Characteristics of presystolic flow in the superior vena cava: new thoughts on a forgotten sound.

Cross sectional, M mode, and Doppler echocardiography, apexcardiography, and phonocardiography were used to characterise presystolic cardiovascular sounds in three patients with ventricular disease. Although the aetiology was different (dilated cardiomyopathy, primary pulmonary hypertension, and chronic pulmonary thromboembolic disease), in each case the presystolic sound was associated with a rapid change in acceleration of blood and with flow reversal in the superior vena cava, and could only be recorded at the right sternal edge or over the jugular veins. Such flow characteristics may be explained by a raised ventricular end diastolic pressure with reduced compliance. Use of these techniques helps to understand the cause of a previously described but little recognised heart sound, and adds weight to the interpretation of its presence in disease.     

精氨酸加压素（AVP）的衍生物AVP4—8不能作用于AVPV1a受体而诱发电流反应

在微量注射大量肝脏ｍＲＮＡ之后，通过电压箝方法进行功能鉴定，两栖类卵母细胞成功地表达了ＡＶＰＶ１ａ受体。但在灌流ＡＶ４－８溶液时，却不能诱导卵母细胞产生内向振荡电流反应。提示ＡＶＰ４－８不能通过ＡＶＰＶ１ａ受体而介导生理学效应。     

延颈髓交界处髓内肿瘤的诊断与显微手术治疗

报道显微手术治疗10例延颈髓交界处髓内肿瘤(ITCJ),肿瘤全切除6例,次全切除4例,无手术死亡,70％病例术后好转。ITCJ可分为颈延型和延颈型两大类型。MRI是诊断本病的主要方法,并且具有指导手术的重要意义。结果也表明,显微手术方法和术后呼吸功能监护很有必要。     

Location of lectin UEA-I receptors in histological diagnosis of nasopharyngeal precancerous lesion.

Three kinds of lectins (UEA-I, ConA, PNA) were used to study normal, dysplastic, neoplastic nasopharyngeal epithelium by lectin affinitive histochemical method. UEA-I (ulex europeus agglutinin-I) displayed membrane distribution in normal squamous epithelium, but most of nasopharyngeal carcinoma cells were negative. Notably, severe dysplastic epithelium (precancerous lesion) exhibited a strong membranous and cytoplasmic affinity, which contrasted sharply with the normal epithelium and carcinoma cells. The statistically significant difference in the content and distribution of lectin UEA-I in these three groups suggest that UEA-I is a hopeful marker for diagnosing precancerous lesion of the nasopharynx. However, PNA and ConA are of less diagnostic value.

     

单侧鼻前庭切口经蝶切除垂体腺瘤

对１６例垂体腺瘤采用单侧鼻前庭切口经蝶切除，效果满意，既可减少手术创伤，又缩短了手术距离，且避免了美容缺陷，是一种设计巧妙，较为实用的手术方法，尤其适用于生长激素腺瘤。     

HCVRNA阳性的丙型肝炎诊断和治疗探讨

HCVRNA阳性的丙型肝炎46例，均经临床和／或组织学确诊。治疗组24例用IFNa－nl或a－2b3×106IU，隔日一次；对照组22例用一般护肝药物。HCVRNA12周转阴率治疗组为83．3％，对照组为9．0％（P＜0．001）。ALT和AST复常率治疗组也优于对照组（P＜0．05）。随访观察满48周者治疗组15例中HCVRNA持续转阴11例（73．3％）．对照组5例均持续阳性。治疗组中5例做了Ⅰ～Ⅲ型HCV基因分型，结果均为Ⅱ型。同时对急、慢性丙型肝炎的发病过程和病理诊断作了讨论。     

Determination of antigen-dependent activity of human lung cancer transfer factor by H3-leucine leucine leukocyte adherence inhibition assay]

This report is to demonstrate the antigen-dependent activity of human lung cancer transfer factor (Sp-TF). Sp-TFM was prepared from spleen of mice immunized with the human lung cancer cell line A549. [3H]-leu leukocyte adherence inhibition assay ([3H]-leu-LAI) was modified to identify activity of Sp-TFM. Leukocytes obtained from non-immunized mice were divided into eight groups as follows: 1. Control without TF or antigen; 2. Sp-TFM and antigen of cell line A549 (A549 Ag); 3. Sp-TFM alone; 4. Sp-TFM and ascitic tumor cell H22 antigen of mice (H22Ag); 5. Sp-TFM and antigen of human gastric cancer cell (HGCCAg); 6. Sp-TFM and antigen of human normal lung tissue (NLTAg); 7. Nor special TF of mice (N-TFM) and A549Ag; 8. A549Ag alone. When normal leukocytes were incubated with Sp-TFM and A549 antigen, the leukocytes adherence inhibition index (LAII) was significantly higher than those of the other groups. The different LAII of Sp-TFM to A549Ag and other experimental groups were highly significant (P less than 0.001). The results demonstrated that Sp-TFM could transfer specific cell mediated immunity to non-immune leukocytes. The TF prepared from spleen of goat immunized with antigen from lung cancer of patients (Sp-TFG) showed antigen specific activity as well as Sp-TFM.     

人脑胶质瘤逃避免疫监视机制的研究

为研究胶质瘤逃避免疫监视的机制，检测了胶质瘤体外细胞系培养上清（SN）抗PHA－P刺激正常人及胶质瘤患者外周血淋巴细胞增殖的作用。证实了胶质瘤可自分泌免疫抑制因子。经抗TGFβ2单抗中和SN试验，TGFβ2免疫组化染色及Northern杂交进一步表明该因子主要成分为TGFβ2并对胶质瘤患者血浆皮质醇，生长激素及儿茶酚胺含量及细胞免疫功能进行检测，发现血浆去甲肾上腺素显著降低，其水平与CD8亚群％呈负相关，与CD4／CD8比值及淋巴细胞增殖率呈正相关。初步提示存在胶质瘤的情况下，神经－免疫调控紊乱，可能起着抑制性调节作用。     

VEGF在肺癌组织中的表达及临床意义

目的：探讨血管内皮生长因子在肺癌中的表达情况与肺癌病理生物学行为之间的关系。方法：采用免疫组化SP法检测47例肺癌组织和10正常肺组织中VEGF的表达水平。结果：肺癌组织中VEGF的表达明显高于正常肺组织(P＜0．005)，P53、VEGF表达与肺癌的分化程度、淋巴结转移及P—TNM分期密切相关(P＜0．05)，与患者的性别、年龄、肿瘤大小及组织类型无关(P＞0．05)。结论：检测肺癌组织中VEGF的表达水平有助于了解肿瘤的生物学行为，并可作为判断其预后的有价值指标。