Recurrent high fever with macular papules in an elderly male: a case report

Immunologic Research -     

Long Non-coding RNA FENDRR Modulates Autophagy Through Epigenetic Suppression of ATG7 via Binding PRC2 in Acute Pancreatitis

Inflammation - Acute pancreatitis (AP) is an inflammatory, complicated pancreatic disease, carrying significant morbidity and mortality. However, the molecular and cellular mechanisms involved in...     

Paclitaxel-induced stress granules increase LINE-1 mRNA stability to promote drug resistance in breast cancer cells

Abnormal expression of long interspersed element-1 (LINE-1) has been implicated in drug resistance, while our previous study showed that chemotherapy drug paclitaxel (PTX) increased LINE-1 level with unknown mechanism. Bioinformatics analysis suggested the regulation of LINE-1 mRNA by drug-induced stress granules (SGs). This study aimed to explore whether and how SGs are involved in drug-induced LINE-1 increase and thereby promotes drug resistance of triple negative breast cancer (TNBC) cells. We demonstrated that SGs increased LINE-1 expression by recruiting and stabilizing LINE-1 mRNA under drug stress, thereby adapting TNBC cells to chemotherapy drugs. Moreover, LINE-1 inhibitor efavirenz (EFV) could inhibit drug-induced SG to destabilize LINE-1. Our study provides the first evidence of the regulation of LINE-1 by SGs that could be an important survival mechanism for cancer cells exposed to chemotherapy drugs. The findings provide a useful clue for developing new chemotherapeutic strategies against TNBCs.     

Profiling the differences of gut microbial structure between schizophrenia patients with and without violent behaviors based on 16S rRNA gene sequencing

International Journal of Legal Medicine - Understanding the violence behaviors in schizophrenia patients has always been the focus of forensic psychiatry. Although many studies show gut microbiota...     

PP2A-C may be a promising candidate for postmortem interval estimation

International Journal of Legal Medicine - Determining the postmortem interval (PMI) is an important task in forensic pathology. However, a reliable means of determining the PMI between...     

The forensic landscape and the population genetic analyses of Hainan Li based on massively parallel sequencing DNA profiling

International Journal of Legal Medicine - Due to the formation of the Qiongzhou Strait by climate change and marine transition, Hainan island was isolated from the mainland southern China during...     

5-羟色胺转运体基因多态性与抑郁的关系研究进展

抑郁症作为一种复杂的情感性精神障碍,其病因及病理机制至今尚未完全阐明。5-羟色胺(5-HT)系统可能在抑郁的起病及发展中起重要作用,许多研究者在探索5-羟色胺转运体基因启动子区域连锁多态性(5-HTTLPR)与抑郁的关系上作了大量工作,已有许多研究成果出现,本文对以往的相关研究做一个综述。