全文获取类型
收费全文 | 7135篇 |
免费 | 321篇 |
国内免费 | 50篇 |
专业分类
耳鼻咽喉 | 80篇 |
儿科学 | 141篇 |
妇产科学 | 92篇 |
基础医学 | 821篇 |
口腔科学 | 198篇 |
临床医学 | 404篇 |
内科学 | 1733篇 |
皮肤病学 | 152篇 |
神经病学 | 421篇 |
特种医学 | 343篇 |
外科学 | 1333篇 |
综合类 | 17篇 |
一般理论 | 1篇 |
预防医学 | 175篇 |
眼科学 | 136篇 |
药学 | 430篇 |
中国医学 | 6篇 |
肿瘤学 | 1023篇 |
出版年
2023年 | 30篇 |
2022年 | 68篇 |
2021年 | 146篇 |
2020年 | 79篇 |
2019年 | 115篇 |
2018年 | 160篇 |
2017年 | 124篇 |
2016年 | 163篇 |
2015年 | 166篇 |
2014年 | 231篇 |
2013年 | 247篇 |
2012年 | 393篇 |
2011年 | 482篇 |
2010年 | 285篇 |
2009年 | 225篇 |
2008年 | 402篇 |
2007年 | 415篇 |
2006年 | 415篇 |
2005年 | 385篇 |
2004年 | 407篇 |
2003年 | 392篇 |
2002年 | 375篇 |
2001年 | 136篇 |
2000年 | 118篇 |
1999年 | 149篇 |
1998年 | 102篇 |
1997年 | 100篇 |
1996年 | 75篇 |
1995年 | 58篇 |
1994年 | 65篇 |
1993年 | 60篇 |
1992年 | 87篇 |
1991年 | 109篇 |
1990年 | 83篇 |
1989年 | 71篇 |
1988年 | 75篇 |
1987年 | 75篇 |
1986年 | 68篇 |
1985年 | 63篇 |
1984年 | 51篇 |
1983年 | 32篇 |
1982年 | 18篇 |
1981年 | 21篇 |
1980年 | 10篇 |
1979年 | 22篇 |
1978年 | 23篇 |
1977年 | 13篇 |
1975年 | 10篇 |
1973年 | 16篇 |
1972年 | 12篇 |
排序方式: 共有7506条查询结果,搜索用时 265 毫秒
21.
K Hayashida T Nishimura Y Hirose T Kaminaga S Imakita T Uehara 《European journal of nuclear medicine》1992,19(11):987-989
A case of Takayasu's disease in a 22-year-old woman who complained of severe fainting attacks is presented. Bilateral obstruction of the cervical arteries was confirmed by digital subtraction angiography. Preoperative technetium-99m hexamethylpropylene amine oxime brain SPET in the sitting position showed bilateral hypoactivity in the temporoparietal areas. Subtraction brain SPET showed slightly increased activity in the lying position. The patient has had no fainting attacks since bypass surgery. Postoperative 99mTc-HMPAO brain SPET in the sitting position showed normal activity except in the right temporoparietal area. This area was filled in the lying position. 99mTc-HMPAO brain SPET is the only technique that can visualize the cerebral blood flow in any position, this capability deriving on the fact that the distribution of 99mTc-HMPAO in the brain is fixed in the first 2-3 min following injection. The use of both sitting and lying 99mTc-HMPAO brain SPET is very useful for detecting an abnormality (i.e. an inhomogeneous response due to the fall in perfusion pressure) that could not be seen if the cerebral blood flow were to be assessed only in the lying position. 相似文献
22.
23.
24.
Hideaki Anai Yoshihiko Maehara Tatsuo Oshiro Hideo Baba Hiroyuki Orita Toshiro Okuyama Keizo Sugimachi 《Journal of surgical oncology》1993,53(3):204-207
In 268 of the 1,115 patients (24.0%) with gastric cancer who underwent a curative resection in our clinics, the tumor was located in the middle third of the stomach. The clinicopathological features and prognosis of these patients were divided into two groups, according to site of the tumor: anterior wall (n = 58) vs. other sites (n = 210). Clinicopathological factors did not differ between the two groups. The survival time for patients with a tumor in the anterior group was shorter than that for patients with a tumor in other areas (P < 0.05). The five-year survival rate was 79.3% for patients with an anterior tumor and 91.9% for those with a tumor at a different site. A multivariate analysis indicated lymph node metastasis, serosal invasion, and anterior wall location to be independent prognostic factors indicative of a poor prognosis when the tumor was located in the middle third of the stomach. For such patients, close follow-up is needed to detect possible recurrences. © 1993 Wiley-Liss, Inc. 相似文献
25.
Hiroyasu Sakai Shinobu Otogoto Yoshihiko Chiba Kazuho Abe Miwa Misawa 《Journal of Smooth Muscle Research》2004,40(1):25-34
While nonspecific airway hyperresponsiveness (AHR) is a central feature of allergic bronchial asthma, the mechanism underlying the development of AHR is not clearly understood. We have previously demonstrated in vitro hyperresponsiveness of bronchial smooth muscle to acetylcholine (ACh) in rats that were actively sensitized and repeatedly challenged with aerosolized antigen. It has also been demonstrated that the ACh-induced, RhoA-mediated Ca(2+) sensitization is markedly augmented concomitantly with an increased expression and activation of RhoA protein in the bronchial smooth muscle of the antigen-treated rats. In the present study, we have investigated whether TNF-alpha, a proinflammatory cytokine which is involved in bronchial asthma, causes upregulation of RhoA mRNA and protein in the rat bronchus. Treatment of rat bronchial smooth muscle preparations with TNF-alpha (300 ng/ml for 24 hr) significantly shifted the concentration-response curve to ACh upwards, but did not alter the response to high K(+), when compared to that of control tissues. Levels of RhoA mRNA and protein in the TNF-alpha-treated bronchus were significantly greater than those in the control group. In conclusion, it is suggested that the augmentation of the ACh-induced contractile response evoked by TNF-alpha might be mediated by an upregulation of RhoA in rat bronchial smooth muscle. 相似文献
26.
Hideki Aragane Hideki Fujii Takaharu You Atuhiro Morita Morimichi Miyazaki Kiyoshi Morita Tohru Ohkawara Shinji Fukumitu Yoshihiko Sawa Yasuo Ohkawara 《Nihon Shokakibyo Gakkai zasshi》2006,103(5):537-542
This report describes our experience with a 60 year old male who suffered from a recrudescence of groove pancreatitis. He had been treated by conservative medication therapy by proton pump inhibitor used for therapy of duodenal ulcer, and was in remission. During a follow-up one year later, endoscopy revealed gastric cancer, for which a proximal gastrectomy and vagotomy were performed. The patient continues to remain in remission for the groove pancreatitis. Our experience with the clinical course of this disease, in which treatment for duodenal ulcer was used effectively, offers new insights into the progression and therapy of groove pancreatitis. 相似文献
27.
Dr. Shosaku Nakahara M.D. Hideaki Itoh M.D. Ryuichi Mibu M.D. Shinichi Ikeda M.D. Yoshihiro Oohata M.D. Kamesaburo Kitano M.D. Yoshihiko Nakamura M.D. 《Diseases of the colon and rectum》1988,31(10):762-766
Anorectal function was evaluated in eight patients who had low anterior resection of the rectum with a low anastomotic line,
using an EEA™ stapler, with determination of function based on periodic manometric studies and clinical symptoms. Immediately following
surgery all patients suffered from frequent bowel actions and soiling. These symptoms improved with time and most patients
could enjoy almost normal daily life by the sixth postoperative month. One month after surgery, anal canal resting pressure
and maximum squeeze pressure were significantly reduced and rectoanal inhibitory reflex was absent; neither showed a distinct
tendency to improve thereafter. Rectal sensation and reservoir capacity, which also were seriously impaired, recovered satisfactorily
by the time of the six-month examination. This suggests that an improvement of clinical symptoms following this operation
is dependent upon the recovery of reservoir capacity and sensation of the neorectum, and that this operative procedure is
a functionally acceptable option for low rectal cancer. 相似文献
28.
In mitral valve disease, it is important to know whether thrombi are present in the left atrium when deciding upon a course of treatment. The left atrial thrombus usually locates in the left atrial appendage. In most cases of mitral valve disease, the left atrial appendage is clearly demonstrated by radionuclide angiography using 99mTc-labeled red blood cells and it can be speculated that the cases in which left atrial appendage are not demonstrated by RNA have left atrial thrombi. On the basis of this hypothesis, the diagnostic accuracy of radionuclide angiography to detect left atrial thrombi was evaluated retrospectively in 60 patients with mitral valve disease who had undergone surgery. The sensitivity of first-pass and equilibrium radionuclide angiography to detect left atrial thrombi was 83% and 67%, the specificity 79% and 54%, and the accuracy 80% and 57%, respectively. Although there were two false-negative cases in which the left atrial thrombi did not locate in the appendage and 10 false-positive cases in which left atrial appendages were not dilated, the negative predictive value was so high that a clearly demonstrated left atrial appendage can be translated into the absence of left atrial thrombi. 相似文献
29.
Tissue specimens from patients with the scirrhous type of gastric carcinoma were stained using the peroxidase-antiperoxidase (PAP) method. Nine out of thirty-seven specimens (24 per cent) showed positive estrogen staining, and here tissues from male or older patients were usually stained. Cumulative survival rate in patients whose tissue showed a positive estrogen staining was higher than that in case of a negative estrogen staining. Four out of thirty-one specimens (13 per cent) stained positively for progesterone, all four patients being male. These results suggest that estrogen and progesterone may relate to the growth of the scirrhous type of gastric cancer. 相似文献
30.
K Tsuji A Uehara T Okumura Y Taniguchi S Kitamori Y Takasugi M Namiki 《European journal of pharmacology》1992,210(2):213-215
We have recently found that bacterial lipopolysaccharide (LPS) at minute doses inhibits the secretion of gastric acid and pepsin in rats. The present study was performed to examine the mechanism by which LPS exerts its antisecretory action. The i.p. injection of LPS resulted in a dose-dependent (40-4000 ng/kg) decrease in gastric acid output in pylorus-ligated rats. However, preinjection of indomethacin (2-10 mg/kg s.c.), an inhibitor of prostaglandin biosynthesis, prevented the LPS-induced inhibition of gastric secretion in a dose-related manner, while these concentrations of indomethacin by themselves did not affect gastric acid output. These results suggest that LPS requires an intact prostaglandin system to exhibit its inhibitory action on gastric secretion. 相似文献