全文获取类型
收费全文 | 7162篇 |
免费 | 301篇 |
国内免费 | 50篇 |
专业分类
耳鼻咽喉 | 80篇 |
儿科学 | 141篇 |
妇产科学 | 92篇 |
基础医学 | 821篇 |
口腔科学 | 198篇 |
临床医学 | 405篇 |
内科学 | 1738篇 |
皮肤病学 | 152篇 |
神经病学 | 421篇 |
特种医学 | 343篇 |
外科学 | 1333篇 |
综合类 | 17篇 |
一般理论 | 1篇 |
预防医学 | 175篇 |
眼科学 | 136篇 |
药学 | 430篇 |
中国医学 | 6篇 |
肿瘤学 | 1024篇 |
出版年
2023年 | 33篇 |
2022年 | 70篇 |
2021年 | 146篇 |
2020年 | 79篇 |
2019年 | 115篇 |
2018年 | 160篇 |
2017年 | 124篇 |
2016年 | 163篇 |
2015年 | 166篇 |
2014年 | 231篇 |
2013年 | 247篇 |
2012年 | 393篇 |
2011年 | 482篇 |
2010年 | 285篇 |
2009年 | 225篇 |
2008年 | 402篇 |
2007年 | 415篇 |
2006年 | 415篇 |
2005年 | 385篇 |
2004年 | 407篇 |
2003年 | 392篇 |
2002年 | 375篇 |
2001年 | 136篇 |
2000年 | 118篇 |
1999年 | 149篇 |
1998年 | 102篇 |
1997年 | 100篇 |
1996年 | 75篇 |
1995年 | 58篇 |
1994年 | 65篇 |
1993年 | 60篇 |
1992年 | 87篇 |
1991年 | 109篇 |
1990年 | 83篇 |
1989年 | 71篇 |
1988年 | 75篇 |
1987年 | 75篇 |
1986年 | 68篇 |
1985年 | 63篇 |
1984年 | 51篇 |
1983年 | 32篇 |
1982年 | 18篇 |
1981年 | 21篇 |
1980年 | 10篇 |
1979年 | 22篇 |
1978年 | 23篇 |
1977年 | 13篇 |
1975年 | 10篇 |
1973年 | 16篇 |
1972年 | 12篇 |
排序方式: 共有7513条查询结果,搜索用时 15 毫秒
61.
62.
Kouji Katsura Yoshihiko Soga Sadatomo Zenda Hiromi Nishi Marie Soga Masatoshi Usubuchi Sachiyo Mitsunaga Ken Tomizuka Tetsuhito Konishi Wakako Yatsuoka Takao Ueno Tadanobu Aragaki Takafumi Hayashi 《Journal of radiation research》2021,62(2):374
The aim of this study was to compare the estimated public medical care cost of measures to address metallic dental restorations (MDRs) for head and neck radiotherapy using high-energy mega-voltage X-rays. This was considered a first step to clarify which MDR measure was more cost-effective. We estimated the medical care cost of radiotherapy for two representative MDR measures: (i) with MDR removal or (ii) without MDR removal (non-MDR removal) using magnetic resonance imaging and a spacer. A total of 5520 patients received head and neck radiation therapy in 2018. The mean number of MDRs per person was 4.1 dental crowns and 1.3 dental bridges. The mean cost per person was estimated to be 121 720 yen for MDR removal and 54 940 yen for non-MDR removal. Therefore, the difference in total public medical care cost between MDR removal and non-MDR removal was estimated to be 303 268 800 yen. Our results suggested that non-MDR removal would be more cost-effective than MDR removal for head and neck radiotherapy. In the future, a national survey and cost-effectiveness analysis via a multicenter study are necessary; these investigations should include various outcomes such as the rate of local control, status of oral mucositis, frequency of hospital visits and efforts of the medical professionals. 相似文献
63.
Summary Using SPECT, the time course of brain uptake was compared between N-isopropyl-p-[I-123]-iodoamphetamine (I-123 IMP) and Tc-99m d,l hexamethyl-propyleneamine oxime (Tc-99m HM-PAO). Of 14 patients with cerebrovascular disease showing areas of the filling-in phenomenon (i.e. delayed uptake) with I-123 IMP brain SPECT, 7 exhibited persistent defects with Tc-99m HM-PAO (Group I), and 7 showed early washout after the initial uptake (Group II). The filling-in of I-123 IMP did not always correlate to the washout region of Tc-99m HM-PAO. The temporal changes were also confirmed by semiquantitative analysis. While the filling-in of I-123 IMP was affected by many factors, the washout of Tc-99m HM-PAO was attributed to significant reduction of Tc-99m HM-PAO in the plasma. Delayed imaging of the brain with Tc-99m HM-PAO using SPECT may give a more accurate estimate of regional cerebral blood flow in cerebrovascular disease, because it should be lees effected by cerebral blood volume. 相似文献
64.
We evaluated three solutions used for preserving lungs, namely, University of Wisconsin (UW), Euro-Collins (E-C), and low potassium dextran (LPD), by measuring the high energy phosphates in the preserved lung tissue. The left lungs of Sprague-Dawley rats were excised and flushed with 5 ml of one of the solutions at 10°C through the pulmonary artery, after which they were deflated and immersed in the solution at 10°C for 24 h. The tissue adenosine triphosphate (ATP) concentration in mol/g tissue wet weight after 24 h of storage was 2.55 ± 0.48 (n = 7) in the UW lungs, 1.98 ± 0.25 (n = 6) in the E-C lungs, and 1.53 ± 0.32 (n = 4) in the LPD lungs, being significantly higher in the UW lungs than in either the E-C or LPD lungs (P < 0.05). The histopathological findings of the E-C lungs were more deteriorated, with marked interstitial edema, septal hypertrophy, and perivascular hyaline degeneration, than either the UW or LPD lungs. Thus, the findings of this study indicate the superiority of UW solution for lung preservation. 相似文献
65.
A rare complication of upward migration of the L-P shunt catheter into the cranial base is reported. A 59-year-old female with hydrocephalus underwent L-P shunt with a one-piece catheter. The catheter was secured with a clip but migrataed up to the cranial base without the clip becoming detached from the catheter. We assume that the catheter slipped at the position of the clip as the result of a strong force produced by lumbar movements, and that the clip may have acted like an one-way valve to push the catheter into the spinal canal. To prevent such a complication, we should tighten the clip as firmly as possible and use more clips, or use another type of clip which prevents slipping of a one-piece catheter such as the one described by Imaizumi et al. 相似文献
66.
Inoue Y Katayama N Yoshioka N Yoshikawa K Kashima M Shimizu T Tsukune Y Ohtomo K 《Annals of nuclear medicine》1999,13(6):453-456
The aim of this study was to evaluate breast parenchymal activity on scintimammography with bone-seeking agents and 99mTc-MIBI. Scintimammography was performed with bone-seeking agents in 61 patients and with 99mTc-MIBI in 33 patients. Activity in the breast parenchyma contralateral to the suspected lesion was visually assessed by two independent observers. Increased breast parenchymal activity was shown in 19 of 61 patients examined with bone-seeking agents, while it was demonstrated in only two of 33 patients examined with 99mTc-MIBI. Breast parenchymal activity of bone-seeking agents was higher in patients aged 50 years or younger than in those older than 50. Increased parenchymal activity of bone-seeking agents may disturb visualization of primary breast cancer especially in relatively young patients. Low parenchymal activity is suggested to be a favorable characteristic of 99mTc-MIBI as a scintimammographic agent. 相似文献
67.
The results of surgical treatment for a ruptured type B aortic dissection remain far from satisfactory. It is believed that
additional perfusion from the right axillary artery might be more beneficial than perfusion from only the femoral artery during
surgery for a ruptured thoracic aneurysm. The right axillary perfusion is more likely to perfuse the vital organs proximal
to the ruptured area, and thus avoid retrograde emboli. In addition, if the open proximal method is performed, then the right
axillary perfusion is able to facilitate the evacuation of air from the aortic lumen. We present herein the case of a patient
in whom a ruptured type B acute aortic dissection was successfully treated by applying right axillary perfusion through a
left thoracotomy. 相似文献
68.
Ichinose Y Okino T Yamasaki S Moriguchi Y Sugie T Li L Kanaoka S Kan N Watanabe Y Imamura M 《Surgery today》1999,29(4):338-343
To evaluate the effect of interferon-γ-genetransduced cells, DS mice were inoculated into their footpads with syngeneic mammary
adenocarcinoma SC42 admixed with interferon-γ producing mammary adenocarcinoma SC115Kγ, which had been established by an interferon-γ-gene
transduction in another syngeneic mammary adenocarcinoma SC115 using retroviral vectors. These mice rejected both tumor cells
and developed resistance to subsequent challenges with either SC115 or SC42 cells inoculated into their opposite posterior
footpads. These results thus indicate that systemic immunological memory to each of the independent tumor cell lines developed
in these mice. Although the SC42 cells admixed with irradiated SC115Kγ cells were rejected by these mice, the SC42 cells admixed
with irradiated SC115neoR, in which the neo-gene had been transduced, were observed to proliferate. Tumor rejection was reversed
by an in vivo administration of anti-interferon-γ antibody, thus suggesting that locally produced interferon-γ plays an important
role in tumor elimination and immunological memory induction. In conclusion, interferon-γ-gene-transduced tumor cells are
therefore considered to have a therapeutic potential for other types of malignant tumor cell lines. 相似文献
69.
Inagaki M Yabuki H Hashimoto M Maguchi M Kino S Sawa M Ojima H Tokusashi Y Miyokawa N Kusano M Kasai S 《Surgery today》1999,29(12):1260-1263
We describe herein the case of a 51-year-old woman in whom metastatic tumor seeding of the percutaneous transhepatic biliary
drainage tract occurred following a pancreatoduodenectomy for carcinoma of the distal common bile, duct. An abdominal computed
tomography scan done 6 months after the initial operation detected a hepatic lesion located at the site of the previous percutaneous
transhepatic biliary drainage tract. Implantation of bile duct carcinoma in the drainage tract was diagnosed, and the recurrent
tumor was successfully resected by performing a subsegmentectomy of segment 3 and removal of the adjacent abdominal wall.
At present, 5 years and 4 months after the second resection, the patient is in good health without any signs of recurrence.
This case report demonstrates that an aggressive surgical approach should be performed for tumor seeding of a transhepatic
biliary catheter tract. 相似文献
70.
When the diaphragm is excised so wiely that the defect cannot be closed directly during an operation on either thoracic or
epigastric tumors, a reconstruction of the defect is necessary. We used harvested autologous fascia lata to reconstruct the
diaphragm in a patient undergoing a pleuropneumonectomy with a partial diaphragmatic resection for malignant mesothelioma. 相似文献