40 and 25.76 per 1,000 patients for the 6-year period, respectively. The relative risk of total cardiovascular events in the DM vs. the Non-DM group was 1.68, and the relative risk was significantly higher in the DM than in the Non-DM group. The relative risks of total cardiovascular events were significantly higher in DM and Non-DM patients whose systolic blood pressure (SBP) was greater than or equal to 130 mmHg compared to that of Non-DM patients whose SBP was less than 130 mmHg, and in DM and Non-DM patients whose diastolic blood pressure (DBP) was greater than or equal to 80 mmHg compared to that of Non-DM patients whose DBP was less than 80 mmHg. In all groups stratified by SBP and DBP, relative risks of total cardiovascular events were higher in DM patients than in Non-DM patients. For patients with hypercholesterolemia and DM, blood pressure should be strictly controlled in order to prevent both coronary events and stroke. These results are in good agreement with the JNC 7 and the ESH/ESC guidelines for DM patients, which recommended that the SBP and DBP be less than 130 and 80 mmHg, respectively. 相似文献
55.
56.
Objective
To investigate an initial approach of radiotherapy, which produces cellular radiation injury by high dose in one fraction. 相似文献57.
Hiroko Utsunomiya Wanninayake M. Tilakaratne Kazufumi Oshiro Satoshi Maruyama Makoto Suzuki Hiroko Ida-Yonemochi Jun Cheng Takashi Saku 《Journal of oral pathology & medicine》2005,34(8):498-507
BACKGROUND: Oral submucous fibrosis (OSF) is a chewing habit-related pre-cancerous condition of the oral mucosa affecting predominantly south Asians. It is histopathologically characterized by epithelial atrophy and fibrosis of the subepithelial connective tissue. Fibrosis extends all the way into the muscle layer, leading to difficulty in mouth opening. However, the dynamics of extracellular matrix (ECM) remodeling with OSF progression is largely unknown. METHODS: Forty biopsy specimens of OSF and 10 of normal buccal mucosa were examined for expression/deposition modes of eight ECM molecules by histochemistry, immunohistochemistry, and in situ hybridization. RESULTS: In the early stage of OSF, tenascin, perlecan, fibronectin, collagen type III were characteristically enhanced in the lamina propria and the submucosal layer. In the intermediate stage, the ECM molecules mentioned above and elastin were extensively and irregularly deposited around muscle fibers. In the advanced stage, such ECM depositions decreased and were entirely replaced with collagen type I only. Their gene expression levels varied with progression of fibrosis, but the mRNA signals were confirmed in fibroblasts in the submucosal fibrotic areas. CONCLUSIONS: The results indicate that the ECM remodeling steps in OSF are similar to each phase of usual granulation tissue formation. Restricted mouth opening may be a result of loss of variety of ECM molecules including elastin into the homogeneity of collagen type I replacing muscle fibers. 相似文献
58.
综合疗法治疗乳腺增生62例 总被引:1,自引:0,他引:1
我科于2005年6月~2006年12月用乳癖消结合逍遥丸内服、耳穴埋压治疗乳腺增生62例,获得满意疗效,现介绍如下。 相似文献
59.
特异性荧光偏振免疫法监测521例肾移植后环孢素A全血浓度3275次 总被引:2,自引:0,他引:2
目的通过监测肾移植后病人环孢素A(CsA)全血浓度 ,提出CsA在三联免疫抑制用药方案中的理想治疗窗。方法用特异性荧光偏振免疫法测定CsA全血浓度 ,对521例病人监测3275次 ,按术后时间及临床表现分组比较。结果肾移植后<1 ,、1~3、3~6、6~12个月、1~2和>2年的CsA全血谷浓度的理想治疗窗应分别为250~450、200~400、150~300、100~250、100~200和100~180μg/L。结论CsA全血浓度在上述范围内 ,中毒反应和排异反应明显减少 相似文献
60.
用自制液压冲击颅脑损伤仪对大鼠的头部由轻到重的4种冲击力产生4级脑损伤。1级可以无明显病理生理变化;2~4级则随冲击力的加重病理生理变化亦加重。这些变化包括心率,呼吸,血压,颅内压,脑水份含量与伊文思蓝蓝染范围测定以及病理学的变化。 相似文献