全文获取类型
收费全文 | 271671篇 |
免费 | 7838篇 |
国内免费 | 322篇 |
专业分类
耳鼻咽喉 | 2380篇 |
儿科学 | 9085篇 |
妇产科学 | 5271篇 |
基础医学 | 28572篇 |
口腔科学 | 3582篇 |
临床医学 | 21828篇 |
内科学 | 51769篇 |
皮肤病学 | 1708篇 |
神经病学 | 24765篇 |
特种医学 | 12135篇 |
外国民族医学 | 3篇 |
外科学 | 44468篇 |
综合类 | 3702篇 |
现状与发展 | 1篇 |
一般理论 | 75篇 |
预防医学 | 25628篇 |
眼科学 | 5353篇 |
药学 | 15565篇 |
中国医学 | 764篇 |
肿瘤学 | 23177篇 |
出版年
2023年 | 401篇 |
2022年 | 693篇 |
2021年 | 1647篇 |
2020年 | 882篇 |
2019年 | 1595篇 |
2018年 | 23557篇 |
2017年 | 18563篇 |
2016年 | 20799篇 |
2015年 | 2699篇 |
2014年 | 3479篇 |
2013年 | 5028篇 |
2012年 | 12963篇 |
2011年 | 27099篇 |
2010年 | 22104篇 |
2009年 | 14663篇 |
2008年 | 25287篇 |
2007年 | 28090篇 |
2006年 | 6956篇 |
2005年 | 8687篇 |
2004年 | 9735篇 |
2003年 | 10311篇 |
2002年 | 8484篇 |
2001年 | 1030篇 |
2000年 | 931篇 |
1999年 | 910篇 |
1998年 | 1469篇 |
1997年 | 1323篇 |
1996年 | 1041篇 |
1995年 | 1059篇 |
1994年 | 933篇 |
1993年 | 793篇 |
1992年 | 596篇 |
1991年 | 590篇 |
1990年 | 559篇 |
1989年 | 534篇 |
1988年 | 482篇 |
1987年 | 486篇 |
1986年 | 464篇 |
1985年 | 523篇 |
1984年 | 724篇 |
1983年 | 771篇 |
1982年 | 1001篇 |
1981年 | 915篇 |
1980年 | 905篇 |
1979年 | 449篇 |
1978年 | 537篇 |
1977年 | 582篇 |
1976年 | 498篇 |
1975年 | 433篇 |
1974年 | 358篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
81.
Isolated pure dislocations of the fifth carpo-metacarpal joint are extremely rare injuries. The dorsal form was described
in mere 12 cases. The diagnosis can be easily missed. The lesion is also often overlooked in the routine diagnostic X-ray.
Lateral and oblique views are important for the recognition of the true extent of the lesion. Treatment of these injures is
still controversial and both closed reduction with percutaneous pinning or open reduction with internal fixation are advocated.
The goal of treatment is early reduction and fixation of the metacarpal. Early diagnosis is the key to success. The aim of
this paper is to review literature and present two new cases. 相似文献
82.
R. I. Mustafin A. A. Protasova G. Van den Mooter V. A. Kemenova 《Pharmaceutical Chemistry Journal》2005,39(12):663-666
With a view to the development of new controlled drug delivery systems, the formation of an interpolyelectrolyte complex (IPEC)
between chitosan (CTS) and Eudragit L100 (L-100) has been studied. The structure of this IPEC is such that two maxima are
observed in the curves of IPEC swelling in the media with different pH values. The release of a model drug (ibuprofen) from
IPEC-based tablets is significantly retarded, and this delay can be controlled by changing the molecular weight of CTS in
the IPEC composition.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 12, pp. 44–46, December, 2005. 相似文献
83.
84.
Intractable tinnitus can lead to serious consequences. Study evidence indicates that the central nervous system is involved in generation and maintenance of chronic tinnitus and that tinnitus and other neurologic symptoms such as chronic pain may share similar mechanisms. Brain ablation and stimulation are used to treat chronic pain with success. Recent studies showed that ablation and stimulation in non-auditory areas resulted in tinnitus improvement. Deep brain stimulation (DBS) may be an alternative treatment for intractable tinnitus and deserves further study. 相似文献
85.
Beyond C4d: Other Complement-Related Diagnostic Approaches to Antibody-Mediated Rejection 总被引:3,自引:0,他引:3
William M. Baldwin III Edward K. Kasper rea A. Zachary Barbara A. Wasowska E. Rene Rodriguez 《American journal of transplantation》2004,4(3):311-318
Complement is a multifunctional system of receptors and regulators as well as effector molecules. Both the pathogenic and diagnostic power of complement is based on the capacity of the complement system to amplify innate and adaptive immunity. This amplification is accomplished through two strategies: (1) enzymatic reactions in the complement cascade, and (2) stimulation of leukocytes, platelets and parenchymal cells through specific receptors or receptor-independent pore formation. The mechanisms by which complement mediates and modifies nonspecific inflammation, antibody-mediated injury and T-cell responses are of particular significance to the pathogenesis of transplant rejection. Understanding the mechanisms by which complement integrates the interactions of leukocytes, platelets and parenchymal cells offers opportunities to further refine the diagnosis of rejection. 相似文献
86.
Yukinori Sakao Toru Sakuragi Yuji Takeda Masafumi Natsuaki Tsuyoshi Itoh 《General thoracic and cardiovascular surgery》2003,51(10):537-540
We experienced a rare case of giant cell tumor (GCT) arising in the 5th rib involving the 5th vertebral body and transverse process. A 57-year-old man presented with a well-defined mass in the left thoracic cavity on chest x ray examination. Chest computed tomography showed a heterogeneous 7cm-diameter mass originating in the posterior segment of the left 5th rib. The tumor had spread to the 5th thoracic vertebra destroying the left half of the body and transverse process. Magnetic resonance imaging showed a heterogeneous-intensity mass involving the 4th to 6th ribs. A radical excision of the tumor followed by a 50 Gy radiotherapy was performed after embolization of the feeding arteries. The pathological diagnosis was a GCT. The patient remains well without evidence of recurrence for 6 years following surgery. The present case is only the 14th case of GCT arising in the rib to have been reported in Japan. 相似文献
87.
Healthcare information systems (HISs) are often implemented to enhance the quality of care and the degree to which it is patient-centered,
as well as to improve the efficiency and safety of services. However, the outcomes of HIS implementations have not met expectations.
We set out to organize the knowledge gained in qualitative studies performed in association with HIS implementations and to
use this knowledge to outline an updated structure for implementation planning. A multi-disciplinary team performed the analyses
in order to cover as many aspects of the primary studies as possible. We found that merely implementing an HIS will not automatically
increase organizational efficiency. Strategic, tactical, and operational actions have to be taken into consideration, including
management involvement, integration in healthcare workflow, establishing compatibility between software and hardware and,
most importantly, user involvement, education and training. The results should be interpreted as a high-order scheme, and
not a predictive theory. 相似文献
88.
Andrew F Shorr William L Jackson Brendan M Weiss Lisa K Moores 《Blood coagulation & fibrinolysis》2007,18(4):309-316
Multiple options exist for the prevention of deep vein thrombosis (DVT) in medical inpatients. We sought to determine the cost-effectiveness of low-molecular-weight heparin (LMWH) relative to unfractionated heparin (UFH) for DVT prevention in this setting. We conducted a cost-effectiveness analysis from the perspective of a third-party payer employing a decision model and literature-based estimates for inputs. In the base-case analysis, LMWH had little impact on the rate of DVT. Despite higher acquisition costs, however, LMWHs resulted in net savings. Routine use of LMWH saves approximately US$89 per patient. The lower rate of heparin-induced thrombocytopenia (HIT) with LMWH accounted for this differential. Univariate sensitivity analysis revealed the model was moderately sensitive to the odds ratio of HIT with LMWH and the cost of HIT. Multivariate sensitivity analysis confirmed the LMWH approach dominated financially. 'Worst-case' scenario modeling, where LMWH actually increased the risk for DVT, had little effect on the rate of HIT, and was substantially more costly than UFH, still demonstrated that LMWHs were economically superior. Monte-Carlo simulation indicated the 95% confidence interval around the estimate for savings with LMWH ranged from US$7 to US$373. We conclude that, despite their higher cost, LMWHs for thromboprophylaxis in medical patients result in savings. 相似文献
89.
Association of Hypoalbuminemia on the First Postoperative Day and Complications Following Esophagectomy 总被引:1,自引:0,他引:1
Aoife M. Ryan Aine Hearty Ruth S. Prichard Aileen Cunningham Suzanne P. Rowley John V. Reynolds 《Journal of gastrointestinal surgery》2007,11(10):1355-1360
Objective Changes in serum albumin may reflect systemic immunoinflammation and hypermetabolism in response to insults such as trauma
and sepsis. Esophagectomy is associated with a major metabolic stress, and the aim of this study was to determine if the absolute
albumin level on the first postoperative day was of value in predicting in-hospital complications.
Methods A retrospective study of 200 patients undergoing esophagectomy for malignant disease at St. James Hospital between 1999 and
2005 was performed. Patients who had pre and postoperative (days 1, 3, and 7) serum albumin levels measured were included
in the study. Patients were subdivided into three postoperative albumin categories <20 g/l, 20–25 g/l, >25 g/l. Logistic regression
analysis was performed to calculate the odds of morbidity and mortality according to the day 1 albumin level.
Results Patients with an albumin of less than 20 g/l on the first postoperative day were twice as likely to develop postoperative
complications than those with an albumin of greater than 20 g/l (54 vs 28% respectively, p < 0.011). Correspondingly, these patients also had a significantly higher rate of Adult Respiratory Distress Syndrome (22
vs 5%, p < 0.001), respiratory failure (27 vs 8%, p < 0.01) and in-hospital mortality (27 vs 6% (p < 0.001). On multivariate logistic regression analysis, day 1 albumin level was independently related to postoperative complications
(odds ratios, 0.89: 95%; confidence intervals, 0.83–0.96; p < 0.005). In addition, albumin <20 g/l on the first postoperative day was associated with the need for further surgery and
a return to ICU.
Conclusion Serum albumin concentration on the first postoperative day is a better predictor of surgical outcome than many other preoperative
risk factors. It is a low cost test that may be used as a prognostic tool to detect the risk of adverse surgical outcomes. 相似文献
90.