一种中西药复方制剂(PESM)对大鼠实验性肾结石形成的抑制作用

用乙二醇法诱导大鼠产生草酸钙结石，用45~Ca示踪测定法了解中草药复方制剂（PESM）对草酸钙结石形成的抑制作用。结果显示，实验组肾脏放射性强度明显减少（实验组3.47±3.52cpm／mg，对照组10.89±14.24cpm／mg）。干肾重量明显下降（实验组306.0±47.0mg，对照组343.1±59.4mg），说明PESM能明显抑制肾脏草酸钙结石的形成。     

~（99m）Tc－新半乳糖白蛋白体外受体介导结合特性的研究

本文报道￣９９ｍＴｃ－新半乳糖白蛋白（￣９９ｍＴｃ－ＮＧＡ）与大鼠肝细胞膜进行体外结合试验。结果表明：￣９９ｍＴｃ－ＮＧＡ系与肝细胞膜上的高亲和力低容量（Ｋ＿１：８．４０８９×１０￣９Ｌ／ｍｏｌ；Ｒ＿１：１．７３５０×１０￣（－１２）ｍｏｌ／ｍｇ）和低亲和力高容量（Ｋ＿２：２．０８２７×１０￣８Ｌ／ｍｏｌ；Ｒ＿２：６．９５３０×１０￣（－１２）ｍｏｌ／ｍｇ）２个结合位点相结合，其结合表现出高特异性、可饱和性及对细胞膜蛋白浓度的线性依赖性，具备受体介导结合的基本特征。￣（９９ｍ）Ｔｃ－ＮＧＡ是一个很有希望的肝受体显像剂。     

A study on various symptoms of chronic hepatitis treated with radix astragali and its regulative effect to levels of serum hormone

Sixty-seven cases of chronic hepatitis were treated with Radix Astragali. After treatment (2-month course), the clinical improvement rate in 38 cases of the Stagnation of the Liver-Qi and Deficiency of the Spleen type was 92.1%, and in 26 cases of the Deficiency of Liver Yin and Kidney Yin type was 88.5%, more effective than in the control group (P<0.05). The regulative effect to the levels of serum hormone was observed in the patients of the Stagnation of the Liver-Qi and Deficiency of the Spleen type treated with this medicine. The results showed that the levels of serum triiodothyronine, estradiol (female) and testosterone (male) were increased after treatment (1.40±1.38 ng/dl, 129.30±1.23 pg/ml and 496.24±1.47 ng/dl). Pre-treatment levels were 1.22±1.49 ng/dl, 104.60±1.45 pg/ml and 398. 17±1.55 ng/dl respectively (P<0.05); however, the level of serum prolactin (2.75±4.46 ng/ml) was lower after treatment than before treatment (3.20±3.82 ng/ml,P<0.05). No obvious changes were observed in the levels of serum follicle stimulating hormone, luteinizing hormone, thyroid stimulating hormone, thyroxine, triiodothyronine uptake ratio and cortisol after treatment.     

同种异体原位心脏移植成功3例报告

目的:总结分析3例同种异体原位心脏移植术的临床经验。方法:采用Shumway&Stanford方法对3例终末期扩张型心肌病病人行同种异体原位心脏移植术。其中1例伴有严重糖尿病和中度肺动脉高压,术前心跳骤停心肺复苏成功;1例极度肥胖,体重108kg(身高172cm);1例62岁高龄伴肾功能不全和中度肺动脉高压。供体均为脑死亡者,供心保护采用4℃改良StThomas液;术后免疫抑制治疗采用环孢素A、骁悉、强的松三联治疗,根据血环孢素浓度及心内膜活检调整环孢素A用量。结果:3例均康复,未发生术后超急性或急性排斥反应。例2术后出现一过性右心功能不全,经大量利尿和无创通气治疗,48h后完全恢复;例3术后并发急性肾功能衰竭和肺部感染,经连续肾脏替代(CRRT)和调整抗生素治疗痊愈。病人心功能均恢复正常。例1需长期胰岛素治疗糖尿病。3例均完全过上了正常人的生活,2例已恢复手术前工作。结论:同种异体原位心脏移植是治疗终末期心脏病的有效方法。     

吡那地尔对体外培养大鼠大脑皮层神经细胞缺氧缺糖损伤的保护作用

目的 :探讨ATP敏感性K+ 通道 (KATP)开放剂吡那地尔 (pinacidil,Pin)对缺氧缺糖再复氧损伤大鼠大脑皮层神经细胞的保护作用。方法 :体外培养大鼠大脑皮层神经细胞 ,细胞培养至 10d ,建立神经细胞缺氧缺糖损伤模型 ,观察Pin及KATP阻断剂格列苯脲对缺氧缺糖不同时间 ,再复氧 2 4h后细胞死亡率、丙二醛 (MDA)含量、超氧化物歧化酶 (SOD)活力的影响。结果 :缺氧缺糖、再复氧后大鼠的神经细胞死亡率均显著升高、MDA生成增多、SOD的活力下降 ,Pin干预后 ,细胞死亡率下降、MDA生成减少、SOD的活力升高 ;格列苯脲能拮抗Pin这种保护作用。结论 :Pin对缺氧缺糖损伤神经细胞具有保护作用 ,并与拮抗氧自由基有关     

强直性肌营养不良毛细血管的超微结构变化

５例强直性肌营养不良患者的腓肠肌活检标本超微结构研究结果发现，除肌纤维变性、萎缩和结缔组织增生外，毛细血管病变特别突出。血管壁严重增厚，基板呈多层性改变，周细胞增生。有些复层的毛细血管基板多达９层。内皮细胞外可有多层周细胞半包绕血管，有些周细胞又发出分支沿管壁延伸。周细胞一般位于内皮细胞下第一层基板之外，也可位于复层基板之中，周细胞与周细胞之间有多层基板。内皮细胞和周细胞内富含吞饮小泡。血管病变程度与肌纤维变性程度呈平行关系。     

荞麦花粉抗贫血作用的实验研究

用荞麦花粉的水提取液进行了抗大白鼠缺铁性贫血的研究，结果表明：荞麦花粉具有和硫酸亚铁相似的抗缺铁性贫血作用．饮用荞麦花粉提取液３５ｄ的大白鼠，生长发育良好，主要脏器未见损害．该研究为荞麦花粉的开发利用提供了实验依据．     

A clinical trial of the secondary prevention of reinfarction with low dose aspirin]

Patients with acute myocardial infarction (AMI) admitted between 1986 and 1989 were divided into aspirin (ASA) group (216 cases) and control group (211 cases). In ASA group, 50 mg ASA was given daily to each case from the early stage of AMI and continuously after discharge (follow-up in OPD). In control group, no antiplatelet agents were administered during the follow-up period. The other therapies were comparable in both groups. The patients in both groups were scheduled for examination in the OPD every one to two months after discharge. Both groups were followed up until July, 1990. The follow-up periods in ASA group and control group were 19.4 +/- 12.6 vs 20.7 +/- 13.0 months respectively. There were 312 men in this study (175 in ASA group and 137 in control group). In men, incidence of reinfarction was reduced by 65% (P less than 0.001) and platelet aggregation was inhibited obviously in ASA group as compared to control group. However, there were no statistically significant differences of reinfarction and platelet aggregation between ASA group and control group in women. Thus, it is evident that low dose ASA is effective in preventing reinfarction and inhibiting platelet aggregation in men.     

扩大经额硬膜外入路切除巨大侵袭性垂体瘤

目的:探讨采用扩大的经额硬膜外入路切除巨大侵袭性垂体瘤的临床应用.方法:1997年6月至2002年3月采用该入路显微外科切除巨大侵袭性垂体瘤10例,肿瘤主要累及于鞍上、蝶筛窦及上斜坡区.结果:本组10例中,肿瘤全切6例,次全切除3例,大部分切除1例.术后发生颅神经麻痹4例,其中动眼神经障碍3例,外展神经障碍1例.全组无手术死亡.术后影像学随访6～24个月,全切除肿瘤病例未见肿瘤复发,次全切除者无明显增大.结论:该入路可充分显露鞍区肿瘤,术野开阔,对脑组织损伤小,适用于已侵犯蝶筛窦区及上斜坡的侵袭性垂体瘤.