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排序方式: 共有434条查询结果,搜索用时 15 毫秒
21.
Matsumoto AM Tenover L McClung M Mobley D Geller J Sullivan M Grayhack J Wessells H Kadmon D Flanagan M Zhang GK Schmidt J Taylor AM Lee M Waldstreicher J;Pless Study Group 《The Journal of urology》2002,167(5):2105-2108
PURPOSE: We determine the effect of long-term suppression of dihydrotestosterone with finasteride, a specific type II 5alpha-reductase inhibitor, on bone mineral density. MATERIALS AND METHODS: As part of a large (3,040 cases) 4-year, double-blind, placebo controlled trial designed to assess the long-term effects of finasteride in men with benign prostatic hyperplasia, 157 men 46 to 76 years old who were randomized to receive either 5 mg. finasteride or placebo underwent dual energy x-ray absorptiometry of the lumbar spine at baseline and at years 2, 3 and 4. RESULTS: Of 117 patients who had a baseline measurement and at least 1 additional measurement during the study baseline mean plus or minus standard deviation bone mineral density values were 1.12 +/- 0.17 gm./cm.2 in the finasteride group (63) and 1.10 +/- 0.17 gm./cm.2 in the placebo group (54). After 4 years bone mineral density was not different between treatment groups (finasteride 1.14 +/- 0.17 gm./cm.2 and placebo 1.13 +/- 0.18 gm./cm.2). Similar results were obtained for the 33 finasteride and 25 placebo treated patients who completed the study with year 4 bone mineral density measurements. CONCLUSIONS: These data demonstrate that long-term inhibition of type II 5alpha-reductase with finasteride does not adversely affect bone mineral density. 相似文献
22.
Templeton AW; Johnson JA; Anderson WH; Cook LT; Dwyer SJ d; Preston DF; Lee KR; Rosenthal SJ; Batnitzky S; Levine E 《Radiology》1984,151(2):527-528
The increasing use of digitally formatted imaging systems requires high-quality interactive gray-scale computer raster graphics systems for the management, display, and analog film recording of digital image and alphanumeric information. These systems are a combination of computer hardware and software and implement a set of graphics protocols. This paper describes a set of interactive graphics protocols that has been developed for clinical use. 相似文献
23.
Parathyroid adenomas evaluated by Tl-201/Tc-99m pertechnetate subtraction scintigraphy and high-resolution ultrasonography 总被引:2,自引:0,他引:2
Winzelberg GG; Hydovitz JD; O'Hara KR; Anderson KM; Turbiner E; Danowski TS; Lippe RD; Melada GA; Harrison AM 《Radiology》1985,155(1):231-235
Thallium-201/technetium-99m pertechnetate subtraction scintigraphy of the parathyroid glands was performed in a prospective study of 33 patients who had undergone bilateral neck exploration for elevated serum calcium and serum parathyroid hormone levels. In 31 cases, the Tl-201/Tc-99m subtraction technique yielded an overall sensitivity of 81%, specificity of 99%, and accuracy of 94% for identifying solitary parathyroid adenomas. Tl-201/Tc-99m subtraction scintigraphy correctly identified 73% of parathyroid adenomas weighing less than 499 mg, 79% of those weighing 500-1,499 mg, and 100% of adenomas weighing more than 1,500 mg. In a subgroup of 24 patients with solitary parathyroid adenomas who underwent both scintigraphy and high-resolution sonography, the sensitivity, specificity, and accuracy of both procedures were similar. 相似文献
24.
25.
Renal injury and operative management in the United States: results of a population-based study 总被引:3,自引:0,他引:3
Wessells H Suh D Porter JR Rivara F MacKenzie EJ Jurkovich GJ Nathens AB 《The Journal of trauma》2003,54(3):423-430
BACKGROUND: To evaluate the extent to which nonoperative renal trauma management has been adopted, we determined the incidence of renal injury and the rate of operative management across the United States. METHODS: International Classification of Diseases, Ninth Revision diagnosis and procedure codes identified patients with renal injuries in an 18-state administrative database representing 62% of the U.S. population. RESULTS: Of 523,870 patients hospitalized for trauma in 1997 or 1998, 6,231 (1.2%) had renal injuries (4.89 per 100,000 population). Sixty-four percent of patients with injuries that were classified had contusions/hematomas, 26.3% had lacerations, 5.3% had parenchymal disruption, and 4% had vascular injuries. Eleven percent of renal trauma patients required surgical management of their kidney injuries, of whom 61%, or 7% of patients with renal injuries overall, underwent nephrectomy. Injury Severity Score, mechanism, and renal injury severity were independent predictors of nephrectomy. CONCLUSION: The nephrectomy rate in community and academic centers reflects renal and global injury severity. Prospective trials are indicated to determine whether, in the traumatized patient with severe kidney injury, renal preservation could lead to improved outcomes compared with nephrectomy. 相似文献
26.
Angelis M Augenstein JS Ciancio G Figueiro J Sfakianakis GN Miller J Burke GW Wessells H 《The Journal of trauma》2003,54(3):606-9; discussion 609
27.
28.
老年胃癌患者围手术期并发症及其处理 总被引:2,自引:0,他引:2
目的 研究老年胃癌患者的临床特点,总结老年胃癌患者的年龄、术前各种合并症等对术后并发症发生的影响.方法 总结自2005年1月至2007年1月接受手术的181例胃癌患者的临床资料,其中老年患者(年龄大于65岁者)65例,回顾性分析老年胃癌患者的年龄、术前各种合并症与术后并发症发生的关系.结果 老年胃癌组术前合并症总发生率为83%,非老年胃癌组为59%;老年胃癌组中有52%存在2种或2种以上合并症,发生率最高的合并症为高血压,达40%;老年胃癌患者的根治率为86%,非老年胃癌组的根治率为93%;老年胃癌组术后并发症的发生率为37%,术前合并高血压、糖尿病、肺部疾病、低蛋白血症、贫血者术后并发症发生率较高.结论 老年胃癌患者手术治疗后的总并发症发生率和病死率与非老年胃癌患者相比无差异. 相似文献
29.
Nicole Piazza Michael Hayes Ian Martin Atanu Duttaroy Mike Grotewiel Robert Wessells 《Biogerontology》2009,10(5):637-648
Oxidative damage has been proposed as an important factor in the progression of pathological and non-pathological age-related
functional declines. Here, we examine functional deterioration in short-lived flies mutant for the mitochondrial antioxidant
Manganese Superoxide Dismutase (Sod2). We find that the decline of several functional measures of aging occurs, in an accelerated fashion, in Sod2 mutants. Olfactory behavior, locomotor ability and cardiac performance were all seen to decline rapidly in Sod2 mutants. On average, functional declines in Sod2 mutants occur in a pattern similar to that seen in late-life Drosophila with a normal complement of Sod2. In longitudinal experiments, however, we find that functional failures occur in every possible sequence in Sod2 mutants. Significantly, failure of these functional measures is not irreversible, as spontaneous functional recovery was
sometimes observed. These findings support a model where ROS-related damage strikes at multiple organ systems in parallel,
rather than a “chain of dominos” model, in which primary organ failure contributes to the deterioration of further organ systems.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
30.
Hunter Wessells 《World journal of urology》1999,17(2):107-114
Genital skin loss results from a heterogeneous group of traumatic and infectious processes. Removal of all devitalized tissue
is necessary prior to reconstructive surgery; hyperbaric oxygen may help in the management of necrotizing infections. Defect
coverage depends more on the remaining genital skin than on the etiology of the loss. 相似文献