全文获取类型
收费全文 | 2500361篇 |
免费 | 175649篇 |
国内免费 | 3323篇 |
专业分类
耳鼻咽喉 | 33032篇 |
儿科学 | 81873篇 |
妇产科学 | 65393篇 |
基础医学 | 362596篇 |
口腔科学 | 65055篇 |
临床医学 | 221965篇 |
内科学 | 484188篇 |
皮肤病学 | 52305篇 |
神经病学 | 199527篇 |
特种医学 | 96028篇 |
外国民族医学 | 489篇 |
外科学 | 379222篇 |
综合类 | 49727篇 |
现状与发展 | 12篇 |
一般理论 | 849篇 |
预防医学 | 198105篇 |
眼科学 | 56837篇 |
药学 | 183530篇 |
11篇 | |
中国医学 | 5198篇 |
肿瘤学 | 143391篇 |
出版年
2021年 | 19033篇 |
2019年 | 19576篇 |
2018年 | 46264篇 |
2017年 | 35574篇 |
2016年 | 39792篇 |
2015年 | 26472篇 |
2014年 | 36805篇 |
2013年 | 54611篇 |
2012年 | 80837篇 |
2011年 | 97876篇 |
2010年 | 63313篇 |
2009年 | 54741篇 |
2008年 | 91587篇 |
2007年 | 98503篇 |
2006年 | 80768篇 |
2005年 | 79636篇 |
2004年 | 77453篇 |
2003年 | 75599篇 |
2002年 | 71617篇 |
2001年 | 108964篇 |
2000年 | 111803篇 |
1999年 | 93626篇 |
1998年 | 27162篇 |
1997年 | 23846篇 |
1996年 | 24109篇 |
1995年 | 22806篇 |
1994年 | 20972篇 |
1993年 | 19761篇 |
1992年 | 72022篇 |
1991年 | 70143篇 |
1990年 | 68501篇 |
1989年 | 65721篇 |
1988年 | 60344篇 |
1987年 | 59152篇 |
1986年 | 55238篇 |
1985年 | 53027篇 |
1984年 | 39327篇 |
1983年 | 33417篇 |
1982年 | 19881篇 |
1979年 | 35869篇 |
1978年 | 25659篇 |
1977年 | 21233篇 |
1976年 | 20340篇 |
1975年 | 21821篇 |
1974年 | 26165篇 |
1973年 | 24803篇 |
1972年 | 23200篇 |
1971年 | 22037篇 |
1970年 | 20262篇 |
1969年 | 19331篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
A. Schettino C. Giordano A. Parisi G. Calabrò 《Journal of the European Academy of Dermatology and Venereology》1995,4(2):153-154
We describe a mild form of drug-induced pemphigus in a woman with essential arterial hypertension treated with captopril. Complete recovery was observed three weeks after the therapy had been discontinued. 相似文献
992.
New latex reagent using monoclonal antibodies to capsular polysaccharide for reliable identification of both oxacillin-susceptible and oxacillin-resistant Staphylococcus aureus. 总被引:5,自引:5,他引:0
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
J M Fournier A Bouvet D Mathieu F Nato A Boutonnier R Gerbal P Brunengo C Saulnier N Sagot B Slizewicz et al. 《Journal of clinical microbiology》1993,31(5):1342-1344
A new latex agglutination test (Pastorex Staph-Plus, Sanofi Diagnostics Pasteur), consisting of a mixture of latex particles coated with fibrinogen and immunoglobulin G for the detection of clumping factor and protein A and latex particles sensitized with monoclonal antibodies directed to Staphylococcus aureus serotype 5 and 8 capsular polysaccharides, was compared with three commercially available rapid agglutination methods for the identification of 220 isolates of S. aureus (61 oxacillin resistant) and 128 isolates of coagulase-negative staphylococci. The sensitivity for identification of S. aureus was high with the Pastorex Staph-Plus test (98.6%) compared with those of the other tests, which ranged from 91.8 to 84.5%. Test sensitivities for the identification of oxacillin-resistant S. aureus were as follows: Pastorex Staph-Plus, 95.1%; Pastorex Staph, 73.8%; Staphyslide, 72.1%; and StaphAurex, 49.2%. 相似文献
993.
P. A. Milligan P. E. McGill C. W. Howden A. W. Kelman B. Whiting 《European journal of clinical pharmacology》1993,45(6):507-512
Summary A randomised crossover study was performed in subjects with rheumatoid arthritis (or other arthropathies) to investigate if any alteration in the steady pharmacokinetics of the NSAID piroxicam (a drug which is extensively metabolised via cytochrome P450) or its major metabolites occurred as a result of coadministering either cimetidine or nizatidine.Twelve females and 2 males with mean age, weight, and albumin concentrations of 58 years, 61 kg, and 40 g·L–1 respectively, completed the study. Comparisons were made between the following parameters: plasma piroxicam AUCs [AUC0-24(P)], plasma 5-hydroxypiroxicam AUCs [AUC0-24(5-OHP)], the ratio of these i.e. AUC0-24(5-OHP):AUC0-24(p), the % piroxicam daily dose excreted in urine as 5-hydroxypiroxicam (before and after glucuronidase incubation); and the mean of the steady state trough piroxicam, and 5-hydroxypiroxicam concentrations (obtained during each study phase in addition to the wash-out period).A statistically significant difference as a result of initiating either cimetidine or nizatidine was obtained only for the ratio AUC0-23(5-OHP):AUC0-24(P). This was indicative of a weak potential to inhibit piroxicam hydroxylation.No clinically significant alteration in the steady state pharmacokinetics of piroxicam occurred in these subjects as a result of cimetidine or nizatidine coadministration. Consequently it is unlikely that any adverse events would arise from these combinations. 相似文献
994.
995.
Sarah A. Taylor Jacqueline Benedetti David Schuller Stephen P. Richman Goronwy O. Broun Alexander Hantel 《Investigational new drugs》1993,11(2-3):227-229
Summary Twenty-two patients with recurrent or metastatic squamous cell carcinoma of the head and neck were treated with piroxantrone 150 mg/m2 intravenously every 21 days. There were no objective responses. The 95% upper confidence bound for response is 15%. Primary toxicity was hematologic. 相似文献
996.
997.
David A. Hughes Graham C. Smith Joyce E. Davidson Anna V. Murphy T. James Beattie 《Pediatric nephrology (Berlin, Germany)》1996,10(4):445-447
. Neutrophil-mediated tissue damage has been implicated in the pathogenesis of diarrhoea-associated haemolytic uraemic syndrome
(D+ HUS). This study evaluates priming and activation of the neutrophil oxidative burst in D+ HUS using chemiluminescent techniques.
Peripheral blood neutrophils from 11 children with acute D+ HUS were examined. No difference was found in the oxidative burst
of neutrophils from patients and controls. Serum elastase levels were measured in 8 patients and found to be significantly
elevated. Although elastase results suggest neutrophil activation, chemiluminescence studies do not confirm this in the peripheral
blood neutrophil. This does not support a significant role for circulating agents in priming and activating the peripheral
blood neutrophil.
Received August 17, 1995; received in revised form and accepted November 27, 1995 相似文献
998.
Dysregulated Fas and Bcl-2 expression leading to enhanced apoptosis in T cells of multiple myeloma patients 总被引:3,自引:1,他引:2
Massaia M; Borrione P; Attisano C; Barral P; Beggiato E; Montacchini L; Bianchi A; Boccadoro M; Pileri A 《Blood》1995,85(12):3679-3687
We have previously reported the presence of activated (HLA-DR+) T cells in multiple myeloma (MM) patients. These cells produce high amounts of interleukin (IL)-2 and interferon (IFN)-gamma and generate a potent antiplasma cell activity after appropriate in vitro stimulation, but they are unable in vivo to hold in check the disease. Activated T cells are highly susceptible to apoptosis, a form of programmed cell death involved in the modulation of immune responses and regulated by molecules such as Fas (CD95) and bcl-2. The aim of this study was to determine the expression of Fas and bcl-2 antigens and the susceptibility to apoptosis in T cells of MM patients. Fas+ cells were significantly higher, whereas bcl-2+ cells were significantly lower in MM patients than in the controls. MM patients with the highest number of HLA-DR+ T cells showed the highest Fas and the lowest bcl-2 expression. Two-color cytofluorometric analysis confirmed in individual cells that HLA-DR+ T cells coexpressed Fas and lacked bcl-2. Susceptibility to apoptosis was then investigated to evaluate the consequence of dysregulated Fas and bcl-2 expression. The percentage of apoptotic cells after incubation in medium alone (spontaneous apoptosis) or in the presence of methylprednisolone (MP) or anti-Fas monoclonal antibody (triggered apoptosis) was significantly higher in MM and mainly restricted to HLA-DR+ T cells. Spontaneous apoptotosis was reverted by exogenous IL-2. In conclusion, MM T cells have a dysregulated expression of Fas and bcl-2 antigens that is associated with an enhanced susceptibility to apoptosis. These data may unravel a novel mechanism by which activated MM T cells are weakened in their ability to exert an effective antitumor activity in vivo. 相似文献
999.
Excessive zinc ingestion. A reversible cause of sideroblastic anemia and bone marrow depression 总被引:2,自引:0,他引:2
Two patients with sideroblastic anemia secondary to zinc-induced copper deficiency absorbed excess zinc secondary to oral ingestion. The source of excess zinc was a zinc supplement in one case; in the other, ingested coins. In each case, the sideroblastic anemia was corrected promptly after removal of the source of excess zinc. These two cases emphasize the importance of recognizing this clinical entity, since the myelodysplastic features are completely reversible. 相似文献
1000.
The introduction of new diagnostic tools for neuroimaging has resulted in the early recognition of congenital brain tumors. In the present report we describe a personal series of 39 children and an International Multicenter Series of 876 children with brain tumors, in whom the diagnosis was obtained during the first 12 months of life. Most of the tumors were located within the supratentorial compartment. In spite of a relatively high operative mortality, surgery still appears to be the more effective therapy. Radiotherapy in this age group is of a scarce value, due to the vulnerability of the infantile brain. At the present time, chemotherapy still plays a controversial role. 相似文献