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191.
Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease. 总被引:9,自引:0,他引:9
Aurélie Funkiewiez Claire Ardouin Paul Krack Valérie Fraix Nadège Van Blercom Jing Xie Elena Moro Alim-Louis Benabid Pierre Pollak 《Movement disorders》2003,18(5):524-530
High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves the motor symptoms of Parkinson's disease (PD). Opposite changes in mood, such as mania or depression, have been reported after surgery, but it is not known whether these side effects are specifically related to STN DBS. To learn whether STN DBS also influences the limbic loop, we investigated acute subjective psychotropic effects related to levodopa or bilateral STN DBS. After a median postoperative follow-up of 12 months, 50 PD patients completed the Addiction Research Center Inventory (ARCI), assessing subjective psychotropic effects in four conditions: off-drug/on-stimulation; off-drug/off-stimulation; on-drug/off-stimulation; and on-drug/on-stimulation. Both levodopa and STN DBS improved all the ARCI subscales, indicating subjective feelings of well being, euphoria, increase in motivation, and decrease in fatigue, anxiety, and tension. A suprathreshold dose of levodopa was significantly more effective than STN DBS, using the same electrical parameters as for chronic stimulation, on four of the five ARCI subscales. We concluded that 1) both STN DBS and levodopa have synergistic acute beneficial psychotropic effects in PD, 2) the psychotropic effects of both treatments need to be considered in the long-term management of chronic STN DBS, and 3) the results indicate an involvement of the limbic STN in mood disorders of PD. 相似文献
192.
Dao Yin Xie Stefan Hassenstein Martin Oberhoff Hartmut Hanke Andreas Baumbach Kristian Hohla Karl Konstantin Haase Karl Rüdiger Karsch 《Lasers in surgery and medicine》1993,13(6):618-624
A modified exeimer laser energy delivery system was used to irradiate 100 segments of normal and fibrous aorta in vitro. The laser beam was scanned into 8 fiber bundles consisting of 50 fibers each resulting in a reduction of the applied pulse energy. The total repetition rate was increased to 150 Hz in order to keep the repetition rate per fiber bundle close to 20 Hz and to minimize thermal injury. The results demonstrate that effective ablation (etch rate per 8 pulses > 2.0 μm) occurred at an energy fluency of 50 mJ/mm2 in both normal and fibrous aorta. Tissue damage (carbonization, tissue separation, fissures, cracks, and vacuolization) was in a range of 100 ± 28 to 152 ± 30 μm for normal aorta and in a range of 57 ± 35 to 110 ± 39 μm for fibrous aorta. We conclude that effective ablation of normal and fibrous human aorta can be achieved by the application of smooth excimer laser coronary angioplasty. This improvement of excimer laser technology may result in a reduction of shock wave- and cavitation-induced damage leading to a reduction of tissue injury. However, this awaits further in vitro and in vivo confirmation. © 1993 Wiley-Liss, Inc. 相似文献
193.
Radiologic and pathologic mani;estations of 30
peripheral pulmonary masses around l.5-3 cm in dia-
meter were compared to the pathologic basis of va-
cuole sign and small node sign on tomogram. Stati
stics of 100 conventional X-ray tomograms of peri-
pheral pulmonary masses about l-3 cm in diameter
suggested that the vacuole sign and small node sign,
more common in early peripheral lung cancer than
in tuberculoma, are valuable for differentiating early
peripheral lung cancer from tuberculoma. 相似文献
194.
随着螺旋CT成像技术的不断发展,螺旋CT扫描对腹部及腹膜后等疾病的显示,特别是对肝脏等实质部分的显示,是传统X线摄影所不及的。肝脏螺旋CT检查技术已经日益成为肝癌等肝脏占位性病变的常规检查方法,如何提高螺旋CT扫描的图像质量以满足临床诊断是需要进一步解决的问题。笔者通过实践,对如何合理地优化扫描参数,得到高质量的图像有一些经验体会,现总结如下。 相似文献
195.
All mammalian metallothionaln genes studied to dare have several metal responsive elements (MRE) with consensus sequences of TGCRCNC (R, purlne) in their regulatory region. MRE-11ke sequeaees were also found in many other metal-related genes. To see whether there is also such a sequence at the genetic locus (13q14. 3) d Wilstm disease, which is a genetic disorder d copper metabolisa‘‘n, junction-trapping method baaed on the MRE sequence was used. A fragment containing MRE and MRE-like sequences from YAC 27D8 at the WND locus was successfully cloned and mapped back to the YAC by PC, R, Presence of such a sequence in the copper transporter gene at the W‘‘D locus might imply that it has a possible interesting role in the regulation of WD gene expression. 相似文献
196.
目的进一步研究声带小结与息肉的治疗手段。方法采用日本OlimpusBFp20型纤支镜和国产FF-99光电子内窥镜显示仪,配合间接万向喉钳治疗声带小结和息肉57例。结果治愈率92%,病人痛苦小。结论纤支镜配合间接喉钳手术治疗声带小结和息肉效果良好。 相似文献
197.
本文观察了频率为20Hz、振幅为0.67mm和作用时间为40min的振动预处理对急性缺氧小鼠肺损伤的影响。结果发现实验组的肺组织匀浆脂质过氧化物LghdPeroxde(LPO)、支气管肺泡灌洗液(BALF)中蛋白含量和白细胞数明显低于对照组(P<0.05)。这表明在特定率数的振动作用下能明显减轻急性缺氧小鼠肺的损伤。 相似文献
198.
对10名男性受试者单剂量po240mgVer缓释片药代动力学及心电图变化进行研究。血药浓度—时间数据用零级吸收过程的一室模型拟合,其药代动力学参数:Tmax5.9±1.6h;Cmax118.9±37.2μg·L-1;T1 5.4±1.5h;k030.5±17.5μg·L-1·h-1;T1/210.8±4.9h。PR间期延长有显著意义,血药浓度与PR间期变化满足S 型模型,其药效学参数:EC50 64.6±16.9μg·L-1; Emax54±11ms;s 1.68±0.66。 相似文献
199.
用Multiquadric方法实现医学图像的弹性配准 总被引:3,自引:1,他引:2
目的改进医学图像弹性配准的精确度和配准方法的稳定性,并简化配准操作。方法 利用Multiquadric插值方法的可平滑性质,将其与一种半自动标记点选择方法结合。建立一种新配准方法。结果 运用此方法进行医学图像的弹性配准,实现了标准图像与变形图像的快速,准确配准,结论 我们建立的配准方法是一种准确。简便和稳定的方法。 相似文献
200.
Stéphane Thobois Jing Xie Helena Mollion Isabelle Benatru Emmanuel Broussolle 《Movement disorders》2004,19(8):965-966
We describe the first case of orofacial abnormal movements induced by adrafinil, a vigilance promoting agent of the same pharmacological class as modafinil. The dyskinesias did not spontaneously recover despite adrafinil withdrawal for a 4-month period. They were secondly dramatically improved by tetrabenazine, a presynaptic dopaminergic depleting drug which was introduced after the 4-month adrafinil-free period. 相似文献