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排序方式: 共有457条查询结果,搜索用时 31 毫秒
91.
Allen AM Mentzer SJ Yeap BY Soto R Baldini EH Rabin MS Sugarbaker DJ Bueno R 《Cancer》2008,112(5):1106-1113
BACKGROUND: The current study was conducted to examine the outcomes of pneumonectomy after induction chemoradiotherapy in patients with locally advanced nonsmall cell lung cancer (NSCLC). METHODS: All patients undergoing pneumonectomy after induction therapy at the Brigham and Women's Hospital were retrospectively evaluated for 30-day and 100-day mortality and treatment-related complications with Institutional Review Board approval. Multivariate and univariate analyses for clinical factors correlating with toxicity and/or survival were calculated. RESULTS: Between 1995 and 2005, 73 patients underwent pneumonectomy for NSCLC after induction therapy. All patients received radiation (median dose of 54 gray [Gy]) and 69 patients (95%) received concurrent chemotherapy. The median age was 62 years and 43 patients (59%) were male; Thirty-seven patients (51%) had American Joint Committee on Cancer stage IIIA NSCLC, 27 (37%) had stage IIIB, 6 had stage IIB, and 4 had stage IV NSCLC because of a resected solitary brain metastasis. A majority (44; 60%) of patients received the combination of carboplatin and paclitaxel, whereas 15 (21%) received the combination of cisplatin and etoposide. Forty-five patients (62%) underwent left pneumonectomy. With a median follow-up of 28 months, the 1-year and 2-year overall survival rates were 70% and 49%, respectively. The 30-day and 100-day mortality rates were 6% and 10%, respectively. Only 4 of 73 patients (6%) died of acute respiratory distress syndrome. The rate of nonfatal treatment-related morbidity was 11%. On univariate analysis, right-sided pneumonectomy was associated with a higher risk of treatment-related mortality (P = .099). CONCLUSIONS: With an acceptable mortality rate, a single-institutional series demonstrated that trimodality therapy including pneumonectomy can be safely accomplished in patients with advanced NSCLC. 相似文献
92.
Singapore Indian Eye Study‐2: methodology and impact of migration on systemic and eye outcomes
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The relationship between bone mineral density and ultrasound in postmenopausal and osteoporotic women 总被引:3,自引:0,他引:3
The aim of this cross-sectional study was to use a novel method of data analysis to demonstrate that patients with osteoporosis
have significantly lower ultrasound results in the heel after correcting for the effect of bone mineral density (BMD) measured
in the spine or hip. Three groups of patients were studied: healthy early postmenopausal women, within 3 years of the menopause
(n=104, 50%), healthy late postmenopausal women, more than 10 years from the menopause (n=75, 36%), and a group of women with osteoporosis as defined by WHO criteria (n=30, 14%). Broadband ultrasound attenuation (BUA), speed of sound (SOS) and Stiffness were measured using a Lunar Achilles
heel machine, and BMD of the lumbar spine and left hip was measured using dual-energy X-ray absorptiometry (DXA). SOS, BUA
and Stiffness were regressed against lumbar spine BMD and femoral BMD for all three groups combined. The correlation coefficients
were in the range 0.52–0.58, in agreement with previously published work. Using a calculated ratio R, analysis of variance
demonstrated that the ratio was significantly higher in the osteoporotic group compared with the other two groups. This implied
that heel ultrasound values are proportionately lower in the osteoporotic group compared with the other two groups for an
equivalent value of lumbar spine and femoral neck BMD. We conclude that postmenopausal bone loss is not associated with different
ultasound values once lumbar spine or femoral neck BMD is taken into account. Ultrasound does not give additional information
about patterns of bone loss in postmenopausal patients but is important in those patients with osteoporosis and fractures. 相似文献
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Histamine releasing activity of chandonium iodide and d-tubocurarine was studied in guinea pig ileum (in vitro), guinea pig peritoneum (in vivo) and in human volunteers (in vivo) by intradermal testing at dilutions of 1:1,000 and 1:10,000 of the clinical dosage of drugs. d-tubocurarine revealed significant histamine releasing activity in in vivo animal experiments and high incidence of positive intradermal reaction, 53.5 per cent and 13.5 per cent, in human volunteers. Chandonium iodide neither showed histamine releasing activity in animals nor in man. In clinical terms, chandonium iodide appears to be a safe neuromuscular blocking agent.KEY WORDS: Neuromuscular blocking agent, Histamine releasing activity, Chandonium iodide 相似文献
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Criticism of medical professionals is on the rise. The perception of the medical profession and the media, which educates the clientele, is widely different. The likely causes for dissatisfaction of the clientele and some possible solutions are presented.KEY WORDS: Armed Forces Medical Services, Medical care, Cost effective 相似文献
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