首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   172552篇
  免费   11802篇
  国内免费   552篇
耳鼻咽喉   2654篇
儿科学   4949篇
妇产科学   5117篇
基础医学   20910篇
口腔科学   5657篇
临床医学   24648篇
内科学   39696篇
皮肤病学   5008篇
神经病学   13022篇
特种医学   3655篇
外国民族医学   2篇
外科学   19662篇
综合类   994篇
一般理论   43篇
预防医学   16776篇
眼科学   3362篇
药学   10937篇
中国医学   872篇
肿瘤学   6942篇
  2023年   1726篇
  2022年   1739篇
  2021年   4354篇
  2020年   2628篇
  2019年   4118篇
  2018年   6674篇
  2017年   4629篇
  2016年   4538篇
  2015年   5002篇
  2014年   6242篇
  2013年   8569篇
  2012年   11195篇
  2011年   12288篇
  2010年   7127篇
  2009年   6038篇
  2008年   9580篇
  2007年   10010篇
  2006年   9316篇
  2005年   9180篇
  2004年   8214篇
  2003年   7611篇
  2002年   7030篇
  2001年   4846篇
  2000年   5228篇
  1999年   4285篇
  1998年   1399篇
  1997年   1320篇
  1996年   1162篇
  1995年   1023篇
  1994年   777篇
  1993年   630篇
  1992年   1737篇
  1991年   1474篇
  1990年   1356篇
  1989年   1101篇
  1988年   936篇
  1987年   865篇
  1986年   865篇
  1985年   779篇
  1984年   556篇
  1983年   480篇
  1979年   502篇
  1978年   346篇
  1975年   335篇
  1974年   413篇
  1973年   413篇
  1972年   410篇
  1971年   361篇
  1970年   326篇
  1969年   347篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
Chondrocytes are the main cells in the extracellular matrix (ECM) of articular cartilage and possess a highly differentiated phenotype that is the hallmark of the unique physiological functions of this specialised load-bearing connective tissue. The plasma membrane of articular chondrocytes contains a rich and diverse complement of membrane proteins, known as the membranome, which defines the cell surface phenotype of the cells. The membranome is a key target of pharmacological agents and is important for chondrocyte function. It includes channels, transporters, enzymes, receptors, and anchors for intracellular, cytoskeletal and ECM proteins and other macromolecular complexes. The chondrocyte channelome is a sub-compartment of the membranome and includes a complete set of ion channels and porins expressed in these cells. Many of these are multi-functional proteins with “moonlighting” roles, serving as channels, receptors and signalling components of larger molecular assemblies. The aim of this review is to summarise our current knowledge of the fundamental aspects of the chondrocyte channelome, discuss its relevance to cartilage biology and highlight its possible role in the pathogenesis of osteoarthritis (OA). Excessive and inappropriate mechanical loads, an inflammatory micro-environment, alternative splicing of channel components or accumulation of basic calcium phosphate crystals can result in an altered chondrocyte channelome impairing its function. Alterations in Ca2+ signalling may lead to defective synthesis of ECM macromolecules and aggravated catabolic responses in chondrocytes, which is an important and relatively unexplored aspect of the complex and poorly understood mechanism of OA development.  相似文献   
12.
13.
14.
In the current immunosuppressive therapy era, vessel thrombosis is the most common cause of early graft loss after renal transplantation. The prevalence of IgA anti–β2-glycoprotein I antibodies (IgA-aB2GPI-ab) in patients on dialysis is elevated (>30%), and these antibodies correlate with mortality and cardiovascular morbidity. To evaluate the effect of IgA-aB2GPI-ab in patients with transplants, we followed all patients transplanted from 2000 to 2002 in the Hospital 12 de Octubre prospectively for 10 years. Presence of IgA-aB2GPI-ab in pretransplant serum was examined retrospectively. Of 269 patients, 89 patients were positive for IgA-aB2GPI-ab (33%; group 1), and the remaining patients were negative (67%; group 2). Graft loss at 6 months post-transplant was significantly higher in group 1 (10 of 89 versus 3 of 180 patients in group 2; P=0.002). The most frequent cause of graft loss was thrombosis of the vessels, which was observed only in group 1 (8 of 10 versus 0 of 3 patients in group 2; P=0.04). Multivariate analysis showed that the presence of IgA-aB2GPI-ab was an independent risk factor for early graft loss (P=0.04) and delayed graft function (P=0.04). There were no significant differences regarding patient survival between the two groups. Graft survival was similar in both groups after 6 months. In conclusion, patients with pretransplant IgA-aB2GPI-ab have a high risk of early graft loss caused by thrombosis and a high risk of delayed graft function. Therefore, pretransplant IgA-aB2GPI-ab may have a detrimental effect on early clinical outcomes after renal transplantation.  相似文献   
15.
16.
17.
18.
Obesity Surgery - Laparoscopic sleeve gastrectomy (LSG) is increasingly playing a key role in obesity management. Such operations, however, carry complications sometimes including leaks. The...  相似文献   
19.
20.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号