全文获取类型
收费全文 | 1479篇 |
免费 | 74篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 27篇 |
儿科学 | 65篇 |
妇产科学 | 20篇 |
基础医学 | 142篇 |
口腔科学 | 32篇 |
临床医学 | 133篇 |
内科学 | 377篇 |
皮肤病学 | 111篇 |
神经病学 | 93篇 |
特种医学 | 223篇 |
外科学 | 144篇 |
综合类 | 30篇 |
预防医学 | 91篇 |
眼科学 | 6篇 |
药学 | 40篇 |
中国医学 | 4篇 |
肿瘤学 | 48篇 |
出版年
2021年 | 8篇 |
2020年 | 8篇 |
2019年 | 13篇 |
2018年 | 14篇 |
2017年 | 14篇 |
2016年 | 20篇 |
2015年 | 24篇 |
2014年 | 30篇 |
2013年 | 72篇 |
2012年 | 19篇 |
2011年 | 19篇 |
2010年 | 56篇 |
2009年 | 67篇 |
2008年 | 27篇 |
2007年 | 35篇 |
2006年 | 41篇 |
2005年 | 41篇 |
2004年 | 30篇 |
2003年 | 21篇 |
2002年 | 35篇 |
2001年 | 33篇 |
2000年 | 17篇 |
1999年 | 25篇 |
1998年 | 84篇 |
1997年 | 73篇 |
1996年 | 76篇 |
1995年 | 50篇 |
1994年 | 63篇 |
1993年 | 53篇 |
1992年 | 16篇 |
1991年 | 19篇 |
1990年 | 24篇 |
1989年 | 43篇 |
1988年 | 44篇 |
1987年 | 34篇 |
1986年 | 26篇 |
1985年 | 26篇 |
1984年 | 23篇 |
1983年 | 14篇 |
1982年 | 23篇 |
1981年 | 18篇 |
1980年 | 14篇 |
1979年 | 19篇 |
1978年 | 15篇 |
1977年 | 16篇 |
1976年 | 17篇 |
1975年 | 13篇 |
1973年 | 16篇 |
1972年 | 9篇 |
1971年 | 8篇 |
排序方式: 共有1586条查询结果,搜索用时 15 毫秒
41.
AJL Jowett SWF Middleton MC Quaye H Chesterfield I Lasrado FM Witham 《Annals of the Royal College of Surgeons of England》2014,96(2):e13-e16
We present an unusual case of haematogenous osteomyelitis in the diaphysis of the tibia of an adult leading to a subacute presentation with an extracortical abscess. Fluid from the abscess grew methicillin resistant Staphylococcus aureus (MRSA) on culture; MRSA with the same antibiogram had been grown from the patient’s blood seven years earlier following a bowel resection. Drainage of the abscess and curettage of the bone lesion together with appropriate antibiotic therapy led to resolution of the osteomyelitis. 相似文献
42.
Isoelectric focusing on slabs of acrylamide gel was adapted for the screening of abnormal hemoglobins, the characterization of 70 human variants, and the study of minor fractions of normal hemoglobin. The screening method was as fast and inexpensive as conventional techniques, allowed the simultaneous analysis of some 50 samples of whole blood, and yielded resolution superior to that obtained by other methods with hemolysates. Among the 70 variants, 31 mutants could not be separated from HbS by cellulose acetate electrophoresis. The characterization technique of electrofocusing allowed us to distinguish between most variants. Only one mutant, Hb Galveston, could be confused with HbS. Hb Koln, the most frequent unstable mutant, exhibited a special pattern. HbA1C was separated from HbA. Preliminary results indicate that quantitation of HbA1C by gel scanning is feasible. 相似文献
43.
Dr. Daniel L. Anderson MD MAJ MC H. Worth Boyce Jr MD COL MC 《Digestive diseases and sciences》1973,18(8):633-640
Eight patients with advanced regional enteritis characterized by multiple areas of involvement, previous surgery (5 of 8), and failure on medical therapy (6 of 8) were placed on total parenteral nutrition for a period of 30 days. In eight of nine courses administered, definite improvement marked by weight gain, diminished pain, decreased diarrhea, and increased serum albumin was found. However, clinical remission was transient in seven of eight successful courses, indicating that parenteral nutrition is not a definitive form of therapy. However, the results suggest that parenteral nutrition may be useful in patients with regional enteritis to a) restore nutrition, b) induce remission, and c) prepare a debilitated patient for surgery. Additional experience is required to determine the efficacy of parenteral nutrition for therapy of fistulae caused by regional enteritis. 相似文献
44.
Gerald E. Smith MD LT COL MC Lynn R. Kime MAJ MC J. Loren Pitcher MD FACP COL MC 《Digestive diseases and sciences》1973,18(11):987-1000
Summary An additional case of Behcet's disease with colonic involvement has been presented. This association is rare, as only 13 prior cases with adequate data were available for comparison. Controversy exists as to whether these cases represented true involvement of the colon by Behcet's disease, coincidental inflammatory bowel disease and Behcet's disease, or merely autoimmune phenomena associated with inflammatory bowel disease. Unusual colonoscopic lesions noted in our patient and other features enumerated in the text suggested to us that at least some of these cases represented primary Behcet's disease involving the colon. 相似文献
45.
46.
Summary In summary, the vascular bed of the stomach is an area of great potential importance to both gastric and vascular physiologists. There are available many technics for its investigation. Simultaneous study of both hemodynamic and secretory phenomena can be conducted on the stomach. In the next few years information concerning the circulation of the stomach may help elucidate problems in the physiology and pathology of gastric secretion. Hightower observed recently: The topic of visceral circulation, particularly as it pertains to the digestive tract, has not been commented upon in recent...Reviews of Physiology. This subject has become increasingly important in the past few years and is an area with which physiologists interested in the digestive system will become more and more concerned.33 相似文献
47.
48.
49.
Widespread Differential Maternal and Paternal Genome Effects on Fetal Bone Phenotype at Mid‐Gestation 下载免费PDF全文
Ruidong Xiang Alice MC Lee Tanja Eindorf Ali Javadmanesh Mani Ghanipoor‐Samami Madeleine Gugger Carolyn J Fitzsimmons Zbigniew A Kruk Wayne S Pitchford Alison J Leviton Dana A Thomsen Ian Beckman Gail I Anderson Brian M Burns David L Rutley Cory J Xian Stefan Hiendleder 《Journal of bone and mineral research》2014,29(11):2392-2404
Parent‐of‐origin–dependent (epi)genetic factors are important determinants of prenatal development that program adult phenotype. However, data on magnitude and specificity of maternal and paternal genome effects on fetal bone are lacking. We used an outbred bovine model to dissect and quantify effects of parental genomes, fetal sex, and nongenetic maternal effects on the fetal skeleton and analyzed phenotypic and molecular relationships between fetal muscle and bone. Analysis of 51 bone morphometric and weight parameters from 72 fetuses recovered at day 153 gestation (54% term) identified six principal components (PC1–6) that explained 80% of the variation in skeletal parameters. Parental genomes accounted for most of the variation in bone wet weight (PC1, 72.1%), limb ossification (PC2, 99.8%), flat bone size (PC4, 99.7%), and axial skeletal growth (PC5, 96.9%). Limb length showed lesser effects of parental genomes (PC3, 40.8%) and a significant nongenetic maternal effect (gestational weight gain, 29%). Fetal sex affected bone wet weight (PC1, p < 0.0001) and limb length (PC3, p < 0.05). Partitioning of variation explained by parental genomes revealed strong maternal genome effects on bone wet weight (74.1%, p < 0.0001) and axial skeletal growth (93.5%, p < 0.001), whereas paternal genome controlled limb ossification (95.1%, p < 0.0001). Histomorphometric data revealed strong maternal genome effects on growth plate height (98.6%, p < 0.0001) and trabecular thickness (85.5%, p < 0.0001) in distal femur. Parental genome effects on fetal bone were mirrored by maternal genome effects on fetal serum 25‐hydroxyvitamin D (96.9%, p < 0.001) and paternal genome effects on alkaline phosphatase (90.0%, p < 0.001) and their correlations with maternally controlled bone wet weight and paternally controlled limb ossification, respectively. Bone wet weight and flat bone size correlated positively with muscle weight (r = 0.84 and 0.77, p < 0.0001) and negatively with muscle H19 expression (r = –0.34 and –0.31, p < 0.01). Because imprinted maternally expressed H19 regulates growth factors by miRNA interference, this suggests muscle‐bone interaction via epigenetic factors. © 2014 American Society for Bone and Mineral Research. 相似文献
50.
Hilary A. Seifert Lisa A. Collier Cortney B. Chapman Stanley A. Benkovic Alison E. Willing Keith R. Pennypacker 《Journal of neuroimmune pharmacology》2014,9(5):679-689
The delayed immune response to stroke is responsible for the increased neural injury that continues to occur after the initial ischemic event. This delayed immune response has been linked to the spleen, as splenectomy prior to middle cerebral artery occlusion (MCAO) is neuroprotective. Interferon gamma (IFNγ) is linked to the splenic response, which enhances neural injury following MCAO. IFNγ activates the expression of the inflammatory chemokine interferon-inducible protein 10 (IP-10). This study was designed to determine the role of IFNγ signaling in the inflammatory response following MCAO. Expression of IP-10 increased in the brain and the spleen following MCAO. Splenectomy inhibited the increase of IP-10 in the brain post-MCAO, while recombinant IFNγ administration to splenectomized rats returned IP-10 levels in the brain to levels found in rats after MCAO only. Systemic administration of an IFNγ neutralizing antibody to MCAO-treated rats reduced infarct volume and IP-10 levels in the brain. T cell infiltration was reduced in the MCAO-damaged brains of IFNγ antibody-treated animals relative to those that received isotype control antibodies. Additionally, inhibiting IFNγ signaling with splenectomy or an IFNγ neutralizing antibody blocked the induction of IP-10 expression and decreased neurodegeneration following MCAO. Targeting this pro-inflammatory pathway following stroke could be a promising stroke therapeutic. 相似文献