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111.
淋巴结血管内T细胞淋巴瘤1例报道及文献复习 总被引:1,自引:0,他引:1
目的 探讨血管内淋巴瘤 (IVL)的临床病理特征。方法 对 1例腹股沟淋巴结IVL临床、病理组织学及免疫表型进行观察分析并复习文献。结果 男性 31岁 ,不明原因高热伴消瘦 5 0天 ,右腹股沟直径 1cm淋巴结 1枚 ,B超示肝脏轻度增大 ,血LDH明显升高伴ESR及转氨酶轻度升高 ,外周血WBC 3 3× 10 7/L ,骨髓像、多种病原及各肿瘤相关抗原检测均无异常。病理活检 :腹股沟淋巴结大部分破坏 ,代之以大量扩张的中小血管 ,腔内充满大量异型淋巴样细胞 ,局部伴管壁、管周浸润并累及结外脂肪组织。瘤细胞免疫表型CD4 5、CD4 5RO、CD3阳性 ,CK、CD6 8、CD79α、CD2 0均阴性 ,血管壁及内皮细胞CD31、CD34阳性。行CHOP化疗后症状缓解 ,现仍在随访中。结论 IVL是一罕见的非霍奇金淋巴瘤 ,好发于中枢神经系统及皮肤 ,其他部位少见 ,绝大数为B细胞型 ,T型罕见 ,以浅表淋巴结活检确诊者尚无报道。临床表现有一定提示性 ,确诊靠组织病理学检查 ,部分病例对化疗敏感 ,但多数病例预后差 相似文献
112.
Functional magnetic resonance imaging evidence for binocular interactions in human visual cortex 总被引:3,自引:0,他引:3
Büchert M Greenlee MW Rutschmann RM Kraemer FM Luo F Hennig J 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2002,145(3):334-339
Using functional magnetic resonance imaging (fMRI), we explored the binocular interactions occurring when subjects viewed dichoptically presented checkerboard stimuli. A flickering radial checkerboard was presented to each eye of the subject, while T2*-weighted images were acquired over the visual cortex with gradient-echo, echoplanar sequences. We compared responses in striate and extrastriate visual cortex under four conditions: both eyes were stimulated at the same time (binocular condition), each eye was stimulated in alternation (monocular condition) or first the one eye then the other eye was stimulated (left eye first - right eye trailing, or vice versa). The results indicate that only the striate area, in and near the calcarine fissure, shows significant differences for these stimulation conditions. These differences are not evident in more remote extrastriate or associational visual areas, although the BOLD response in the stimulation-rest comparison was robust. These results suggest that the effect could be related to inhibitory interactions across ocular dominance columns in striate visual cortex. 相似文献
113.
Yongxing Qiu Xiaojie Yu Linxian Feng Shilin Yang 《Macromolecular chemistry and physics.》1992,193(6):1377-1385
Using the rigid and hydrophobic polystyrene (PS) chain as backbone, onto which flexible and hydrophilic stearyl-poly(ethylene oxide) (SPEO) chains are grafted, a new kind of amphiphilic, microphase-separated graft copolymer was synthesized using the macromonomer technique. Stearyl-poly(ethylene oxide) macromonomers with acryloyl end-group (SPEO-A) were prepared through an end-group exchange reaction of α-stearyl-ω-hydroxypoly(ethylene oxide) (SPEO-OH) and acryloyl chloride in the presence of triethylamine. The radical copolymerization of styrene with SPEO-A was carried out under various experimental conditions. Following a careful examination of their purity, the structure of the prepared copolymers was characterized by means of IR, 1H NMR and GPC analyses. A new feasible method using first derivative UV spectrometry was developed for quantitative determination of the bulk composition of the graft copolymers. Copolymers with a wide range of bulk composition and satisfactory grafting degree were obtained. 相似文献
114.
115.
116.
女贞子、刺五加对T细胞促进作用的实验研究 总被引:11,自引:0,他引:11
女贞子和刺五加都是扶正中药.女贞子在体内体外对 T 细胞均有促进作用,但对其作用机理报导很少。刺五加是典型的“适应原样”药物,对机体免疫功能亦有促进作用,但其对 T 细胞的作用尚未见报导. 相似文献
117.
118.
Long-term survival after autologous bone marrow transplantation for follicular lymphoma in first remission. 总被引:1,自引:0,他引:1
Jennifer R Brown Yang Feng John G Gribben Donna Neuberg David C Fisher Peter Mauch Lee M Nadler Arnold S Freedman 《Biology of blood and marrow transplantation》2007,13(9):1057-1065
The role of autologous stem cell transplantation (ASCT) in the treatment of follicular lymphoma is still being defined in the era of antibody therapy. Here we report the long-term 12-year clinical outcomes of patients treated with autologous bone marrow transplantation (ABMT) for follicular non-Hodgkin's lymphoma (NHL) in first remission. Between 1988 and 1993, advanced-stage follicular NHL patients in need of initial therapy were enrolled in 2 consecutive prospective treatment trials of either standard-dose CHOP induction (83 patients) or high-dose CHOP plus granulocyte-colony stimulating factor (G-CSF) (20 patients). Patients who achieved an adequate remission with induction therapy underwent conditioning with cyclophosphamide and total body irradiation (TBI) followed by ABMT in first remission using bone marrow (BM) purged in vitro with anti-B cell monoclonal antibodies and rabbit complement (96 patients). At 12-year follow-up, 61% of the patients are alive and 43% remain in continuing complete remission. The only predictors of decreased progression-free survival proved to be histologic BM involvement at time of harvest (hazard ratio [HR] 2.27, 95% confidence interval [CI] 1.3-3.9, P<.004) and PCR detectable disease in the BM product after purging (HR 4.18, 95% CI 1.99-8.8, P=.0002). No significant predictors of overall survival were identified. These results at 12-year follow-up suggest that a subset of follicular lymphoma patients can experience prolonged survival with ABMT in first remission. 相似文献
119.
THE ACTION OF RADIX REHMANNIAE AND
PLASTRUM TESTUDINIS ON BETA-
ADRENERGIC RECEPTOR-cAMP SYSTEM 总被引:1,自引:0,他引:1
Yi Ning-yu易宁育 Feng Guo-ping冯国平 Yu Yi-ming余逸明Lin Yu-zhong林育忠and Rong Zheng-xing荣征星Department of Pharmacology Shanghai Second Medical UniversityXia Zong-qin夏宗勤 Zhang Shi-de张世德 Hu Ya-er胡雅儿Isotopa Laboratory Shanghai Second Medical University Shanghai 《中华医学杂志(英文版)》1987,100(11):893-898
Mouse and rat pathological models were pro
duced by injections of thyroid hormone (T3 0r T4,
Model. I) or hydrocortisone (HC, Model II). A
single subcutaneous dose of isoproterenol (ISO)
caused plasma cAMP to peak in 5-15 min which
was significantly higher in mouse Models I and II
than in normal mice. Daily oral administration of
a decoction of two Yin tonics-Radix Rehmanniae
(RR) and Plastrum Testudinis (PT) reduced peak
cAMP in both models. 3H.DHA binding assay re
vealed significant elevations of the number of 3
adrenergic receptors in rat Models I and II. Decoc-
tion RR and PT restored the peaks to normal range.
Yang tonics Radix Aconiti praeparata (RAP) and
Cortex Cinnamomi (CC) showcd contradictory
effects on these models. It seems unlikely that the
action of the two tonics promotes the dlearance of
injected hormones, since injected hormone RIA iii
plasma showed no differences between Yin tonics
treated and untreated models. The therapeutic
effects of these two Yin tonics on "Yin deficiency"
syndrome of hyperthyroidism or hyperfunction of
the adrenal cortex is very probably related to their
actions on the O-adrenoreceptor-cAMP system as
stated. 相似文献
120.
作者用“点值法”对成都市内和郊区842例从事轻、中、重劳动的健康工人、农民和战士作了MEFV曲线和常规肺功能测定,发现工人和农民在低肺容积时流量增加,在高、中肺容积时流量下降,并以农民最明显,重劳动工人次之,轻、中劳动工人较不明显,战士则相反。揭示不同的体力活动方式及生活条件可导致不同肺容积时的流量改变,以适应其代谢增强时的耗氧需求。 相似文献