游离回盲肠移植修复下咽病人的护理

2005年2月我科采用游离回盲肠进行下咽颈段食管癌修复,术中升结肠端与下咽吻合,回肠端与气管吻合,阑尾端与食管吻合。其优点在于回盲瓣的结构与声带相似,术后可利用其瓣膜进行发音功能训练;利用回盲瓣是单项开放的瓣膜特性,可防止术后食物反流,发生误咽。该病人术后进食顺利,恢     

症状性大脑中动脉狭窄的脑梗死模式观察

目的：观察症状性动脉粥样硬化性大脑中动脉狭窄患者的脑梗死模式和分布，探讨动脉粥样硬化性大脑中动脉狭窄导致脑梗死的病理生理机制。方法：回顾性分析2004-06／2005-08在北京天坛医院脑血管病抢救治疗中心治疗的50例脑血管造影证实的症状性大脑中动脉狭窄患者的MRI影像学资料，所有患者狭窄率〉50％，不伴有同侧颈内动脉狭窄或闭塞，具有≥1个的动脉粥样硬化危险因素，对其脑梗死模式进行分类观察。结果：50例大脑中动脉狭窄患者的神经影像学资料分析显示，皮质下梗死最常见，其中深穿支梗死44％、内交界区梗死42％；皮质支梗死和区域性梗死各占6％和2％；散发皮质小梗死14％；外交界区梗死中前交界区梗死12％、后交界区梗死24％。结论：动脉粥样硬化性大脑中动脉狭窄可以表现为多种脑梗死模式，提示大脑中动脉狭窄导致脑梗死不同的病理生理机制。     

Neck Circumference Positively Related With Central Obesity, Overweight, and Metabolic Syndrome in Chinese Subjects With Type 2 Diabetes: Beijing Community Diabetes Study 4

OBJECTIVE

To investigate the association between neck circumference and central obesity, overweight, and metabolic syndrome in Chinese individuals with type 2 diabetes.

RESEARCH DESIGN AND METHODS

A total of 3,182 diabetic subjects (aged 20–80 years) were recruited from 15 community health centers in Beijing using a multistage random sampling approach.

RESULTS

Receiver operating characteristic analysis showed that the area under the curve for neck circumference and central obesity was 0.77 for men and 0.75 for women (P < 0.001). Furthermore, a neck circumference of ≥38 cm for men and ≥35 cm for women was the best cutoff point for determining overweight subjects. A neck circumference of ≥39 cm for men and ≥35 cm for women was the best cutoff point to determine subjects with metabolic syndrome.

CONCLUSIONS

In the present study, neck circumference is positively related with BMI, waist circumference, and metabolic syndrome in Chinese individuals with type 2 diabetes.Neck circumference (NC) as an index for upper-body subcutaneous adipose tissue distribution has been evaluated in relation to cardiovascular risk factors, insulin resistance, and biochemical components of metabolic syndrome (MS) (1–4). However, epidemiological population-based studies on the clinical significance of NC in connection with overweight and MS in diabetic people are lacking. The aim of this study was to determine whether NC alone can predict overweight and central obesity and to evaluate the association between NC and MS.     

重组人胰岛素样生长因子1的促糖代谢作用研究

目的 研究胰岛素样生长因子１对糖代谢的影响。方法 分别以Ｂａｌｂ／ｃ ３Ｔ３成纤维细胞和昆明种小鼠为对象,研究重组人胰岛素样生长因子１的降糖作用。结果 （１）ＩＧＦ１使Ｂａｌｂ／ｃ３Ｔ３细胞培养液和葡萄糖浓度降到对照组的６５％,与胰岛素的降糖能力相似;（２）ＩＧＦ１能使小鼠血糖降到正常值２０％左右,降糖作用呈剂量－效应曲线。     

A Novel Peptide from Polypedates megacephalus Promotes Wound Healing in Mice

Amphibian skin contains wound-healing peptides, antimicrobial peptides, and insulin-releasing peptides, which give their skin a strong regeneration ability to adapt to a complex and harsh living environment. In the current research, a novel wound-healing promoting peptide, PM-7, was identified from the skin secretions of Polypedates megacephalus, which has an amino acid sequence of FLNWRRILFLKVVR and shares no structural similarity with any peptides described before. It displays the activity of promoting wound healing in mice. Moreover, PM-7 exhibits the function of enhancing proliferation and migration in HUVEC and HSF cells by affecting the MAPK signaling pathway. Considering its favorable traits as a novel peptide that significantly promotes wound healing, PM-7 can be a potential candidate in the development of novel wound-repairing drugs.     

Comprehensive analysis of an autophagy-related prognostic model for predicting survival based on TCGA and ICGC database in hepatocellular carcinoma patients

BackgroundThere is accumulating evidence that autophagic activity is crucial to the development of hepatocellular carcinoma (HCC). Thus, we sought to develop a predictive model based on autophagy-related genes (ARGs) to forecast the prognosis of HCC patients.MethodsBased on expression data from The Cancer Genome Atlas (TCGA) and ARGs from Human Autophagy Database (HADb), the differentially expressed ARGs were screened. The prognosis-related ARGs were identified using a univariate Cox regression analysis. Using multivariate Cox regression analysis, a prognostic model was developed. To assess the predictive value of the model, receiver operating characteristic (ROC) curve, Kaplan-Meier curve, and multivariable Cox regression analyses were conducted. A data cohort gathered independently from the International Cancer Genome Consortium (ICGC) database further verified the model’s predictive accuracy. The immune landscape was generated using the TIMER and CIBERSORT algorithms. Finally, the correlation between the prognostic signature and gene mutation status was analyzed by employing “maftools” package.ResultsWe identified a novel prediction model based on the ARGs of PLD1 and SLC36A1 with significant prognostic values for HCC in both univariate and multivariate Cox regression analysis, and patients were classified into high- or low-risk groups based on their risk scores. High-risk patients had significantly shorter overall survival (OS) times than low-risk patients (P=5e-4). According to the ROC curve analysis, the risk score had a higher predictive value than the other clinical characteristics. Prognostic nomograms were also performed to visualize the relationship between individual predictors and survival rates in patients with HCC. Further, an external independent cohort of ICGC patients provided additional confirmation of the predictive efficacy of the model. We subsequently analyzed the differential immune densities of the two groups and discovered that various immune cells, including naïve B cells, resting memory cluster of differentiation (CD)4 T cells, regulatory T cells, M2 macrophages, and neutrophils, had considerably larger infiltrating densities in the high-risk group than the low-risk group.ConclusionsWe established a robust autophagy-related risk model having a certain prediction accuracy for predicting the prognosis of HCC patients. Our findings will contribute to the definition of prognosis and establishment of personalized treatment interventions for HCC patients.     

Wear Performance of Circular Shim against Cam in Engine Bench Test

Unlike the conventional engine, the valve train of a certain type of engine uses a circular shim instead of a tappet to wear against the cam. To verify the reliability of the shim, an engine bench test was used to test its wear performance. The total duration of the bench test was 1000 h, which was divided into three stages. In each stage, the test equipment was stopped, and the shims were disassembled to observe the surface morphology during the worn process. Precious long-term data were obtained. With the extension of the bench test time, weight loss increased. The maximum weight loss occurs 1000 h after worn, which is about twice that of 350 h. During the wear process, a plastic flow of material was found on the subsurface, and fatigue wear marks occurred on the surface. With an increase in test time, the wear marks increased, leading to material spalling and the formation of pits. The wear mechanism was the mixed wear of fatigue wear and adhesive wear.